2. Gene
  3. Met - MET proto-oncogene, receptor tyrosine kinase Gene

Met - MET proto-oncogene, receptor tyrosine kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：MET 原癌基因， 受体酪氨酸激酶

种属: Rattus norvegicus

同用名: Hgfr

基因 ID: 24553 | 基因类型: protein coding

关于 Met

Primary_assembly 4: 45,790,791-45,897,876 forward strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 207 orthologues, 54 paralogues and is associated with 88 phenotypes. Biased expression in Kidney (RPKM 289.7), Liver (RPKM 253.1) and 8 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括 β-连环蛋白结合活性；肝细胞生长因子激活受体活性；和磷脂酶结合活性。参与多个过程，包括动物器官发育；神经系统发育；和大分子代谢过程的正向调控。位于多个细胞成分中，包括突触后密度；突触后膜；和精子鞭毛。多种疾病的生物标志物，包括急性肾功能衰竭；肝胆系统癌（多发性）；肝脏良性肿瘤;胰腺炎;和牙周炎。该基因的人类直系同源物与自闭症有关；常染色体隐性非综合征性耳聋 97；癌（多发性）；和多发性骨髓瘤。与人类 MET 同源（MET 原癌基因，受体酪氨酸激酶）。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including beta-catenin binding activity; hepatocyte growth factor-activated receptor activity; and Phospholipase binding activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of macromolecule metabolic process. Located in several cellular components, including postsynaptic density; postsynaptic membrane; and sperm flagellum. Biomarker of several diseases, including acute kidney failure; hepatobiliary system Cancer (multiple); liver benign neoplasm; pancreatitis; and periodontitis. Human ortholog(s) of this gene implicated in autistic disorder; autosomal recessive nonsyndromic deafness 97; carcinoma (multiple); and multiple myeloma. Orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Met 基因产物(1)

mRNA Protein Name
NM_031517.2 NP_113705.1 hepatocyte growth factor receptor precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables beta-catenin binding IPI
IPI: 通过物理相互作用推断
16952352 RGD
enables hepatocyte growth factor receptor activity IMP
IMP: 通过突变表型推断
18262389 RGD
enables phosphatidylinositol 3-kinase binding IDA
IDA: 通过直接分析推断
7499789 RGD
enables phospholipase binding IPI
IPI: 通过物理相互作用推断
7499789 RGD
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
7499789 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
8833090 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to arsenic-containing substance IEP
IEP: 通过表达模式推断
16876216 RGD
involved in cellular response to glucose stimulus IEP
IEP: 通过表达模式推断
17124385 RGD
involved in cellular response to growth factor stimulus IEP
IEP: 通过表达模式推断
7526865 RGD
involved in cellular response to interleukin-6 IEP
IEP: 通过表达模式推断
8853431 RGD
involved in cellular response to peptide hormone stimulus IEP
IEP: 通过表达模式推断
17035232 RGD
involved in central nervous system neuron differentiation IEP
IEP: 通过表达模式推断
18262389 RGD
involved in flagellated sperm motility IMP
IMP: 通过突变表型推断
12399538 RGD
involved in lactation IEP
IEP: 通过表达模式推断
7628535 RGD
involved in liver development IEP
IEP: 通过表达模式推断
8506951 RGD
involved in male gonad development IEP
IEP: 通过表达模式推断
11316747 RGD
involved in negative regulation of peptidyl-threonine phosphorylation IMP
IMP: 通过突变表型推断
18262389 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
17427161 RGD
involved in neuron migration IDA
IDA: 通过直接分析推断
12106690 RGD
involved in neuron migration IMP
IMP: 通过突变表型推断
12106690 RGD
involved in oligodendrocyte development IEP
IEP: 通过表达模式推断
17382307 RGD
involved in pancreas development IEP
IEP: 通过表达模式推断
8954115 RGD
involved in positive regulation of DNA replication IMP
IMP: 通过突变表型推断
17427161 RGD
involved in positive regulation of dendrite morphogenesis IMP
IMP: 通过突变表型推断
18262389 RGD
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
18262389 RGD
involved in positive regulation of mitotic nuclear division IMP
IMP: 通过突变表型推断
17427161 RGD
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
18262389 RGD
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
18262389 RGD
involved in positive regulation of peptidyl-threonine phosphorylation IMP
IMP: 通过突变表型推断
18262389 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
17427161 RGD
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
7499789 RGD
involved in response to acidic pH IEP
IEP: 通过表达模式推断
7729276 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
19638569 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
17412609 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
18652820 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendrite IDA
IDA: 通过直接分析推断
17230549 RGD
located in excitatory synapse IDA
IDA: 通过直接分析推断
16861928 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
19794968 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
16861928 RGD
located in postsynaptic membrane IDA
IDA: 通过直接分析推断
16861928 RGD
located in sperm flagellum IDA
IDA: 通过直接分析推断
12399538 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Met 蛋白结构

Sema

Sema: cl15693 (24 - 516)

PSI

PSI: smart00423 (519 - 561)

IPT_plexin_repeat1

IPT_plexin_repeat1: cd01180 (563 - 656)

IPT_plexin_repeat2

IPT_plexin_repeat2: cd01179 (657 - 738)

IPT

IPT: cl15674 (742 - 837)

IPT

IPT: smart00429 (838 - 902)

PTKc_Met_Ron

PTKc_Met_Ron: cd05058 (1082 - 1343)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1382 a.a.
蛋白主名 其他名称

hepatocyte growth factor receptor

HGF receptor

HGF/SF receptor

SF receptor

c-Met

met proto-oncogene tyrosine kinase

proto-oncogene c-Met

scatter factor receptor

tyrosine-protein kinase Met

重组 Met 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72942 HGFR Protein, Rat (HEK293, Fc) Q2IBC7 (E25-N932) ≥95%

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-13016 Cabozantinib Inhibitor 99.96% 是
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-12035 AMG-208 Inhibitor 99.86% Phase 2
HY-16446 SAR125844 Inhibitor 98.17% Phase 2
HY-50683 JNJ-38877605 Inhibitor 99.95% Phase 1
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99455 Bafisontamab Inhibitor 96.00% Phase 3
Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-114357A DS-1205b free base Inhibitor 99.92% 否
HY-149675 VEGFR-2/c-Met-IN-2 Inhibitor / 否
HY-157387 c-Met-IN-22 Inhibitor / 否
HY-120908 c-Met-IN-16 Inhibitor / 否
HY-162803 c-Met-IN-24 Inhibitor / 否
HY-161372 PARP1/c-Met-IN-1 Inhibitor / 否
HY-123237 KRC-108 Inhibitor / 否
HY-168135 PROTAC c-Met degrader-1 Degrader / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Met NCBI NCBI:4233
Canis familiaris Met NCBI NCBI:403438
Macaca fascicularis Met NCBI NCBI:102123512
Mus musculus Met NCBI NCBI:17295
Susscrofa domestica Met NCBI
Macaca mulatta Met NCBI NCBI:704562
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