2. Gene
  3. Pikfyve - phosphoinositide kinase, FYVE type zinc finger containing Gene

Pikfyve - phosphoinositide kinase, FYVE type zinc finger containing Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：磷酸肌醇激酶，含 FYVE 型锌指

种属: Mus musculus

同用名: p235; Pip5k; Pip5k3; Pipk5k3; PipkIII; 5230400C17Rik

基因 ID: 18711 | 基因类型: protein coding

关于 Pikfyve

Chromosome 1: 65,225,842-65,317,854 forward strand.GRCm39:CM000994.3

This gene has 11 transcripts (splice variants), 205 orthologues, 13 paralogues and is associated with 46 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 3.4), CNS E18 (RPKM 3.3) and 28 other tissues.

功能概要

该基因编码的蛋白可启动磷酸转移酶活性、醇基作为受体和锌离子结合活性。参与多个过程，包括中性粒细胞趋化性；磷脂酰肌醇代谢过程；和囊泡组织。作用于髓磷脂组装的上游或内部。位于多个细胞成分中，包括细胞-细胞连接；细胞质的核周区；和囊泡膜。在大脑中表达；泌尿生殖系统；外皮系统；肢;和骨架。用于研究克罗恩病。该基因的人类直系同源物与 Fleck 角膜营养不良有关。与人 PIKfyve 同源（磷酸肌醇激酶，含有 FYVE 型锌指）。 [由基因组资源联盟提供，2022 年 4 月]

Enables phosphotransferase activity, alcohol group as acceptor and zinc ion binding activity. Involved in several processes, including neutrophil chemotaxis; phosphatidylinositol metabolic process; and vesicle organization. Acts upstream of or within myelin assembly. Located in several cellular components, including cell-cell junction; perinuclear region of cytoplasm; and vesicle membrane. Is expressed in brain; genitourinary system; integumental system; limb; and skeleton. Used to study Crohn's disease. Human ortholog(s) of this gene implicated in Fleck corneal dystrophy. Orthologous to human PIKfyve (phosphoinositide kinase, FYVE-type zinc finger containing). [provided by Alliance of Genome Resources, Apr 2022]

Pikfyve 基因产物(2)

mRNA Protein Name
NM_001310624.1 NP_001297553.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform 1
NM_011086.2 NP_035216.2 1-phosphatidylinositol 3-phosphate 5-kinase isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity IDA
IDA: 通过直接分析推断
10419465 MGI
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA
IDA: 通过直接分析推断
9858586 MGI
enables 1-phosphatidylinositol-5-kinase activity IDA
IDA: 通过直接分析推断
10419465 MGI
enables kinase activity IDA
IDA: 通过直接分析推断
14530284 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
14530284 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
11123925 MGI
enables zinc ion binding IDA
IDA: 通过直接分析推断
9858586 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process IDA
IDA: 通过直接分析推断
11123925 MGI
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
9858586 MGI
involved in melanosome organization IMP
IMP: 通过突变表型推断
29584722 MGI
acts upstream of or within myelin assembly IGI
IGI: 通过遗传相互作用推断
22028665 MGI
involved in neutrophil chemotaxis IDA
IDA: 通过直接分析推断
28779020 MGI
NOT involved in neutrophil degranulation IDA
IDA: 通过直接分析推断
28779020 MGI
involved in peptidyl-serine autophosphorylation IDA
IDA: 通过直接分析推断
11123925 MGI
involved in phagosome maturation IDA
IDA: 通过直接分析推断
27623384 MGI
involved in phagosome-lysosome fusion IDA
IDA: 通过直接分析推断
28779020 MGI
involved in phosphatidylinositol 5-phosphate metabolic process IDA
IDA: 通过直接分析推断
11123925 MGI
involved in protein targeting to membrane IDA
IDA: 通过直接分析推断
14530284 MGI
involved in regulation of reactive oxygen species biosynthetic process IDA
IDA: 通过直接分析推断
28779020 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell-cell junction IDA
IDA: 通过直接分析推断
23793062 MGI
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
11112776 MGI
located in cytosol IDA
IDA: 通过直接分析推断
11112776 MGI
NOT located in insulin-responsive compartment IDA
IDA: 通过直接分析推断
11112776 MGI
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
19056739 MGI
located in vesicle membrane IDA
IDA: 通过直接分析推断
9858586 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pikfyve 蛋白结构

FYVE_PIKfyve_Fab1

FYVE_PIKfyve_Fab1: cd15725 (153 - 214)

DEP_PIKfyve

DEP_PIKfyve: cd04448 (356 - 437)

Fab1_TCP

Fab1_TCP: cd03334 (616 - 876)

PIPKc_PIKfyve

PIPKc_PIKfyve: cd17300 (1816 - 2082)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2097 a.a.
蛋白主名 其他名称

1-phosphatidylinositol 3-phosphate 5-kinase

FYVE finger-containing phosphoinositide kinase

PIPkin-III

PtdIns(4)P-5-kinase

phosphatidylinositol 3-phosphate 5-kinase type III

phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III

phosphatidylinositol-4-phosphate 5-kinase, type III

phosphoinositide kinase, FYVE finger containing

serine-protein kinase PIKFYVE

type III PIP kinase

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-14644 Apilimod Inhibitor 99.80% Phase 2
HY-14644A Apilimod mesylate Inhibitor 99.83% Phase 2
Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13228 YM-201636 Inhibitor 98.05% 否
HY-118630 Vacuolin-1 Inhibitor 98.93% 否
HY-15982 APY0201 Inhibitor 99.93% 否
HY-119624 MOMIPP Inhibitor 99.37% 否
HY-155994 PIK5-12d Degrader 99.90% 否
HY-151473 PIKfyve-IN-1 Inhibitor 99.64% 否
HY-160477 DC-SX029 Inhibitor 98.07% 否
HY-163133 PIKfyve-IN-3 99.55% 否
HY-161619 RMC-113 Inhibitor 99.54% 否
HY-154956 PIKfyve-IN-2 Inhibitor ≥98.0% 否
HY-163943 UNI418 Inhibitor / 否
HY-159625 WX8 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pikfyve NCBI NCBI:200576
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