2. Gene
  3. Il1rap - interleukin 1 receptor accessory protein Gene

Il1rap - interleukin 1 receptor accessory protein Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: IL-1RAcP; 6430709H04Rik

基因 ID: 16180 | 基因类型: protein coding

关于 Il1rap

功能概要

Enables interleukin-1 receptor activity; interleukin-33 receptor activity; and protein tyrosine kinase binding activity. Involved in several processes, including interleukin-33-mediated signaling pathway; positive regulation of cytokine production; and regulation of synapse assembly. Acts upstream of or within cytokine-mediated signaling pathway; positive regulation of dendrite development; and positive regulation of synapse assembly. Located in glutamatergic synapse. Is expressed in dorsal aorta; future brain; genitourinary system; liver; and ventral grey horn. Orthologous to human IL1RAP (interleukin 1 receptor accessory protein). [provided by Alliance of Genome Resources, Apr 2022]

Il1rap 基因产物(4)

mRNA Protein Name
NM_001159317.1 NP_001152789.1 interleukin-1 receptor accessory protein isoform c precursor
NM_001159318.1 NP_001152790.1 interleukin-1 receptor accessory protein isoform d precursor
NM_008364.2 NP_032390.1 interleukin-1 receptor accessory protein isoform a precursor
NM_134103.2 NP_598864.1 interleukin-1 receptor accessory protein isoform b precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables interleukin-1 receptor activity IDA
IDA: 通过直接分析推断
11880380 MGI
enables interleukin-33 receptor activity IMP
IMP: 通过突变表型推断
17675517 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10854325 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cytokine-mediated signaling pathway IDA
IDA: 通过直接分析推断
11880380 MGI
acts upstream of or within interleukin-2 production IDA
IDA: 通过直接分析推断
11880380 MGI
involved in interleukin-33-mediated signaling pathway IMP
IMP: 通过突变表型推断
17675517 MGI
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
18003919 MGI
involved in positive regulation of interleukin-13 production IMP
IMP: 通过突变表型推断
17675517 MGI
involved in positive regulation of interleukin-4 production IMP
IMP: 通过突变表型推断
17675517 MGI
involved in positive regulation of interleukin-5 production IMP
IMP: 通过突变表型推断
17675517 MGI
involved in positive regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
18003919 MGI
involved in positive regulation of synapse assembly IDA
IDA: 通过直接分析推断
25908590 MGI
involved in regulation of postsynaptic density assembly IDA
IDA: 通过直接分析推断
22357843 MGI
involved in regulation of postsynaptic density assembly IMP
IMP: 通过突变表型推断
22357843 MGI
involved in regulation of presynapse assembly IDA
IDA: 通过直接分析推断
22357843 MGI
involved in regulation of presynapse assembly IMP
IMP: 通过突变表型推断
22357843 MGI
involved in synaptic membrane adhesion IDA
IDA: 通过直接分析推断
22357843 MGI
involved in synaptic membrane adhesion IMP
IMP: 通过突变表型推断
22357843 MGI
involved in trans-synaptic signaling by trans-synaptic complex IDA
IDA: 通过直接分析推断
22357843 MGI
involved in trans-synaptic signaling by trans-synaptic complex IMP
IMP: 通过突变表型推断
22357843 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
22357843 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
22357843 MGI
is active in synapse IDA
IDA: 通过直接分析推断
22357843 MGI
is active in synapse IMP
IMP: 通过突变表型推断
22357843 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

interleukin-1 receptor accessory protein

IL-1 receptor accessory protein

interleukin-33 receptot beta chain

Il1rap 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Il1rap Q61730 Il1rl1 Mus musculus P14719
Anti Tag CoIP
18003919
种属内
Il1rap Q61730 Tollip Mus musculus Q9QZ06
CoIP
10854325
种属内
Il1rap Q61730 Tollip Mus musculus Q9QZ06
Y2H
10854325
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 Il1rap 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77417 IL-1RAcP/IL-1 R3 Protein, Mouse (HEK293, Fc) Q61730-1 (S21-K350) ≥95%
HY-P78311 IL-1RAcP/IL-1 R3 Protein, Mouse (HEK293, His) Q61730-1 (S21-T367) ≥95%

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99379 Nidanilimab (Nadunolimab) Inhibitor 99.90% Phase 2
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06722 IL1RAP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Il1rap NCBI NCBI:3556
Macaca fascicularis Il1rap NCBI NCBI:102133222
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