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  2. RTRAF - RNA transcription, translation and transport factor Gene

RTRAF - RNA transcription, translation and transport factor Gene

中文名称:RNA 转录、翻译和转运因子

种属: Homo sapiens

同用名: CLE; CLE7; hCLE; CGI99; RLLM1; hCLE1; CGI-99; LCRP369; C14orf166

基因 ID: 51637 | 基因类型: protein coding

关于 RTRAF

Cytogenetic location: 14q22.1 Genomic coordinates (GRCh38): 14:51,989,546-52,010,694 (from NCBI)

This gene has 7 transcripts (splice variants) and 232 orthologues. Ubiquitous expression in testis (RPKM 109.7), fat (RPKM 62.2) and 25 other tissues.

功能概要

启用 RNA 结合活动; RNA 聚合酶 II 复合物结合活性;和相同的蛋白质结合活性。参与蛋白激酶活性的负调节; RNA 聚合酶 II 对转录的正调控;和 tRNA 剪接,通过核酸内切裂解和连接。位于微管细胞骨架;核质;和细胞质的核周区。 tRNA 剪接连接酶复合物的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Enables RNA binding activity; RNA polymerase II complex binding activity; and identical protein binding activity. Involved in negative regulation of protein kinase activity; positive regulation of transcription by RNA polymerase II; and tRNA splicing, via endonucleolytic cleavage and ligation. Located in microtubule cytoskeleton; nucleoplasm; and perinuclear region of cytoplasm. Part of tRNA-splicing Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

RTRAF 基因产物(1)

mRNA Protein Name
NM_016039.3 NP_057123.1 RNA transcription, translation and transport factor protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
24608264 GOA
enables RNA polymerase II complex binding IDA
IDA: 通过直接分析推断
16950395 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
15147888 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11507205 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of protein kinase activity IMP
IMP: 通过突变表型推断
15147888 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
16950395 GOA
involved in tRNA splicing, via endonucleolytic cleavage and ligation IMP
IMP: 通过突变表型推断
24870230 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
15147888 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
24608264 GOA
located in mitotic spindle IDA
IDA: 通过直接分析推断
15147888 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15147888 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
15147888 GOA
part of tRNA-splicing ligase complex IDA
IDA: 通过直接分析推断
21311021 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RTRAF 蛋白结构

RLL

RLL: Putative carnitine deficiency-associated protein (1 - 244)

  • 0
  • 100
  • 200
  • 244 a.a.
蛋白主名 其他名称

RNA transcription, translation and transport factor protein

CLE7 homolog

RTRAF 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RTRAF Q9Y224 FAM98B Homo sapiens Q52LJ0
TAP
24608264
种属内
RTRAF Q9Y224 FAM98B Homo sapiens Q52LJ0
Crosslink
30021884
种属内
RTRAF Q9Y224 FAM98A Homo sapiens Q8NCA5
Y2H Array
31515488
种属内
RTRAF Q9Y224 DDX1 Homo sapiens Q92499
Crosslink
30021884
种属内
RTRAF Q9Y224 FAM98A Homo sapiens Q8NCA5
TAP
24608264
种属内
RTRAF Q9Y224 RTRAF Homo sapiens Q9Y224
Y2H
15147888
种属内
RTRAF Q9Y224 FAM98A Homo sapiens Q8NCA5
Anti Tag CoIP
28040436
种属内
RTRAF Q9Y224 RTRAF Homo sapiens Q9Y224
GMS
24608264
种属内
RTRAF Q9Y224 DDX1 Homo sapiens Q92499
TAP
24608264
种属内
RTRAF Q9Y224 FAM98A Homo sapiens Q8NCA5
Y2H Array
25416956
种属内
RTRAF Q9Y224 RTCB Homo sapiens Q9Y3I0
Pull Down
30833792
种属内
RTRAF Q9Y224 RTRAF Homo sapiens Q9Y224
Pull Down
15147888
种属内
RTRAF Q9Y224 RTRAF Homo sapiens Q9Y224
Comig Non-Denat Gel
24608264
种属内
RTRAF Q9Y224 RTCB Homo sapiens Q9Y3I0
TAP
24608264
种属内
RTRAF Q9Y224 RTRAF Homo sapiens Q9Y224
Comigration in SDS
24608264
种属内
RTRAF Q9Y224 NIN Homo sapiens Q8N4C6
IF
15147888
种属内
RTRAF Q9Y224 NIN Homo sapiens Q8N4C6
Y2H
15147888
种属内
RTRAF Q9Y224 C2orf49 Homo sapiens Q9BVC5
Crosslink
30021884
种属间
RTRAF Q9Y224 PA Influenza A virus P31343
Pull Down
11507205
种属间
RTRAF Q9Y224 PA Influenza A virus P31343
Y2H
11507205
种属间
RTRAF Q9Y224 PA Influenza A virus Q67020
BiFC
21994455
种属间
RTRAF Q9Y224 PA Influenza A virus Q67020
Y2H
21994455
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified

Central Nervous System Germinoma

Germinoma Of The Central Nervous System

Intracranial Germinoma

Germinoma Of Cns

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta RTRAF VGNC VGNC:77087
Rattus norvegicus RTRAF RGD RGD:1304704
Mus musculus RTRAF MGD MGI:1915295
Felis catus RTRAF VGNC VGNC:103749
Bos taurus RTRAF VGNC VGNC:49536