Ep300 - E1A binding protein p300 Gene

中文名称：E1A 结合蛋白 p300

种属: Rattus norvegicus

关于 Ep300

功能概要

该基因编码的蛋白可启动多种功能，包括 DNA 结合活性； DNA结合转录因子结合活性；和 p53 结合活性。参与多个过程，包括细胞对有机环状化合物的反应；细胞分化的正调控；蛋白质代谢过程的调控。位于染色质；细胞质；和核。蛋白质-DNA 复合物的一部分。用于研究糖尿病视网膜病变和膜增生性肾小球肾炎。先天性膈疝的生物标志物；心脏疾病;肝细胞癌；高血压;和短暂性脑缺血。该基因的人类直系同源物与 Rubinstein-Taybi 综合征有关；结直肠癌；和充血性心力衰竭。与人 EP300（E1A 结合蛋白 p300）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including DNA binding activity; DNA-binding transcription factor binding activity; and p53 binding activity. Involved in several processes, including cellular response to organic cyclic compound; positive regulation of cell differentiation; and regulation of protein metabolic process. Located in chromatin; cytoplasm; and nucleus. Part of protein-DNA complex. Used to study diabetic retinopathy and membranoproliferative glomerulonephritis. Biomarker of congenital diaphragmatic hernia; heart disease; hepatocellular carcinoma; hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; and congestive heart failure. Orthologous to human EP300 (E1A binding protein p300). [provided by Alliance of Genome Resources, Apr 2022]