EIF4G1 - eukaryotic translation initiation factor 4 gamma 1 Gene

中文名称：真核翻译起始因子 4 伽玛 1

种属: Homo sapiens

同用名: P220; EIF4F; EIF4G; EIF4GI; PARK18; EIF-4G1

基因 ID: 1981 | 基因类型: protein coding

关于 EIF4G1

Cytogenetic location: 3q27.1 Genomic coordinates (GRCh38): 3:184,314,606-184,335,358 (from NCBI)

This gene has 40 transcripts (splice variants), 221 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in esophagus (RPKM 48.2), skin (RPKM 39.4) and 25 other tissues.

功能概要

该基因编码的蛋白质是多亚基蛋白质复合物 EIF4F 的一个组成部分。该复合物促进 mRNA 募集到核糖体，这是蛋白质合成起始阶段的限速步骤。 mRNA 帽的识别和 5' 末端二级结构的 ATP 依赖性解旋由该复合物中的因子催化。该基因编码的亚基是一种大型支架蛋白，包含 EIF4F 复合体其他成员的结合位点。 N 末端的结构域也可以与 poly (A) 结合蛋白相互作用，这可能在翻译过程中介导 mRNA 的环化。可变剪接导致多个转录本变体，其中一些源自替代启动子的使用。[RefSeq 提供，2010 年 8 月]

The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for Other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]

EIF4G1 基因产物(8)

mRNA	Protein	Name
NM_001194946.2	NP_001181875.2	eukaryotic translation initiation factor 4 gamma 1 isoform 6
NM_001194947.2	NP_001181876.2	eukaryotic translation initiation factor 4 gamma 1 isoform 6
NM_001291157.2	NP_001278086.2	eukaryotic translation initiation factor 4 gamma 1 isoform 7
NM_004953.5	NP_004944.3	eukaryotic translation initiation factor 4 gamma 1 isoform 4
NM_182917.4	NP_886553.3	eukaryotic translation initiation factor 4 gamma 1 isoform 1
NM_198241.3	NP_937884.2	eukaryotic translation initiation factor 4 gamma 1 isoform 5
NM_198242.3	NP_937885.1	eukaryotic translation initiation factor 4 gamma 1 isoform 3
NM_198244.3	NP_937887.2	eukaryotic translation initiation factor 4 gamma 1 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP binding	IDA IDA: 通过直接分析推断	25255371	GOA
enables eukaryotic initiation factor 4E binding	IDA IDA: 通过直接分析推断	23814182	GOA
enables mRNA binding	IDA IDA: 通过直接分析推断	24092755	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10523622	GOA
enables translation factor activity, RNA binding	IMP IMP: 通过突变表型推断	18426977	GOA
enables translation initiation factor activity	IDA IDA: 通过直接分析推断	29987188	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to nutrient levels	IMP IMP: 通过突变表型推断	18426977	GOA
involved in energy homeostasis	IMP IMP: 通过突变表型推断	18426977	GOA
involved in macromolecule biosynthetic process	IGI IGI: 通过遗传相互作用推断	18426977	GOA
involved in miRNA-mediated gene silencing by inhibition of translation	IDA IDA: 通过直接分析推断	23409027	GOA
involved in negative regulation of autophagy	IMP IMP: 通过突变表型推断	18426977	GOA
involved in negative regulation of peptidyl-threonine phosphorylation	IMP IMP: 通过突变表型推断	18426977	GOA
involved in positive regulation of G1/S transition of mitotic cell cycle	IMP IMP: 通过突变表型推断	18426977	GOA
involved in positive regulation of cell growth	IMP IMP: 通过突变表型推断	18426977	GOA
involved in positive regulation of eukaryotic translation initiation factor 4F complex assembly	IMP IMP: 通过突变表型推断	18426977	GOA
involved in positive regulation of eukaryotic translation initiation factor 4F complex assembly	IPI IPI: 通过物理相互作用推断	23041282	GOA
involved in positive regulation of mRNA cap binding	IDA IDA: 通过直接分析推断	23409027	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: 通过突变表型推断	18426977	GOA
involved in positive regulation of protein localization to cell periphery	IGI IGI: 通过遗传相互作用推断	25533483	GOA
involved in positive regulation of protein metabolic process	IMP IMP: 通过突变表型推断	18426977	GOA
involved in positive regulation of translation in response to endoplasmic reticulum stress	IMP IMP: 通过突变表型推断	29062139	GOA
involved in regulation of presynapse assembly	IGI IGI: 通过遗传相互作用推断	25533483	GOA
involved in regulation of translational initiation	IMP IMP: 通过突变表型推断	19648179	GOA
involved in translation	IMP IMP: 通过突变表型推断	18426977	GOA
involved in translation	IPI IPI: 通过物理相互作用推断	24092755	GOA
involved in translational initiation	IDA IDA: 通过直接分析推断	29987188	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	17984221	GOA
located in cytoplasm	IMP IMP: 通过突变表型推断	18426977	GOA
located in cytoplasmic stress granule	IDA IDA: 通过直接分析推断	17984221	GOA
part of eukaryotic translation initiation factor 4F complex	IDA IDA: 通过直接分析推断	25255371	GOA
located in nucleus	IDA IDA: 通过直接分析推断	17984221	GOA
located in nucleus	IMP IMP: 通过突变表型推断	18426977	GOA
located in ribosome	IMP IMP: 通过突变表型推断	18426977	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EIF4G1 蛋白结构

MIF4G

MA3

0
300
600
900
1200
1500
1599 a.a.

蛋白主名

其他名称

eukaryotic translation initiation factor 4 gamma 1

EIF4-gamma

EIF4G1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	EIF4G1	Q04637	HNRNPD	Homo sapiens	Q14103-4	Pull Down	16556936
种属内	EIF4G1	Q04637	EIF4E	Homo sapiens	P06730	Pull Down	21191102
种属内	EIF4G1	Q04637	EIF4E	Homo sapiens	P06730	CoIP	15361857
种属内	EIF4G1	Q04637	EIF4A1	Homo sapiens	P60842	SPR	19203580
种属内	EIF4G1	Q04637	EIF4A1	Homo sapiens	P60842	Anti Bait CoIP	17353931
种属内	EIF4G1	Q04637	EIF4A1	Homo sapiens	P60842	GMS	19203580
种属内	EIF4G1	Q04637	EIF4A1	Homo sapiens	P60842	CoIP	11408474
种属内	EIF4G1	Q04637	EIF4A1	Homo sapiens	P60842	NMR	19203580
种属内	EIF4G1	Q04637	EIF4A1	Homo sapiens	P60842	Pull Down	11408474
种属内	EIF4G1	Q04637	PABPC1	Homo sapiens	P11940	SPR	16772376
种属内	EIF4G1	Q04637	PABPC1	Homo sapiens	P11940	Pull Down	16772376
种属内	EIF4G1	Q04637	PABPC1	Homo sapiens	P11940	Pull Down	19716330
种属内	EIF4G1	Q04637	PABPC1	Homo sapiens	P11940	Pull Down	9857202

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 EIF4G1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71731	EIF4G1 Protein, Human (P.pastoris, His)	Q04637 (I1250-N1599)	≥95%

EIF4G1 抗体

目录号	产品名	应用	反应物种
HY-P80652	eIF4G1 Antibody	WB, IHC-P, ICC/IF	Human

关联疾病

疾病名称

别名

Parkinson Disease 18, Autosomal Dominant

Parkinson Disease 18, Autosomal Dominant, Susceptibility To	Parkinson Disease 18
PARK18	Parkinson Disease 18 Autosomal Dominant
Parkinson Disease, Type 18

Hereditary Late-Onset Parkinson Disease

Autosomal Dominant Late-Onset Parkinson Disease	Lopd
Hereditary Late Onset Parkinson Disease

Mouth Disease

Mouth Diseases

Mouth Disorders

Fragile X Syndrome

FXS	Martin-Bell Syndrome
Fraxa Syndrome	Marker X Syndrome
X-Linked Mental Retardation And Macroorchidism	Fragile X Mental Retardation Syndrome
Fra Syndrome	Mental Retardation, X-Linked, Associated With Marxq28
X-Linked Intellectual Disability And Macroorchidism	Frax Syndrome
Symptomatic Form Of Fragile X Syndrome In Female Carriers	Fragile-X Syndrome
Fraxe Syndrome

Viral Infectious Disease

Viral Disease	Arbovirus Infections
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Poliomyelitis

Polio

Infantile Paralysis

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy	Vanishing White Matter Disease
Ovarioleukodystrophy	Vanishing White Matter Leukodystrophy
Childhood Ataxia With Central Nervous System Hypomyelinization	Cach
Cach Syndrome	Myelinosis Centralis Diffusa
VWM	Cle
Childhood Ataxia With Central Nervous System Hypomyelination	Childhood Ataxia With Diffuse Central Nervous System Hypomyelination
Cach/Vwm	Cach/Vwm Syndrome
Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter	Cree Leukoencehalopathy
Late Infantile Cach Syndrome	Juvenile Or Adult Cach Syndrome
Congenital Or Early Infantile Cach Syndrome	Leukodystrophy With Vanishing White Matter

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-19560	SBI-0640756	Inhibitor	99.75%	否
HY-RS04281	EIF4G1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-164524	SBI-0640726	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	EIF4G1	RGD	RGD:1306144
Canis familiaris	EIF4G1	VGNC	VGNC:40289
Felis catus	EIF4G1	VGNC	VGNC:97415
Bos taurus	EIF4G1	VGNC	VGNC:28415
Macaca mulatta	EIF4G1	VGNC	VGNC:72195
Mus musculus	EIF4G1	MGD	MGI:2384784
Others	EIF4G1	NCBI

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

EIF4G1 - eukaryotic translation initiation factor 4 gamma 1 Gene

关于 EIF4G1

功能概要

EIF4G1 基因产物(8)

EIF4G1 蛋白结构

EIF4G1 蛋白互作信息

重组 EIF4G1 蛋白

EIF4G1 抗体

关联疾病

直系同源

热门区域

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EIF4G1 - eukaryotic translation initiation factor 4 gamma 1 Gene

关于 EIF4G1

功能概要

EIF4G1 基因产物(8)

EIF4G1 蛋白结构

EIF4G1 蛋白互作信息

重组 EIF4G1 蛋白

EIF4G1 抗体

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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