2. Gene
  3. Itk - IL2 inducible T cell kinase Gene

Itk - IL2 inducible T cell kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：IL2 诱导型 T 细胞激酶

种属: Mus musculus

同用名: Emt; Tsk; Tcsk

基因 ID: 16428 | 基因类型: protein coding

关于 Itk

Chromosome 11: 46,215,977-46,280,342 reverse strand.GRCm39:CM001004.3

This gene has 4 transcripts (splice variants), 208 orthologues, 32 paralogues and is associated with 39 phenotypes. Biased expression in thymus adult (RPKM 35.8), spleen adult (RPKM 4.7) and 1 other tissue.

功能概要

预计该基因编码的蛋白可启动非跨膜蛋白酪氨酸激酶活性。参与多个过程，包括T细胞受体信号通路；激活磷脂酶 C 活性；和 γ-δ T 细胞活化。作用于 NK T 细胞分化的上游或内部。位于细胞间连接处和细胞核。该基因的人类直系同源物与淋巴增生综合征 1 相关。与人类 ITK（IL2 诱导型 T 细胞激酶）直系同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including T cell receptor signaling pathway; activation of Phospholipase C activity; and gamma-delta T cell activation. Acts upstream of or within NK T cell differentiation. Located in cell-cell junction and nucleus. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 1. Orthologous to human Itk (IL2 inducible T cell kinase). [provided by Alliance of Genome Resources, Apr 2022]

Itk 基因产物(5)

mRNA Protein Name
NM_010583.3 NP_034713.2 tyrosine-protein kinase ITK/TSK isoform 2
NM_001281965.1 NP_001268894.1 tyrosine-protein kinase ITK/TSK isoform 1
NM_001281968.1 NP_001268897.1 tyrosine-protein kinase ITK/TSK isoform 5
NM_001281966.1 NP_001268895.1 tyrosine-protein kinase ITK/TSK isoform 3
NM_001281967.1 NP_001268896.1 tyrosine-protein kinase ITK/TSK isoform 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15662016 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within NK T cell differentiation IGI
IGI: 通过遗传相互作用推断
18292523 MGI
acts upstream of or within NK T cell differentiation IMP
IMP: 通过突变表型推断
18292523 MGI
involved in T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
10213685 MGI
involved in adaptive immune response IMP
IMP: 通过突变表型推断
10213685 MGI
involved in gamma-delta T cell activation IMP
IMP: 通过突变表型推断
23562159 MGI
acts upstream of or within interleukin-4 production IGI
IGI: 通过遗传相互作用推断
18292523 MGI
acts upstream of or within interleukin-4 production IMP
IMP: 通过突变表型推断
18292523 MGI
involved in positive regulation of cytokine production IMP
IMP: 通过突变表型推断
10213685 MGI
involved in protein phosphorylation IMP
IMP: 通过突变表型推断
15662016 MGI
acts upstream of or within type II interferon production IGI
IGI: 通过遗传相互作用推断
18292523 MGI
acts upstream of or within type II interferon production IMP
IMP: 通过突变表型推断
18292523 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell-cell junction IDA
IDA: 通过直接分析推断
23793062 MGI
located in nucleus IDA
IDA: 通过直接分析推断
15662016 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Itk 蛋白结构

PH_Btk

PH_Btk: cd01238 (6 - 147)

SH3_ITK

SH3_ITK: cd11908 (173 - 228)

SH2_Tec_Itk

SH2_Tec_Itk: cd10396 (231 - 338)

PTKc_Itk

PTKc_Itk: cd05112 (356 - 611)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 619 a.a.
蛋白主名 其他名称

tyrosine-protein kinase ITK/TSK

T-cell-specific kinase

interleukin-2-inducible T cell kinase

kinase TLK

重组 Itk 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74795 ITK Protein, Mouse (sf9, His-GST) Q03526 (R351-L619) ≥95%

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-109078 Vecabrutinib Inhibitor 99.76% Phase 2
HY-150298 Soquelitinib Inhibitor 99.71% Phase 1
Pre-clinical Phase
生物活性分子 (16)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-11092 BMS-509744 Inhibitor 98.09% 否
HY-12680 PRN694 Inhibitor ≥99.0% 否
HY-108691 PF-06465469 Inhibitor 99.48% 否
HY-128726 ITK inhibitor 2 Inhibitor 99.66% 否
HY-150023 BI-1622 Inhibitor 98.97% 否
HY-12410 GNE-9822 Inhibitor ≥95.0% 否
HY-146672 ITK inhibitor 6 Inhibitor / 否
HY-146671 ITK inhibitor 5 Inhibitor / 否
HY-120559 GSK-2250665A Inhibitor / 否
HY-13232 ITK antagonist Inhibitor / 否
HY-101321A Immepip dihydrobromide Degrader 99.89% 否
HY-143901 EGFR-IN-40 Inhibitor / 否
HY-153322 ITK degrader 2 Degrader / 否
HY-141864 ITK/TRKA-IN-1 Inhibitor / 否
HY-149917 ITK degrader 1 Degrader / 否
HY-16984 GNE-4997 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Itk NCBI NCBI:3702
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