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  3. EPHA5 - EPH receptor A5 Gene

EPHA5 - EPH receptor A5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：EPH 受体 A5

种属: Homo sapiens

同用名: EK7; CEK7; EHK1; HEK7; EHK-1; TYRO4

基因 ID: 2044 | 基因类型: protein coding

关于 EPHA5

Cytogenetic location: 4q13.1-q13.2 Genomic coordinates (GRCh38): 4:65,319,567-65,670,489 (from NCBI)

This gene has 6 transcripts (splice variants), 204 orthologues and 53 paralogues. Biased expression in brain (RPKM 4.9), ovary (RPKM 1.0) and 6 other tissues.

功能概要

该基因属于蛋白酪氨酸激酶家族的肝配蛋白受体亚家族。 EPH 和 EPH 相关受体与介导发育事件有关，特别是在神经系统中。 EPH 亚家族中的受体通常具有单个激酶结构域和一个含有富含半胱氨酸结构域和 2 个纤连蛋白 III 型重复序列的胞外区域。基于肝配蛋白受体胞外结构域序列的相似性及其结合肝配蛋白-A 和肝配蛋白-B 配体的亲和力，肝配蛋白受体分为 2 组。已经描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2013 年 8 月]

This gene belongs to the Ephrin Receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]

EPHA5 基因产物(6)

mRNA Protein Name
NM_001281765.3 NP_001268694.1 ephrin type-A receptor 5 isoform c
NM_001281766.3 NP_001268695.1 ephrin type-A receptor 5 isoform d
NM_001281767.3 NP_001268696.1 ephrin type-A receptor 5 isoform e
NM_001318761.2 NP_001305690.1 ephrin type-A receptor 5 isoform f
NM_004439.8 NP_004430.4 ephrin type-A receptor 5 isoform a
NM_182472.5 NP_872272.2 ephrin type-A receptor 5 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
35384245 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in neuron development IEP
IEP: 通过表达模式推断
10375373 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendrite IDA
IDA: 通过直接分析推断
9191074 GOA
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
10064801 GOA
located in neuronal cell body IDA
IDA: 通过直接分析推断
10375373 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
10375373 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
10375373 GOA
located in rough endoplasmic reticulum IDA
IDA: 通过直接分析推断
10375373 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EPHA5 蛋白结构

Ephrin_lbd

Ephrin_lbd: Ephrin receptor ligand binding domain (60 - 233)

fn3

fn3: Fibronectin type III domain (359 - 448)

fn3

fn3: Fibronectin type III domain (470 - 552)

EphA2_TM

EphA2_TM: Ephrin type-A receptor 2 transmembrane domain (575 - 672)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (675 - 932)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (966 - 1027)

  • 0
  • 200
  • 400
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  • 800
  • 1037 a.a.
蛋白主名 其他名称

ephrin type-A receptor 5

EPH homology kinase 1

重组 EPHA5 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77930 EPHA5 Protein, Human (HEK293, His) P54756-1 (A26-P573) ≥95%

关联疾病

疾病名称 别名
Lung Cancer Susceptibility 3

Lung Adenocarcinoma

Adenocarcinoma Of Lung

LNCR3

Adenocarcinoma Of Lung, Susceptibility To

Bronchogenic Lung Adenocarcinoma

Nonsmall Cell Adenocarcinoma

Adenocarcinoma Lung

Lung Adenocarcinomas

Non-Small Cell Adenocarcinoma
Leber Congenital Amaurosis 17

LCA17

Leber Congenital Amaurosis, Type 17
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04429 EPHA5 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-146375 UniPR505 Antagonist / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris EPHA5 VGNC VGNC:40408
Bos taurus EPHA5 VGNC VGNC:28535
Felis catus EPHA5 VGNC VGNC:78486
Mus musculus EPHA5 MGD MGI:99654
Macaca mulatta EPHA5 VGNC VGNC:72238
Rattus norvegicus EPHA5 RGD RGD:620831
Macaca fascicularis EPHA5 NCBI NCBI:102138762
Others EPHA5 NCBI
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