2. Gene
  3. Ccl2 - chemokine (C-C motif) ligand 2 Gene

Ccl2 - chemokine (C-C motif) ligand 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: JE; HC11; MCAF; MCP1; MCP-1; Scya2; Sigje; SMC-CF

基因 ID: 20296 | 基因类型: protein coding

关于 Ccl2

功能概要

This gene is one of several cytokine genes clustered on chromosome 11. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and memory T cells but not for neutrophils. The human ortholog has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis, and atherosclerosis. [provided by RefSeq, Sep 2015]

Ccl2 基因产物(1)

mRNA Protein Name
NM_011333.3 NP_035463.1 C-C motif chemokine 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables CCR2 chemokine receptor binding IPI
IPI: 通过物理相互作用推断
8662823 MGI
enables G protein-coupled receptor binding IDA
IDA: 通过直接分析推断
8631787 MGI
enables cytokine activity IDA
IDA: 通过直接分析推断
23395675 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8631787 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to interleukin-1 IDA
IDA: 通过直接分析推断
14662900 MGI
involved in cellular response to lipopolysaccharide IDA
IDA: 通过直接分析推断
14662900 MGI
involved in cellular response to tumor necrosis factor IDA
IDA: 通过直接分析推断
14662900 MGI
involved in cellular response to type II interferon IDA
IDA: 通过直接分析推断
14662900 MGI
involved in helper T cell extravasation IDA
IDA: 通过直接分析推断
18586982 MGI
involved in negative regulation of angiogenesis IMP
IMP: 通过突变表型推断
14566334 MGI
involved in positive regulation of T cell activation IMP
IMP: 通过突变表型推断
14662900 MGI
involved in positive regulation of apoptotic cell clearance IDA
IDA: 通过直接分析推断
20691665 MGI
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
30687013 MGI
involved in positive regulation of immune complex clearance by monocytes and macrophages IMP
IMP: 通过突变表型推断
14566334 MGI
involved in positive regulation of macrophage chemotaxis IDA
IDA: 通过直接分析推断
14566334 MGI
involved in positive regulation of monocyte chemotaxis IDA
IDA: 通过直接分析推断
25651887 MGI
involved in positive regulation of nitric-oxide synthase biosynthetic process IMP
IMP: 通过突变表型推断
19164781 MGI
involved in positive regulation of synaptic transmission, glutamatergic IDA
IDA: 通过直接分析推断
29993042 MGI
involved in regulation of vascular endothelial growth factor production IMP
IMP: 通过突变表型推断
14566334 MGI
acts upstream of or within response to bacterium IEP
IEP: 通过表达模式推断
23012479 MGI
acts upstream of or within response to wounding IDA
IDA: 通过直接分析推断
19404405 MGI
involved in sensory perception of pain IDA
IDA: 通过直接分析推断
29993042 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
19139201 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

C-C motif chemokine 2

monocyte chemoattractant protein 1

monocyte chemotactic protein 1

platelet-derived growth factor-inducible protein JE

small-inducible cytokine A2

重组 Ccl2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7235 MCP-1/CCL2 Protein, Mouse (HEK293) P10148 (Q24-R96) ≥95%
HY-P7764 MCP-1/CCL2 Protein, Mouse P10148 (Q24-R96) ≥95%
HY-P72757 MCP-1/CCL2 Protein, Mouse (HEK293, His) P10148 (Q24-N148) ≥95%
HY-P74758 MCP-1/CCL2 Protein, Mouse (sf9, His) Q5SVU3 (Q24-N148) ≥95%
HY-P76489 MCP-1/CCL2 Protein, Mouse (Biotinylated, sf9, His) Q5SVU3 (Q24-N148) ≥95%
HY-P700164AF Animal-Free MCP-1/CCL2 Protein, Mouse (His) P10148 (Q24-N148) ≥95%

相关产品

Approval
生物活性分子 (4)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0673 Pirfenidone Inhibitor 99.98% 是
HY-B1322A Amodiaquine 99.98% 否
HY-B1322 Amodiaquine dihydrochloride dihydrate 99.89% 否
HY-B1322B Amodiaquine dihydrochloride 99.89% 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-B0498 Bindarit Inhibitor 99.53% Phase 3
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P99188 Carlumab Inhibitor 97.80% Phase 2
HY-P99450 Avdoralimab Inhibitor 95.16% Phase 2
Pre-clinical Phase
生物活性分子 (17)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-120501 B022 Inhibitor 99.37% 否
HY-W007376 Indole-3-carboxaldehyde 99.96% 否
HY-115644 BMS-470539 dihydrochloride Agonist 99.95% 否
HY-120897 NS-3-008 hydrochloride Inhibitor 99.65% 否
HY-149202 UT-11 Inhibitor 99.62% 否
HY-B0673S Pirfenidone-d5 Inhibitor 99.48% 否
HY-116247 ST247 Agonist 99.88% 否
HY-160552 244cis / 否
HY-108554 Q94 hydrochloride Antagonist / 否
HY-121896 DSHN Activator / 否
HY-144334 CHIKV-IN-3 Inhibitor / 否
HY-163655 Glutaminyl Cyclase Inhibitor 6 Inhibitor / 否
HY-B1322AS1 Amodiaquine-d10 hydrochloride / 否
HY-N3887 Evoxine Inhibitor / 否
HY-RS02089 CCL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W013675 2-Methoxyhydroquinone Inhibitor / 否
HY-W104821 Rosolic acid Activator / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ccl2 NCBI NCBI:6347
Macaca fascicularis Ccl2 NCBI NCBI:102135739
Susscrofa domestica Ccl2 NCBI
Rattus norvegicus Ccl2 NCBI NCBI:24770
Macaca mulatta Ccl2 NCBI NCBI:574138
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