2. Gene
  3. Arhgef2 - rho/rac guanine nucleotide exchange factor (GEF) 2 Gene

Arhgef2 - rho/rac guanine nucleotide exchange factor (GEF) 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: GEF; Lfc; P40; GEFH1; LFP40; Lbcl1; GEF-H1; mKIAA0651

基因 ID: 16800 | 基因类型: protein coding

关于 Arhgef2

功能概要

Enables guanyl-nucleotide exchange factor activity and microtubule binding activity. Involved in several processes, including establishment of mitotic spindle orientation; generation of neurons; and positive regulation of neuron migration. Acts upstream of or within several processes, including actin filament organization; negative regulation of podosome assembly; and regulation of Rho protein signal transduction. Located in several cellular components, including dendritic shaft; podosome; and postsynaptic density. Is expressed in several structures, including brain; dorsal root ganglion; and testis. Used to study neurodevelopmental disorder with midbrain and hindbrain malformations. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with midbrain and hindbrain malformations. Orthologous to human ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Arhgef2 基因产物(5)

mRNA Protein Name
NM_001198911.2 NP_001185840.1 rho guanine nucleotide exchange factor 2 isoform 2
NM_001198912.2 NP_001185841.1 rho guanine nucleotide exchange factor 2 isoform 3
NM_001198913.2 NP_001185842.1 rho guanine nucleotide exchange factor 2 isoform 4
NM_001377126.1 NP_001364055.1 rho guanine nucleotide exchange factor 2 isoform 5
NM_008487.4 NP_032513.3 rho guanine nucleotide exchange factor 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables guanyl-nucleotide exchange factor activity IDA
IDA: 通过直接分析推断
15996550 MGI
enables microtubule binding IDA
IDA: 通过直接分析推断
15996550 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15996550 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within actin filament organization IPI
IPI: 通过物理相互作用推断
15996550 MGI
involved in asymmetric neuroblast division IMP
IMP: 通过突变表型推断
28453519 MGI
acts upstream of or within cell morphogenesis IDA
IDA: 通过直接分析推断
15996550 MGI
involved in establishment of mitotic spindle orientation IMP
IMP: 通过突变表型推断
19448628 MGI
involved in negative regulation of neurogenesis IMP
IMP: 通过突变表型推断
19448628 MGI
acts upstream of or within negative regulation of podosome assembly IMP
IMP: 通过突变表型推断
21352810 MGI
involved in positive regulation of neuron differentiation IMP
IMP: 通过突变表型推断
28453519 MGI
involved in positive regulation of neuron migration IMP
IMP: 通过突变表型推断
28453519 MGI
acts upstream of or within regulation of Rho protein signal transduction IDA
IDA: 通过直接分析推断
15996550 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendritic shaft IDA
IDA: 通过直接分析推断
15996550 MGI
located in neuronal cell body IDA
IDA: 通过直接分析推断
15996550 MGI
located in podosome IDA
IDA: 通过直接分析推断
21352810 MGI
located in postsynaptic density IDA
IDA: 通过直接分析推断
17114649 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

rho guanine nucleotide exchange factor 2

LBC'S first cousin

guanine nucleotide exchange factor H1

lymphoid blast crisis-like 1

oncogene LFC

rhobin

Arhgef2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Arhgef2 Q60875 Ksr1 Mus musculus Q61097
Anti Tag CoIP
24525234
种属内
Arhgef2 Q60875 Ksr1 Mus musculus Q61097
Anti Bait CoIP
24525234
种属内
Arhgef2 Q60875 Ccdc88b Mus musculus Q4QRL3
IF
38200184
种属内
Arhgef2 Q60875 Ccdc88b Mus musculus Q4QRL3
Anti Bait CoIP
38200184
种属内
Arhgef2 Q60875 Ccdc88b Mus musculus Q4QRL3
Anti Tag CoIP
38200184
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00954 ARHGEF2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Arhgef2 NCBI NCBI:9181
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