2. Gene
  3. Ksr1 - kinase suppressor of ras 1 Gene

Ksr1 - kinase suppressor of ras 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: hb; Ksr; RSU2; mKSR1; B-KSR1; D11Bhm183e; D11Bhm184e

基因 ID: 16706 | 基因类型: protein coding

关于 Ksr1

功能概要

Enables several functions, including 14-3-3 protein binding activity; ATP binding activity; and HSP90 protein binding activity. Involved in intracellular signal transduction; regulation of MAP kinase activity; and regulation of cell population proliferation. Acts upstream of or within positive regulation of MAPK cascade. Predicted to be located in cell projection and plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to human KSR1 (kinase suppressor of Ras 1). [provided by Alliance of Genome Resources, Apr 2022]

Ksr1 基因产物(2)

mRNA Protein Name
NM_001348207.1 NP_001335136.1 kinase suppressor of Ras 1 isoform 2
NM_013571.3 NP_038599.1 kinase suppressor of Ras 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 14-3-3 protein binding IPI
IPI: 通过物理相互作用推断
10409742 MGI
enables ATP binding IMP
IMP: 通过突变表型推断
21441104 MGI
enables Hsp90 protein binding IPI
IPI: 通过物理相互作用推断
10409742 MGI
enables MAP-kinase scaffold activity IDA
IDA: 通过直接分析推断
19560418 MGI
enables MAP-kinase scaffold activity IMP
IMP: 通过突变表型推断
10409742 MGI
enables mitogen-activated protein kinase kinase binding IPI
IPI: 通过物理相互作用推断
10409742 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12941695 MGI
enables protein kinase activity IMP
IMP: 通过突变表型推断
21441104 MGI
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
21441104 MGI
enables protein-folding chaperone binding IPI
IPI: 通过物理相互作用推断
10409742 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Ras protein signal transduction IMP
IMP: 通过突变表型推断
21102438 MGI
involved in cAMP-mediated signaling IMP
IMP: 通过突变表型推断
21102438 MGI
acts upstream of or within positive regulation of MAPK cascade IDA
IDA: 通过直接分析推断
19560418 MGI
involved in positive regulation of MAPK cascade IMP
IMP: 通过突变表型推断
10409742 MGI
involved in regulation of MAP kinase activity IMP
IMP: 通过突变表型推断
12874031 MGI
involved in regulation of cell population proliferation IMP
IMP: 通过突变表型推断
12874031 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

kinase suppressor of Ras 1

protein Hb

Ksr1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Ksr1 Q61097 VRK2 Homo sapiens Q86Y07-1
Pull Down
22752157
种属间
Ksr1 Q61097 NME1 Homo sapiens P15531
Anti Tag CoIP
15684389
种属间
Ksr1 Q61097 NME1 Homo sapiens P15531
Anti Bait CoIP
15684389
种属内
Ksr1 Q61097 Arhgef2 Mus musculus Q60875
Anti Bait CoIP
24525234
种属内
Ksr1 Q61097 Arhgef2 Mus musculus Q60875
CoIP
24525234
种属内
Ksr1 Q61097 Arhgef2 Mus musculus Q60875
Anti Tag CoIP
24525234
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07475 KSR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ksr1 NCBI NCBI:8844
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