2. Gene
  3. SHANK2 - Shank2 SH3 and multiple ankyrin repeat domains 2 Gene

SHANK2 - Shank2 SH3 and multiple ankyrin repeat domains 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: CortBP1; ProSAP1; Spank-3

基因 ID: 171093 | 基因类型: protein coding

关于 SHANK2

功能概要

Enables SH3 domain binding activity and protein C-terminus binding activity. A structural constituent of postsynaptic density. Involved in several processes, including adult locomotory behavior; associative learning; and social behavior. Located in several cellular components, including apical plasma membrane; cell projection membrane; and growth cone. Is active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human SHANK2 (SH3 and multiple ankyrin repeat domains 2). [provided by Alliance of Genome Resources, Apr 2022]

SHANK2 基因产物(4)

mRNA Protein Name
NM_001004133.1 NP_001004133.1 SH3 and multiple ankyrin repeat domains protein 2 isoform b
NM_133440.1 NP_597684.1 SH3 and multiple ankyrin repeat domains protein 2 isoform c
NM_133441.2 NP_597685.1 SH3 and multiple ankyrin repeat domains protein 2 isoform d
NM_201350.1 NP_958738.1 SH3 and multiple ankyrin repeat domains protein 2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SH3 domain binding IPI
IPI: 通过物理相互作用推断
15014124 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10958799 RGD
enables structural constituent of postsynaptic density IDA
IDA: 通过直接分析推断
21217644 RGD
enables structural constituent of postsynaptic density IMP
IMP: 通过突变表型推断
21217644 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adult locomotory behavior IMP
IMP: 通过突变表型推断
29970986 RGD
involved in associative learning IMP
IMP: 通过突变表型推断
29970986 RGD
involved in regulation of postsynapse organization IDA
IDA: 通过直接分析推断
21217644 RGD
involved in regulation of postsynapse organization IMP
IMP: 通过突变表型推断
21217644 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
15917299 RGD
involved in response to xenobiotic stimulus IMP
IMP: 通过突变表型推断
29970986 RGD
involved in social behavior IMP
IMP: 通过突变表型推断
29970986 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
17244609 RGD
is active in asymmetric synapse IDA
IDA: 通过直接分析推断
10414979 RGD
located in brush border membrane IDA
IDA: 通过直接分析推断
15917299 RGD
located in ciliary membrane IDA
IDA: 通过直接分析推断
18596612 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
10414979 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
21217644 RGD
located in growth cone IDA
IDA: 通过直接分析推断
10958799 RGD
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: 通过直接分析推断
10414979 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
10958799 RGD
is active in postsynaptic density IDA
IDA: 通过直接分析推断
10414979 RGD
located in presynaptic active zone IDA
IDA: 通过直接分析推断
21119615 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

SH3 and multiple ankyrin repeat domains protein 2

GKAP/SAPAP-interacting protein

SH3 and multiple ankyrin repeat domains protein 2-like

SH3/ankyrin domain gene 2

cortactin-binding protein 1

proline-rich synapse-associated protein 1

SHANK2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Cross Shank2 Q9QX74 CFTR Homo sapiens P13569
Y2H
14679199
Cross Shank2 Q9QX74 CFTR Homo sapiens P13569
SPR
17244609
Intra Shank2 Q9QX74 Plcb3 Rattus norvegicus Q99JE6
Y2H
15632121
Intra Shank2 Q9QX74 Plcb3 Rattus norvegicus Q99JE6
Anti Bait CoIP
15632121
Cross Shank2 Q9QX74 Arhgef7 Mus musculus Q9ES28-2
Anti Tag CoIP
12626503
Intra Shank2 Q9QX74 Pde4d Rattus norvegicus P14270-8
Anti Bait CoIP
17244609
Intra Shank2 Q9QX74 Pde4d Rattus norvegicus P14270-8
Pull Down
17244609
Intra Shank2 Q9QX74 Slc9a3 Rattus norvegicus P26433
Anti Bait CoIP
20080968
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12851 SHANK2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens SHANK2 NCBI NCBI:22941
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