2. Gene
  3. Sos1 - SOS Ras/Rac guanine nucleotide exchange factor 1 Gene

Sos1 - SOS Ras/Rac guanine nucleotide exchange factor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: 9630010N06; 4430401P03Rik

基因 ID: 20662 | 基因类型: protein coding

关于 Sos1

功能概要

Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including animal organ development; regulation of T cell activation; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in several cellular components, including neuronal cell body; plasma membrane; and postsynaptic density. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and retina. Used to study Noonan syndrome 4. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 4; and gingival fibromatosis. Orthologous to human SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Sos1 基因产物(1)

mRNA Protein Name
NM_009231.2 NP_033257.2 son of sevenless homolog 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables guanyl-nucleotide exchange factor activity EXP
EXP: 通过实验结果推断
15644420 MGI
enables guanyl-nucleotide exchange factor activity IDA
IDA: 通过直接分析推断
7799946 MGI
enables guanyl-nucleotide exchange factor activity IMP
IMP: 通过突变表型推断
7799946 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8479540 MGI
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
15661907 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within B cell homeostasis IGI
IGI: 通过遗传相互作用推断
24043312 MGI
involved in B cell receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
24043312 MGI
involved in Schwann cell development IMP
IMP: 通过突变表型推断
10704452 MGI
acts upstream of or within blood vessel morphogenesis IMP
IMP: 通过突变表型推断
9030684 MGI
acts upstream of or within cardiac atrium morphogenesis IMP
IMP: 通过突变表型推断
9030684 MGI
acts upstream of or within epidermal growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
9030684 MGI
acts upstream of or within eyelid development in camera-type eye IGI
IGI: 通过遗传相互作用推断
9030684 MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
11585837 MGI
acts upstream of or within hair follicle development IGI
IGI: 通过遗传相互作用推断
9030684 MGI
acts upstream of or within heart morphogenesis IMP
IMP: 通过突变表型推断
9030684 MGI
acts upstream of or within heart trabecula morphogenesis IMP
IMP: 通过突变表型推断
9030684 MGI
involved in insulin receptor signaling pathway IDA
IDA: 通过直接分析推断
7829473 MGI
involved in insulin-like growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
33567274 MGI
acts upstream of or within lymphocyte homeostasis IGI
IGI: 通过遗传相互作用推断
24043312 MGI
acts upstream of or within midbrain morphogenesis IMP
IMP: 通过突变表型推断
9030684 MGI
acts upstream of or within multicellular organism growth IMP
IMP: 通过突变表型推断
9030684 MGI
involved in myelination IMP
IMP: 通过突变表型推断
10704452 MGI
acts upstream of or within pericardium morphogenesis IMP
IMP: 通过突变表型推断
9030684 MGI
acts upstream of or within regulation of T cell differentiation in thymus IGI
IGI: 通过遗传相互作用推断
24043312 MGI
acts upstream of or within regulation of T cell proliferation IGI
IGI: 通过遗传相互作用推断
24043312 MGI
acts upstream of or within regulation of pro-B cell differentiation IGI
IGI: 通过遗传相互作用推断
24043312 MGI
acts upstream of or within roof of mouth development IMP
IMP: 通过突变表型推断
9030684 MGI
acts upstream of or within small GTPase-mediated signal transduction IMP
IMP: 通过突变表型推断
15728722 MGI
acts upstream of or within vitellogenesis IMP
IMP: 通过突变表型推断
9030684 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

son of sevenless homolog 1

guanine nucleotide releasing factor

ras guanine exchange factor

son-of-sevenless 1

Sos1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Sos1 Q62245 Grb2 Mus musculus Q60631
Anti Bait CoIP
9569023
种属内
Sos1 Q62245 Grb2 Mus musculus Q60631
Anti Bait CoIP
8479540
种属间
Sos1 Q62245 polg_hcvbk Hepatitis C virus P26663
Fluorescence Spectr
15767257
种属间
Sos1 Q62245 polg_hcvbk Hepatitis C virus P26663
NMR
15767257
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-134813 MRTX1133 Inhibitor 99.97% Phase 2
Pre-clinical Phase
生物活性分子 (72)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-125817 BI-3406 Inhibitor 99.95% 否
HY-145926 MRTX0902 Inhibitor 99.75% 否
HY-114398 BAY-293 Inhibitor 98.97% 否
HY-134885 RMC-0331 Inhibitor 98.96% 否
HY-P2265A SAH-SOS1A TFA Inhibitor 99.16% 否
HY-151881 SOS1-IN-15 Inhibitor 99.51% 否
HY-151517 SOS1-IN-14 Inhibitor 99.60% 否
HY-111671 SOS1 activator 1 Activator 98.01% 否
HY-148278 BI-0474 Inhibitor 99.83% 否
HY-153606 SOS1 agonist-1 Activator 97.24% 否
HY-145737A PROTAC SOS1 degrader-1 TFA Agonist 99.38% 否
HY-144962 SOS1-IN-11 Inhibitor 98.22% 否
HY-W056267 3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde ≥98.0% 否
HY-101796 NSC-70220 Inhibitor 99.42% 否
HY-161235 BTX-7312 Degrader 98.35% 否
HY-134813A MRTX1133 formic Inhibitor 98.23% 否
HY-161233 BTX-6654 Inhibitor / 否
HY-114398A (S)-BAY-293 Control / 否
HY-158310 SOS1/EGFR-IN-1 Inhibitor 99.54% 否
HY-144212 SOS1-IN-8 Inhibitor / 否
HY-124514 UC-857993 Inhibitor / 否
HY-144207 SOS1-IN-9 Inhibitor / 否
HY-144210 SOS1-IN-6 Inhibitor / 否
HY-144211 SOS1-IN-7 Inhibitor / 否
HY-144213 SOS1-IN-10 Inhibitor / 否
HY-144657 (4S)-PROTAC SOS1 degrader-1 Inhibitor / 否
HY-144657A (4S)-PROTAC SOS1 degrader-1 diTFA Inhibitor 98.09% 否
HY-144965 SOS1-IN-12 Inhibitor / 否
HY-144967 SOS1-IN-13 Inhibitor / 否
HY-145022 KRAS G12C inhibitor 25 Inhibitor / 否
HY-145046 SOS1-IN-3 Inhibitor / 否
HY-145047 SOS1-IN-4 Inhibitor / 否
HY-145048 SOS1-IN-5 Inhibitor / 否
HY-145737 PROTAC SOS1 degrader-1 Agonist / 否
HY-148261 KRAS G12C inhibitor 56 Inhibitor / 否
HY-151968 KRAS G12C inhibitor 57 Inhibitor / 否
HY-152145 PROTAC SOS1 degrader-3 / 否
HY-153674 PROTAC SOS1 degrader-4 Degrader / 否
HY-153940 SOS1/KRAS-IN-1 Inhibitor / 否
HY-153989 SOS1-IN-16 Inhibitor / 否
HY-161173 PROTAC SOS1 degrader-5 / 否
HY-161236 KRAS ligand 4 Inhibitor / 否
HY-161450 LHF418 Inhibitor / 否
HY-161452 SOS1 Ligand intermediate-3 / 否
HY-161634 PROTAC SOS1 degrader-8 Degrader / 否
HY-161635 SOS1 Ligand intermediate-4 Inhibitor / 否
HY-161636 PROTAC SOS1 degrader-9 Degrader / 否
HY-161637 E3 ligase Ligand 25 / 否
HY-161639 E3 ligase Ligand 26 / 否
HY-161654 PROTAC SOS1 degrader-10 Degrader / 否
HY-161714 HH0043 Inhibitor / 否
HY-162281 PROTAC SOS1 degrader-6 Degrader / 否
HY-163582 PROTAC SOS1 degrader-7 / 否
HY-163939 RGT-018 Inhibitor / 否
HY-167768 SOS1 activator 2 Modulator / 否
HY-168514 SOS1/EGFR-IN-2 Inhibitor / 否
HY-168637 SIAIS562055 Inhibitor / 否
HY-168638 PROTAC SOS1 ligand 1 / 否
HY-168716 SOS1-IN-17 Inhibitor / 否
HY-169371 SOS1 Ligand intermediate-7 / 否
HY-19539 NSC-658497 Inhibitor / 否
HY-49515 SOS1 Ligand intermediate-2 / 否
HY-P2265 SAH-SOS1A Inhibitor / 否
HY-RS13576 SOS1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-132129 SOS1-IN-2 Inhibitor / 否
HY-161638 E3 Ligase Ligand-linker Conjugate 108 / 否
HY-161640 E3 Ligase Ligand-linker Conjugate 109 / 否
HY-161655 SOS1 Ligand intermediate-5 / 否
HY-161656 PIP-C-3-Azaspiro[5.5]undecane-boc / 否
HY-161657 2-Methoxyphenyl dihydrouracil-azaspiro[5.5]undecane-C-PIP / 否
HY-163583 SOS1 Ligand intermediate-6 / 否
HY-49514 SOS1 Ligand intermediate-1 / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sos1 NCBI NCBI:6654
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