1. Gene
  2. Map4k3 - mitogen-activated protein kinase kinase kinase kinase 3 Gene

Map4k3 - mitogen-activated protein kinase kinase kinase kinase 3 Gene

中文名称:丝裂原活化蛋白激酶激酶激酶激酶 3

种属: Rattus norvegicus

基因 ID: 170920 | 基因类型: protein coding

关于 Map4k3

Primary_assembly 6: 14,277,121-14,446,334 forward strand.mRatBN7.2:CM026979.1

This gene has 6 transcripts (splice variants), 211 orthologues, 36 paralogues and is associated with 4 phenotypes. Biased expression in Kidney (RPKM 225.), Lung (RPKM 194.) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 SH3 域绑定活动。预计参与多个过程,包括蛋白质磷酸化;对紫外线的反应;和对肿瘤坏死因子的反应。与人 MAP4K3(丝裂原活化蛋白激酶激酶 kinase kinase 3)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables SH3 domain binding activity. Predicted to be involved in several processes, including protein phosphorylation; response to UV; and response to tumor necrosis factor. Orthologous to human MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Map4k3 基因产物(1)

mRNA Protein Name
NM_133407.1 NP_596898.1 mitogen-activated protein kinase kinase kinase kinase 3
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SH3 domain binding IPI
IPI: 通过物理相互作用推断
11384986 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Map4k3 蛋白结构

STKc_MAP4K3_like

STKc_MAP4K3_like: cd06613 (14 - 272)

CNH

CNH: smart00036 (582 - 925)

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  • 946 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase kinase kinase kinase 3

GLK

MAPK/ERK kinase kinase kinase 3

MEK kinase kinase 3

MEKKK 3

germinal center kinase-related protein kinase

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Map4k3 NCBI NCBI:8491