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  2. Mapk11 - mitogen-activated protein kinase 11 Gene

Mapk11 - mitogen-activated protein kinase 11 Gene

中文名称:丝裂原活化蛋白激酶 11

种属: Mus musculus

同用名: P38b; Sapk2; p38-2; Prkm11; Sapk2b; p38beta; p38beta2

基因 ID: 19094 | 基因类型: protein coding

关于 Mapk11

Chromosome 15: 89,026,689-89,033,831 reverse strand.GRCm39:CM001008.3

This gene has 4 transcripts (splice variants), 201 orthologues, 19 paralogues and is associated with 3 phenotypes. Broad expression in cortex adult (RPKM 22.5), CNS E14 (RPKM 2.2) and 2 other tissues.

功能概要

该基因编码的蛋白可启动 MAP 激酶活性。参与MAPK级联;骨骼发育;和成骨细胞分化。在心肌细胞增殖的负调节上游或负调节中起作用。在胞质溶胶中有活性。在泌尿生殖系统中表达;肺;神经系统;和感觉器官。与人 MAPK11(丝裂原活化蛋白激酶 11)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables MAP kinase activity. Involved in MAPK cascade; bone development; and osteoblast differentiation. Acts upstream of or within negative regulation of cardiac muscle cell proliferation. Is active in cytosol. Is expressed in genitourinary system; lung; nervous system; and sensory organ. Orthologous to human MAPK11 (mitogen-activated protein kinase 11). [provided by Alliance of Genome Resources, Apr 2022]

Mapk11 基因产物(1)

mRNA Protein Name
NM_011161.5 NP_035291.4 mitogen-activated protein kinase 11
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables MAP kinase activity IMP
IMP: 通过突变表型推断
20551513 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15102471 MGI
enables protein serine/threonine kinase activity EXP
EXP: 通过实验结果推断
16364914 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in MAPK cascade IMP
IMP: 通过突变表型推断
20551513 MGI
involved in bone development IMP
IMP: 通过突变表型推断
20551513 MGI
acts upstream of cardiac muscle cell proliferation IMP
IMP: 通过突变表型推断
21768366 MGI
acts upstream of or within negative regulation of cardiac muscle cell proliferation IMP
IMP: 通过突变表型推断
21768366 MGI
involved in osteoblast differentiation IMP
IMP: 通过突变表型推断
20551513 MGI
acts upstream of or within regulation of cardiac muscle cell proliferation IGI
IGI: 通过遗传相互作用推断
21768366 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytosol IMP
IMP: 通过突变表型推断
20551513 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

mitogen-activated protein kinase 11

MAP kinase 11

MAP kinase p38 beta

MAPK 11

mitogen-activated protein kinase p38 beta

protein kinase, mitogen activated kinase, 11, p38beta

Mapk11 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Mapk11 Q9WUI1 Mapk14 Mus musculus P47811
Y2H
15102471
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mapk11 NCBI NCBI:5600