DDX1 - DEAD-box helicase 1 Gene

中文名称：死盒解旋酶 1

种属: Homo sapiens

同用名: DBP-RB; UKVH5d

基因 ID: 1653 | 基因类型: protein coding

关于 DDX1

Cytogenetic location: 2p24.3 Genomic coordinates (GRCh38): 2:15,591,868-15,631,101 (from NCBI)

This gene has 24 transcripts (splice variants), 198 orthologues and 38 paralogues. Ubiquitous expression in thyroid (RPKM 36.4), brain (RPKM 36.1) and 25 other tissues.

功能概要

以保守基序 Asp-Glu-Ala-Asp (DEAD) 为特征的 DEAD 盒蛋白是推定的 RNA 解旋酶。它们涉及许多涉及 RNA 二级结构改变的细胞过程，例如翻译起始、核和线粒体剪接以及核糖体和剪接体组装。根据它们的分布模式，该家族的一些成员被认为参与了胚胎发生、精子发生以及细胞生长和分裂。该基因编码一种 DEAD 盒蛋白，该蛋白充当 ATP 依赖性 RNA 解旋酶，已被发现可促进冠状病毒复制。[RefSeq 提供，2021 年 8 月]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that acts as an ATP-dependent RNA helicase that has been found to promote coronaviruses replication. [provided by RefSeq, Aug 2021]

DDX1 基因产物(1)

mRNA	Protein	Name
NM_004939.3	NP_004930.1	ATP-dependent RNA helicase DDX1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA/RNA helicase activity	IDA IDA: 通过直接分析推断	18710941	GOA
enables RNA helicase activity	IDA IDA: 通过直接分析推断	12183465	GOA
enables chromatin binding	IDA IDA: 通过直接分析推断	19058135	GOA
enables nuclease activity	IDA IDA: 通过直接分析推断	18710941	GOA
enables poly(A) binding	IDA IDA: 通过直接分析推断	12183465	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11598190	GOA
enables transcription coregulator activity	IDA IDA: 通过直接分析推断	19058135	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA duplex unwinding	IDA IDA: 通过直接分析推断	18710941	GOA
involved in double-strand break repair	IDA IDA: 通过直接分析推断	18710941	GOA
involved in nucleic acid metabolic process	IDA IDA: 通过直接分析推断	18710941	GOA
involved in protein localization to cytoplasmic stress granule	IMP IMP: 通过突变表型推断	24965446	GOA
involved in tRNA splicing, via endonucleolytic cleavage and ligation	IMP IMP: 通过突变表型推断	24870230	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cleavage body	IDA IDA: 通过直接分析推断	11598190	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	24608264	GOA
located in cytoplasmic stress granule	IDA IDA: 通过直接分析推断	18335541	GOA
located in nucleus	IDA IDA: 通过直接分析推断	19058135	GOA
part of ribonucleoprotein complex	IDA IDA: 通过直接分析推断	18809582	GOA
part of tRNA-splicing ligase complex	IDA IDA: 通过直接分析推断	21311021	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DDX1 蛋白结构

DEAD

SPRY

Helicase_C

0
200
400
600
740 a.a.

蛋白主名

其他名称

ATP-dependent RNA helicase DDX1

DEAD (Asp-Glu-Ala-Asp) box helicase 1

DDX1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DDX1	Q92499	RTRAF	Homo sapiens	Q9Y224	Anti Tag CoIP	33961781
种属内	DDX1	Q92499	RTRAF	Homo sapiens	Q9Y224	GMS	24608264
种属内	DDX1	Q92499	FAM98A	Homo sapiens	Q8NCA5	Anti Tag CoIP	33961781
种属内	DDX1	Q92499	FAM98A	Homo sapiens	Q8NCA5	Anti Tag CoIP	28040436
种属间	DDX1	Q92499	N	SARS-CoV-2	P0DTC9	Confocal	35107372

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Bronchitis

Chronic Bronchitis	Acute Bronchitis
Bronchitis, Chronic	Acute Bronchitis And Bronchiolitis
Chest Cold	Chest Infection
Ci - Chest Infection	Recurrent Wheezy Bronchitis
Bronchitis Chronic	Lower Respiratory Tract Infection
Acute Lower Respiratory Tract Infection	Chronic Bronchitis Nos
Senile Bronchitis	Bronchitis Nos In Those Under L5 Years Of Age
Bronchitis Nos

Small Cell Carcinoma

Small Cell Carcinoma, Intermediate Cell	Intermediate Cell Small Cell Carcinoma
Small Cell Carcinoma - Intermediate Cell	Small Cell Carcinoma Of Lung
Carcinoma, Small Cell

Venezuelan Equine Encephalitis

Venezuelan Equine Fever	Venezuelan Equine Encephalomyelitis
Encephalitis Venezuelan Equine	Encephalomyelitis, Venezuelan Equine
Venezuelan Encephalitis	Disorder Due To Venezuelan Equine Encephalitis Virus
Venezuelan Equine Encephalitis Virus Infection	Venezuelan Equine Encephalomyelitis Virus Disease

Encephalitis

Mumps Encephalitis	Mumps Meningoencephalitis
Herpes Simplex Neuroinvasion	Herpetic Encephalitis
Herpetic Encephalopathy	Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis
Encephalitis Due To Herpesviridae	Encephalitis Due To Herpesvirus
Herpes Encephalitis	Herpesviral Encephalitis
Herpes Simplex Encephalitis	Hsv - [Herpes Simplex Virus] Encephalitis
Herpes Virus Encephalitis	Simian B Disease
Simian B Disorder	Encephalitis Nec
Idiopathic Encephalitis

Heavy Chain Disease

Hcd

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Lacrimal Duct Obstruction

Blocked Lacrimal Canaliculus	Obstruction Of Lacrimal Canaliculus
Obstruction Of Lacrimal Ducts

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03629	DDX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	DDX1	RGD	RGD:619903
Macaca mulatta	DDX1	VGNC	VGNC:71759
Mus musculus	DDX1	MGD	MGI:2144727
Canis familiaris	DDX1	VGNC	VGNC:39844
Bos taurus	DDX1	VGNC	VGNC:27955
Felis catus	DDX1	VGNC	VGNC:61396
Others	DDX1	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DDX1 - DEAD-box helicase 1 Gene

关于 DDX1

功能概要

DDX1 基因产物(1)

DDX1 蛋白结构

DDX1 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

DDX1 - DEAD-box helicase 1 Gene

关于 DDX1

功能概要

DDX1 基因产物(1)

DDX1 蛋白结构

DDX1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z