Pik3ca - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Gene

中文名称：磷脂酰肌醇 4 ,5-二磷酸 3-激酶，催化亚基 α

种属: Rattus norvegicus

关于 Pik3ca

功能概要

该基因编码的蛋白可启动 1-磷脂酰肌醇-3-激酶活性。参与多个过程，包括平滑肌细胞增殖的正调节；对地塞米松的反应；和对亮氨酸的反应。磷脂酰肌醇 3-激酶复合物的一部分。常染色体隐性多囊肾病的生物标志物。该基因的人类直系同源物与多种疾病有关，包括 CLOVES 综合征；考登综合症 5；乳腺癌（多发性）；皮肤佩吉特病;和胃肠系统癌症（多发性）。与人 PIK3CA（磷脂酰肌醇 4,5-二磷酸 3-激酶催化亚基 α）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including positive regulation of smooth muscle cell proliferation; response to dexamethasone; and response to leucine. Part of phosphatidylinositol 3-kinase complex. Biomarker of autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome 5; breast Cancer (multiple); cutaneous Paget's disease; and gastrointestinal system Cancer (multiple). Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]