2. Gene
  3. Pim1 - proviral integration site 1 Gene

Pim1 - proviral integration site 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：原病毒整合位点 1

种属: Mus musculus

同用名: Pim-1

基因 ID: 18712 | 基因类型: protein coding

关于 Pim1

Chromosome 17: 29,709,727-29,715,086 forward strand.GRCm39:CM001010.3

This gene has 7 transcripts (splice variants), 245 orthologues, 2 paralogues and is associated with 5 phenotypes. Broad expression in adrenal adult (RPKM 59.9), duodenum adult (RPKM 47.) and 24 other tissues.

功能概要

该基因编码的蛋白可启动 ATP 绑定活动；锰离子结合活性；和蛋白丝氨酸/苏氨酸激酶活性。参与多个过程，包括棕色脂肪细胞分化的正调节；蛋白质稳定性；和造血干细胞增殖的调节。预测位于胞质溶胶中；核仁;和质膜。预计在细胞质中有活性。以多种结构表达，包括性腺；原条;和脾脏。与人 PIM1 同源（Pim-1 原癌基因，丝氨酸/苏氨酸激酶）。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP binding activity; manganese ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of brown fat cell differentiation; protein stabilization; and regulation of hematopoietic stem cell proliferation. Predicted to be located in cytosol; nucleolus; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including gonad; primitive streak; and spleen. Orthologous to human PIM1 (Pim-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Pim1 基因产物(2)

mRNA Protein Name
NM_008842.4 NP_032868.2 serine/threonine-protein kinase pim-1 isoform 1
NM_001364913.1 NP_001351842.1 serine/threonine-protein kinase pim-1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
1825810 MGI
enables manganese ion binding IDA
IDA: 通过直接分析推断
1825810 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
18438430 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
1825810 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
18438430 MGI
involved in positive regulation of brown fat cell differentiation IMP
IMP: 通过突变表型推断
27923061 MGI
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
1825810 MGI
involved in protein stabilization IDA
IDA: 通过直接分析推断
18438430 MGI
involved in regulation of hematopoietic stem cell proliferation IDA
IDA: 通过直接分析推断
23495171 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pim1 蛋白结构

PKc_like

PKc_like: cl21453 (36 - 289)

  • 0
  • 100
  • 200
  • 313 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase pim-1

proto-oncogene serine/threonine-protein kinase pim-1

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-101870B Uzansertib phosphate Inhibitor 99.39% Phase 2
HY-19322B PIM-447 dihydrochloride Inhibitor 99.94% Phase 1
Pre-clinical Phase
生物活性分子 (29)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10371 Pim1/AKK1-IN-1 Inhibitor 98.20% 否
HY-N4149 Quercetagetin Inhibitor 99.94% 否
HY-16576A SMI-4a Inhibitor 99.63% 否
HY-16976 GDC-0339 Inhibitor 99.87% 否
HY-101947 SMI-16a Inhibitor ≥98.0% 否
HY-135906 CK2/ERK8-IN-1 Inhibitor ≥99.0% 否
HY-120758 SEL24-B489 Inhibitor 99.02% 否
HY-18086 TCS PIM-1 1 Inhibitor 98.01% 否
HY-111552 PIM1-IN-1 Inhibitor 99.83% 否
HY-122665 HTH-01-091 Inhibitor 98.64% 否
HY-108605 PIM1-IN-2 Inhibitor ≥99.0% 否
HY-164460 AZD1897 Inhibitor / 否
HY-101870 Uzansertib Inhibitor / 否
HY-149054 GSK-3β inhibitor 13 Inhibitor / 否
HY-168517 PIM-1/CK2-IN-2 Inhibitor / 否
HY-168071 Pim-1 kinase inhibitor 11 Inhibitor / 否
HY-135816 CK2/PIM1-IN-1 Inhibitor / 否
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / 否
HY-163119 Pim-1 kinase inhibitor 9 Inhibitor / 否
HY-143897 PIM1-IN-3 Inhibitor / 否
HY-156470 Multi-kinase-IN-6 Inhibitor / 否
HY-147921 PIM1-IN-7 Inhibitor / 否
HY-150731 Pim-1 kinase inhibitor 3 Inhibitor / 否
HY-147920 PIM1-IN-6 Inhibitor / 否
HY-142696 CDK6/PIM1-IN-1 Inhibitor / 否
HY-123983 HS56 Inhibitor / 否
HY-143898 PIM1-IN-4 Inhibitor / 否
HY-157404 Pim-1/2 kinase inhibitor 2 Inhibitor / 否
HY-101783 GNE-955 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pim1 NCBI NCBI:5292
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z