MLKL - mixed lineage kinase domain like pseudokinase Gene

中文名称：混合谱系激酶结构域样假激酶

种属: Homo sapiens

同用名: hMLKL

基因 ID: 197259 | 基因类型: protein coding

关于 MLKL

Cytogenetic location: 16q23.1 Genomic coordinates (GRCh38): 16:74,671,855-74,700,862 (from NCBI)

This gene has 8 transcripts (splice variants), 178 orthologues and 23 paralogues. Broad expression in spleen (RPKM 10.5), bone marrow (RPKM 10.4) and 23 other tissues.

功能概要

该基因属于蛋白激酶超家族。编码的蛋白质包含蛋白激酶样结构域；然而，被认为是无活性的，因为它缺少活性所需的几个残基。该蛋白通过与受体相互作用蛋白 3 (RIP3) 相互作用，在肿瘤坏死因子 (TNF) 诱导的坏死性凋亡中发挥关键作用，这是一种程序性细胞死亡过程，RIP3 是坏死性凋亡途径中的关键信号分子。抑制剂研究和该基因的敲低抑制了 TNF 诱导的坏死。高水平的这种蛋白质和 RIP3 与儿童炎症性肠病有关。已经描述了该基因的可变剪接转录物变体。[RefSeq 提供，2015 年 9 月]

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced Necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in Necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]

MLKL 基因产物(2)

mRNA	Protein	Name
NM_001142497.3	NP_001135969.1	mixed lineage kinase domain-like protein isoform 2
NM_152649.4	NP_689862.1	mixed lineage kinase domain-like protein isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP binding	IDA IDA: 通过直接分析推断	24219132	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	24316671	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	22265413	GOA
enables protein-containing complex binding	IDA IDA: 通过直接分析推断	22265414	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in execution phase of necroptosis	IDA IDA: 通过直接分析推断	24316671	GOA
involved in necroptotic process	IMP IMP: 通过突变表型推断	22265414	GOA
involved in necroptotic signaling pathway	IMP IMP: 通过突变表型推断	22265413	GOA
involved in protein homotrimerization	IDA IDA: 通过直接分析推断	24316671	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	24316671	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	24316671	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MLKL 蛋白结构

Pkinase_Tyr

0
100
200
300
400
471 a.a.

蛋白主名

其他名称

mixed lineage kinase domain-like protein

MLKL 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MLKL	Q8NB16	RIPK3	Homo sapiens	Q9Y572	Anti Tag CoIP	22265413

种属间: 跨种属相互作用 种属内: 同种属相互作用

MLKL 抗体

目录号	产品名	应用	反应物种
HY-P81878	Phospho-MLKL (Ser358) Antibody (YA1623)	WB, IHC-P	Human

关联疾病

疾病名称

别名

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Caspase 8 Deficiency

Autoimmune Lymphoproliferative Syndrome Type 2b	Caspase-8 Deficiency
Ceds	Alps2b
Autoimmune Lymphoproliferative Syndrome, Type Iib	Alps With Recurrent Viral Infections
Autoimmune Lymphoproliferative Syndrome With Recurrent Viral Infections	Caspase 8 Deficiency Syndrome
Caspase 8 Lymphadenopathy Syndrome	Autoimmune Lymphoproliferative Syndrome Type Iib
Caspase Eight Deficiency State	CASP8D

Autoimmune Lymphoproliferative Syndrome

ALPS	Canale-Smith Syndrome
Autoimmune Lymphoproliferative Syndrome, Type Ia	Autoimmune Lymphoproliferative Syndrome, Type Ib
Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant	Css
Autoimmune Lymphoproliferative Syndrome, Type 1b	Autoimmune Lymphoproliferative Syndrome, Type 1a
Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant	Fas Deficiency
Autoimmune Lymphoproliferative Syndrome 1a	ALPS1A
Autoimmune Lymphoproliferative Syndrome Type Ia	Autoimmune Lymphoproliferative Syndrome 1b
ALPS1B	Autoimmune Lymphoproliferative Syndrome Type Ib

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-100573	Necrosulfonamide	Inhibitor	99.47%	否
HY-10587	BIX-01294		98.44%	否
HY-112292	GW806742X	Inhibitor	99.91%	否
HY-144828	RIP1/RIP3/MLKL activator 1		≥97.0%	否
HY-101524	TC13172	Inhibitor	99.04%	否
HY-112292A	GW806742X hydrochloride	Inhibitor	98.77%	否
HY-148365	NecroIr1		98.02%	否
HY-156591	PROTAC MLKL Degrader-1	Degrader	99.76%	否
HY-156119	MLKL-IN-6	Inhibitor	98.57%	否
HY-141889	MLKL-IN-2	Inhibitor	99.83%	否
HY-148366	NecroIr2		98.99%	否
HY-157039	RIPK1-IN-17	Inhibitor	98.38%	否
HY-100573S	Necrosulfonamide-d4	Inhibitor	99.26%	否
HY-100573A	(E/Z)-Necrosulfonamide	Inhibitor	98.84%	否
HY-108239	BIX-01294 trihydrochloride		/	否
HY-139878	MLKL-IN-1	Inhibitor	/	否
HY-148767	MLKL-IN-5	Inhibitor	/	否
HY-149052	SZM-1209	Inhibitor	/	否
HY-149393	RIPK3-IN-3	Inhibitor	/	否
HY-151541	MLKL-IN-3	Inhibitor	/	否
HY-161361	MLKL-IN-7	Inhibitor	/	否
HY-162424	ZBP1/RIP3/MLKL activator 1	Activator	/	否
HY-168640	RIP3 activator 1		/	否
HY-169072	PROTAC MLKL Degrader-2		/	否
HY-169073	TC13172-NH-COOH		/	否
HY-169074	Thalidomide-N-methylpiperazine		/	否
HY-RS08492	MLKL Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-151542	MLKL-IN-4	Inhibitor	/	否
HY-N8380	(-)-Latifolin		/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	MLKL	RGD	RGD:1592221
Mus musculus	MLKL	MGD	MGI:1921818
Bos taurus	MLKL	VGNC	VGNC:31500
Macaca mulatta	MLKL	VGNC	VGNC:82188
Others	MLKL	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MLKL - mixed lineage kinase domain like pseudokinase Gene

关于 MLKL

功能概要

MLKL 基因产物(2)

MLKL 蛋白结构

MLKL 蛋白互作信息

MLKL 抗体

关联疾病

直系同源

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MLKL - mixed lineage kinase domain like pseudokinase Gene

关于 MLKL

功能概要

MLKL 基因产物(2)

MLKL 蛋白结构

MLKL 蛋白互作信息

MLKL 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z