Met - met proto-oncogene Gene

中文名称：遇见 原癌基因

种属: Mus musculus

同用名: HGF; HGFR; Par4; c-Met

关于 Met

功能概要

该基因编码的蛋白可启动肝细胞生长因子激活受体活性。参与细胞表面受体信号通路；化学突触传递的调节；和阳性趋化性。作用于多个过程的上游或内部，包括动物器官发育；调节细胞对压力的反应；和调节细胞因子的产生。位于膜内。以多种结构表达，包括消化系统；鳃弓;中枢神经系统;泌尿生殖系统；和肢体。用于研究 Gilles de la Tourette 综合症；自闭症谱系障碍；乳腺癌;和妊娠糖尿病。该基因的人类直系同源物与自闭症有关；常染色体隐性非综合征性耳聋 97；癌（多发性）；和多发性骨髓瘤。与人类 MET 同源（MET 原癌基因，受体酪氨酸激酶）。 [由基因组资源联盟提供，2022 年 4 月]

Enables hepatocyte growth factor-activated receptor activity. Involved in cell surface receptor signaling pathway; modulation of chemical synaptic transmission; and positive chemotaxis. Acts upstream of or within several processes, including animal organ development; regulation of cellular response to stress; and regulation of cytokine production. Located in membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and limb. Used to study Gilles de la Tourette syndrome; autism spectrum disorder; breast cancer; and gestational diabetes. Human ortholog(s) of this gene implicated in autistic disorder; autosomal recessive nonsyndromic deafness 97; carcinoma (multiple); and multiple myeloma. Orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]