1. Gene
  2. EREG - epiregulin Gene

EREG - epiregulin Gene

中文名称:上皮调节素

种属: Homo sapiens

同用名: ER; Ep; EPR

基因 ID: 2069 | 基因类型: protein coding

关于 EREG

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:74,365,145-74,388,749 (from NCBI)

This gene has 3 transcripts (splice variants), 138 orthologues and 5 paralogues. Biased expression in bone marrow (RPKM 51.6), esophagus (RPKM 7.6) and 3 other tissues.

功能概要

该基因编码一种分泌肽激素和表皮生长因子 (EGF) 蛋白质家族的成员。编码的蛋白质是表皮生长因子受体 (EGFR) 和结构相关的 erb-b2 受体酪氨酸激酶 4 (ERBB4) 的配体。编码的蛋白质可能参与广泛的生物过程,包括炎症、伤口愈合、卵母细胞成熟和细胞增殖。此外,编码的蛋白质可能促进各种人体组织癌症的进展。[RefSeq 提供,2015 年 7 月]

This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015]

EREG 基因产物(1)

mRNA Protein Name
NM_001432.3 NP_001423.1 proepiregulin preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9419975 GOA
enables receptor ligand activity IDA
IDA: 通过直接分析推断
9556621 GOA
enables transmembrane receptor protein tyrosine kinase activator activity IDA
IDA: 通过直接分析推断
9556621 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ERBB2-EGFR signaling pathway IDA
IDA: 通过直接分析推断
9556621 GOA
involved in ERBB2-ERBB4 signaling pathway IDA
IDA: 通过直接分析推断
9556621 GOA
involved in ERBB4-ERBB4 signaling pathway IDA
IDA: 通过直接分析推断
9556621 GOA
involved in cell-cell signaling IDA
IDA: 通过直接分析推断
14581411 GOA
involved in cytokine-mediated signaling pathway IDA
IDA: 通过直接分析推断
9419975 GOA
involved in epidermal growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
9556621 GOA
involved in keratinocyte proliferation IDA
IDA: 通过直接分析推断
10681561 GOA
involved in mRNA transcription IDA
IDA: 通过直接分析推断
10681561 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
14581411 GOA
involved in negative regulation of smooth muscle cell differentiation IDA
IDA: 通过直接分析推断
14581411 GOA
involved in positive regulation of DNA replication IDA
IDA: 通过直接分析推断
9337852 GOA
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
10681561 GOA
involved in positive regulation of cytokine production IDA
IDA: 通过直接分析推断
10681561 GOA
involved in positive regulation of fibroblast proliferation IDA
IDA: 通过直接分析推断
12702554 GOA
involved in positive regulation of phosphorylation IDA
IDA: 通过直接分析推断
9419975 GOA
involved in positive regulation of protein kinase activity IDA
IDA: 通过直接分析推断
14581411 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in extracellular space IDA
IDA: 通过直接分析推断
9556621 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
9337852 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

proepiregulin

EREG 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
EREG O14944 NINJ2 Homo sapiens Q9NZG7 32296183
种属内
EREG O14944 MS4A13 Homo sapiens Q5J8X5 32296183
种属内
EREG O14944 OLFM4 Homo sapiens Q6UX06 32296183
种属内
EREG O14944 EGFR Homo sapiens P00533 28988771
种属内
EREG O14944 CXCL9 Homo sapiens Q07325 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 EREG 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7011 Epiregulin Protein, Human O14944 (V60-L108) ≥95%
HY-P73031 Epiregulin Protein, Human (HEK293, Fc) O14944/NP_001423.1 (V63-L108) ≥95%

关联疾病

疾病名称 别名
Malignant Fibrous Histiocytoma

Undifferentiated Pleomorphic Sarcoma

Ups

Histiocytoma, Malignant Fibrous

Fibroxanthosarcoma

Mfh

Malignant Fibrohistiocytic Tumors

Histiocytoma, Fibrous, Malignant

Squamous Blepharitis
Vallecula Cancer

Malignant Tumor Of Vallecula

Bronchiectasis 2
Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder

Mixed Cell Adenoma
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta EREG VGNC VGNC:106572
Felis catus EREG VGNC VGNC:61935
Rattus norvegicus EREG RGD RGD:620299
Mus musculus EREG MGD MGI:107508
Bos taurus EREG VGNC VGNC:28575
Others EREG NCBI