Nfkb2 - nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 Gene

中文名称：细胞 2 中 κ轻多肽基因增强子的核因子，p49 /p100

种属: Mus musculus

同用名: lyt; p49; p52; p50B; p49/p100; NF-kappaB2

关于 Nfkb2

功能概要

预测该基因编码的蛋白可实现 DNA 结合转录激活因子活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。作用于多个过程的上游或内部，包括 NIK/NF-kappaB 信号；滤泡树突状细胞分化；和生发中心的形成。位于核内。以多种结构表达，包括早期孕体；泌尿生殖系统；肌肉组织；胸腺原基；和三叉神经节。用于研究常见的变异型免疫缺陷。该基因的人类直系同源物与常见的可变免疫缺陷有关。与人类 NFKB2（核因子 kappa B 亚基 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including NIK/NF-kappaB signaling; follicular dendritic cell differentiation; and germinal center formation. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; musculature; thymus primordium; and trigeminal ganglion. Used to study common variable immunodeficiency. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human NFKB2 (nuclear factor kappa B subunit 2). [provided by Alliance of Genome Resources, Apr 2022]