2. Gene
  3. SDR16C5 - short chain dehydrogenase/reductase family 16C member 5 Gene

SDR16C5 - short chain dehydrogenase/reductase family 16C member 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：短链脱氢酶/还原酶家族 16C 成员 5

种属: Homo sapiens

同用名: RDH#2; RDHE2; EPHD-2; RDH-E2; retSDR2

基因 ID: 195814 | 基因类型: protein coding

关于 SDR16C5

Cytogenetic location: 8q12.1 Genomic coordinates (GRCh38): 8:56,300,005-56,320,175 (from NCBI)

This gene has 3 transcripts (splice variants), 232 orthologues and 25 paralogues. Biased expression in skin (RPKM 15.8), esophagus (RPKM 9.7) and 7 other tissues.

功能概要

该基因编码蛋白质的短链醇脱氢酶/还原酶超家族的成员，并参与视黄醇向视黄醛的氧化。编码的蛋白质与内质网相关，预计包含三个跨膜螺旋，表明它是一种完整的膜蛋白。它识别全反式视黄醇和全反式视黄醛作为底物，并表现出对 NAD (+) /NADH 作为辅助因子的强烈偏好。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 12 月]

This gene encodes a member of the short-chain alcohol dehydrogenase/reductase superfamily of proteins and is involved in the oxidation of retinol to retinaldehyde. The encoded protein is associated with the endoplasmic reticulum and is predicted to contain three transmembrane helices, suggesting that it is an integral membrane protein. It recognizes all-trans-retinol and all-trans-retinaldehyde as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

SDR16C5 基因产物(3)

mRNA Protein Name
NM_001318049.2 NP_001304978.1 epidermal retinol dehydrogenase 2 isoform 1
NM_001318050.2 NP_001304979.1 epidermal retinol dehydrogenase 2 isoform 3
NM_138969.4 NP_620419.2 epidermal retinol dehydrogenase 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
16691198 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
16691198 GOA
enables all-trans-retinol dehydrogenase (NAD+) activity IDA
IDA: 通过直接分析推断
18926804 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables transcription corepressor activity IDA
IDA: 通过直接分析推断
16691198 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in keratinocyte proliferation IMP
IMP: 通过突变表型推断
12372410 GOA
involved in negative regulation of gene expression, epigenetic IDA
IDA: 通过直接分析推断
16691198 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
16691198 GOA
involved in retinal metabolic process IDA
IDA: 通过直接分析推断
18926804 GOA
involved in retinol metabolic process IDA
IDA: 通过直接分析推断
18926804 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
16691198 GOA
colocalizes with endoplasmic reticulum IDA
IDA: 通过直接分析推断
16691198 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
18926804 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16691198 GOA
colocalizes with plasma membrane IDA
IDA: 通过直接分析推断
16691198 GOA
part of transcription repressor complex IDA
IDA: 通过直接分析推断
16691198 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SDR16C5 蛋白结构

adh_short

adh_short: short chain dehydrogenase (42 - 203)

  • 0
  • 100
  • 200
  • 309 a.a.
蛋白主名 其他名称

epidermal retinol dehydrogenase 2

epidermal retinal dehydrogenase 2

SDR16C5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SDR16C5 Q8N3Y7 NDRG4 Homo sapiens Q9ULP0-2
Validated Y2H
32296183
Intra SDR16C5 Q8N3Y7 FUNDC2 Homo sapiens Q9BWH2
Validated Y2H
32296183
Intra SDR16C5 Q8N3Y7 SENP2 Homo sapiens Q9HC62
Validated Y2H
32296183
Intra SDR16C5 Q8N3Y7 HSFX1 Homo sapiens Q9UBD0
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Siberian Tick Typhus

North Asian Tick Typhus

Manchurian Typhus

North Asian Tick Fever

Rickettsia Sibirica Spotted Fever

Spotted Fever Group Rickettsiosis
Psoriasis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12597 SDR16C5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SDR16C5 VGNC VGNC:77343
Bos taurus SDR16C5 VGNC VGNC:34395
Rattus norvegicus SDR16C5 RGD RGD:1565999
Canis familiaris SDR16C5 VGNC VGNC:45955
Felis catus SDR16C5 VGNC VGNC:64955
Mus musculus SDR16C5 MGD MGI:2668443
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