2. Gene
  3. Mif - macrophage migration inhibitory factor (glycosylation-inhibiting factor) Gene

Mif - macrophage migration inhibitory factor (glycosylation-inhibiting factor) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: GIF; DER6; Glif

基因 ID: 17319 | 基因类型: protein coding

关于 Mif

功能概要

Enables cytokine activity; phenylpyruvate tautomerase activity; and protease binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within DNA damage response, signal transduction by p53 class mediator; cell aging; and regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor). [provided by Alliance of Genome Resources, Apr 2022]

Mif 基因产物(1)

mRNA Protein Name
NM_010798.3 NP_034928.1 macrophage migration inhibitory factor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cytokine activity IDA
IDA: 通过直接分析推断
10364264 MGI
enables phenylpyruvate tautomerase activity IMP
IMP: 通过突变表型推断
16285950 MGI
enables protease binding IPI
IPI: 通过物理相互作用推断
21817065 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA damage response, signal transduction by p53 class mediator IMP
IMP: 通过突变表型推断
12878730 MGI
acts upstream of or within cellular senescence IMP
IMP: 通过突变表型推断
12878730 MGI
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
IDA: 通过直接分析推断
17045821 MGI
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
17045821 MGI
involved in negative regulation of mature B cell apoptotic process IDA
IDA: 通过直接分析推断
18056708 MGI
involved in negative regulation of myeloid cell apoptotic process IMP
IMP: 通过突变表型推断
11756671 MGI
involved in negative regulation of protein metabolic process IDA
IDA: 通过直接分析推断
11756671 MGI
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
10364264 MGI
involved in positive regulation of MAP kinase activity IDA
IDA: 通过直接分析推断
10364264 MGI
involved in positive regulation of arachidonate secretion IDA
IDA: 通过直接分析推断
10364264 MGI
involved in positive regulation of chemokine (C-X-C motif) ligand 2 production IDA
IDA: 通过直接分析推断
18056708 MGI
involved in positive regulation of fibroblast proliferation IDA
IDA: 通过直接分析推断
10364264 MGI
involved in positive regulation of lipopolysaccharide-mediated signaling pathway IMP
IMP: 通过突变表型推断
11756671 MGI
involved in positive regulation of myeloid leukocyte cytokine production involved in immune response IMP
IMP: 通过突变表型推断
11756671 MGI
involved in positive regulation of prostaglandin secretion involved in immune response IMP
IMP: 通过突变表型推断
11756671 MGI
involved in positive regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
10364264 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: 通过突变表型推断
12878730 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
11756671 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

macrophage migration inhibitory factor

L-dopachrome isomerase

L-dopachrome tautomerase

delayed early response protein 6

phenylpyruvate tautomerase

重组 Mif 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7388 MIF Protein, Mouse P34884 (M1-A115) ≥95%
HY-P70341 MIF Protein, Mouse (His) P34884 (P2-A115) ≥95%
HY-P70341AF Animal-Free MIF Protein, Mouse (His) P34884 (M1-A115) ≥95%
HY-P700517 MIF Protein, Mouse (P. pastoris, His) P34884 (P2-A115) ≥95%

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-17009 Iguratimod Inhibitor 99.93% 是
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-16692 ISO-1 Inhibitor 99.94% Phase 1
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99262 Imalumab Inhibitor 98.37% Phase 2
Pre-clinical Phase
生物活性分子 (30)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-110063 4-IPP Inhibitor 99.46% 否
HY-147390 MIF098 Inhibitor 99.88% 否
HY-110095 (±)-CPSI-1306 Antagonist 98.90% 否
HY-105077A Nemifitide diTFA 98.01% 否
HY-115887 R110 Inhibitor 99.90% 否
HY-123814 4-CPPC Inhibitor 99.64% 否
HY-107663A MIF-1 TFA Modulator 99.25% 否
HY-110084 BTZO-1 99.69% 否
HY-B0031S1 Quetiapine-d4 hemifumarate 99.69% 否
HY-N10096 Epoxyazadiradione 99.21% 否
HY-W164560 RDR 03785 Inhibitor 96.24% 否
HY-W019710 (E,E)-RGFP966 Inhibitor 99.31% 否
HY-130332 Mitomycin A Inhibitor 97.3% 否
HY-148117 MD13 Inhibitor / 否
HY-D0039 3-Cyanoumbelliferone ≥98.0% 否
HY-149308 MKA031 Inhibitor / 否
HY-107663 MIF-1 Modulator / 否
HY-115888 MIF2-IN-1 Inhibitor / 否
HY-144190 MIF-IN-1 Inhibitor / 否
HY-144194 MIF-IN-2 Inhibitor / 否
HY-144195 MIF-IN-3 Inhibitor / 否
HY-144196 MIF-IN-4 hydrochloride Inhibitor / 否
HY-146318 MIF-IN-5 Inhibitor / 否
HY-146319 MIF-IN-6 Inhibitor / 否
HY-155466 Boc-MIF-1-Am Activator / 否
HY-B0031S3 Quetiapine-d8 hemifumarate / 否
HY-B0076S Bisoprolol-d7 hemifumarate Inhibitor / 否
HY-P3087 Tyr-W-MIF-1 Modulator / 否
HY-RS08445 MIF Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-U00271 Pareptide monohydrochloride / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mif NCBI NCBI:4282
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