1. Gene
  2. Stat5b - signal transducer and activator of transcription 5B Gene

Stat5b - signal transducer and activator of transcription 5B Gene

中文名称:信号转导和转录激活因子 5 B

种属: Mus musculus

基因 ID: 20851 | 基因类型: protein coding

关于 Stat5b

Chromosome 11: 100,671,557-100,741,550 reverse strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 286 orthologues, 6 paralogues and is associated with 26 phenotypes. Ubiquitous expression in thymus adult (RPKM 41.1), ovary adult (RPKM 18.1) and 27 other tissues.

功能概要

该基因编码的蛋白可启动 DNA 结合转录激活剂活性,RNA 聚合酶 II 特异性; RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性;和蛋白质二聚化活性。参与细胞对生长因子刺激的反应;通过 JAK-STAT 的生长激素受体信号通路;和 RNA 聚合酶 II 对转录的正调控。作用于多个过程的上游或内部,包括动物器官发育;积极调节防御反应;和淋巴细胞活化的正调节。位于细胞质和细胞核中。以多种结构表达,包括大脑;泌尿生殖系统;直觉;淋巴系统腺体;以及肝脏和胆道系统。该基因的人类直向同源基因与免疫失调的生长激素不敏感综合征 1 和免疫失调的生长激素不敏感综合征 2 相关。与人类 STAT5B(信号转导和转录激活因子 5B)直系同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in cellular response to growth factor stimulus; growth hormone receptor signaling pathway via JAK-STAT; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; positive regulation of defense response; and positive regulation of lymphocyte activation. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in growth hormone insensitivity syndrome with immune dysregulation 1 and growth hormone insensitivity syndrome with immune dysregulation 2. Orthologous to human STAT5B (signal transducer and activator of transcription 5B). [provided by Alliance of Genome Resources, Apr 2022]

Stat5b 基因产物(3)

mRNA Protein Name
NM_001113563.2 NP_001107035.1 signal transducer and activator of transcription 5B
NM_011489.3 NP_035619.3 signal transducer and activator of transcription 5B
NM_001362682.1 NP_001349611.1 signal transducer and activator of transcription 5B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
10485657 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
19666510 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
19666510 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17666591 MGI
enables protein dimerization activity IDA
IDA: 通过直接分析推断
20639532 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of B cell differentiation IGI
IGI: 通过遗传相互作用推断
10979977 MGI
acts upstream of or within Peyer's patch development IGI
IGI: 通过遗传相互作用推断
15294943 MGI
acts upstream of or within T cell differentiation in thymus IGI
IGI: 通过遗传相互作用推断
15294943 MGI
acts upstream of or within T cell homeostasis IGI
IGI: 通过遗传相互作用推断
10072077 MGI
acts upstream of activated T cell proliferation IGI
IGI: 通过遗传相互作用推断
10072077 MGI
acts upstream of activated T cell proliferation IMP
IMP: 通过突变表型推断
9841920 MGI
acts upstream of cell population proliferation IGI
IGI: 通过遗传相互作用推断
10652277 MGI
acts upstream of or within cell surface receptor signaling pathway via JAK-STAT IDA
IDA: 通过直接分析推断
10485657 MGI
involved in cellular response to growth factor stimulus IDA
IDA: 通过直接分析推断
20639532 MGI
acts upstream of or within cytokine-mediated signaling pathway IDA
IDA: 通过直接分析推断
10485657 MGI
acts upstream of or within development of secondary female sexual characteristics IMP
IMP: 通过突变表型推断
9630227 MGI
acts upstream of or within development of secondary male sexual characteristics IGI
IGI: 通过遗传相互作用推断
9630227 MGI
acts upstream of or within development of secondary male sexual characteristics IMP
IMP: 通过突变表型推断
9630227 MGI
acts upstream of erythrocyte differentiation IGI
IGI: 通过遗传相互作用推断
10072077 MGI
acts upstream of or within female pregnancy IGI
IGI: 通过遗传相互作用推断
15471942 MGI
acts upstream of or within female pregnancy IMP
IMP: 通过突变表型推断
15471942 MGI
acts upstream of gamma-delta T cell differentiation IGI
IGI: 通过遗传相互作用推断
15294943 MGI
involved in growth hormone receptor signaling pathway via JAK-STAT IDA
IDA: 通过直接分析推断
8923468 MGI
acts upstream of interleukin-2 production IGI
IGI: 通过遗传相互作用推断
10072077 MGI
acts upstream of or within lactation IMP
IMP: 通过突变表型推断
9630227 MGI
acts upstream of or within lipid storage IGI
IGI: 通过遗传相互作用推断
9630227 MGI
acts upstream of or within luteinization IGI
IGI: 通过遗传相互作用推断
9630227 MGI
acts upstream of lymphocyte differentiation IGI
IGI: 通过遗传相互作用推断
15294943 MGI
acts upstream of or within mast cell migration IMP
IMP: 通过突变表型推断
24068671 MGI
acts upstream of mitotic cell cycle IGI
IGI: 通过遗传相互作用推断
10072077 MGI
acts upstream of myeloid cell apoptotic process IGI
IGI: 通过遗传相互作用推断
10652277 MGI
acts upstream of or within natural killer cell differentiation IGI
IGI: 通过遗传相互作用推断
10072077 MGI
acts upstream of natural killer cell differentiation IMP
IMP: 通过突变表型推断
9841920 MGI
acts upstream of natural killer cell mediated cytotoxicity IMP
IMP: 通过突变表型推断
9841920 MGI
acts upstream of natural killer cell proliferation IMP
IMP: 通过突变表型推断
9841920 MGI
acts upstream of or within negative regulation of erythrocyte differentiation IGI
IGI: 通过遗传相互作用推断
10072077 MGI
acts upstream of or within negative regulation of myeloid cell apoptotic process IGI
IGI: 通过遗传相互作用推断
10652277 MGI
acts upstream of or within positive regulation of B cell differentiation IGI
IGI: 通过遗传相互作用推断
10979977 MGI
acts upstream of or within positive regulation of activated T cell proliferation IGI
IGI: 通过遗传相互作用推断
10072077 MGI
acts upstream of or within positive regulation of activated T cell proliferation IMP
IMP: 通过突变表型推断
9841920 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
10652277 MGI
acts upstream of or within positive regulation of gamma-delta T cell differentiation IGI
IGI: 通过遗传相互作用推断
15294943 MGI
acts upstream of or within positive regulation of inflammatory response IGI
IGI: 通过遗传相互作用推断
10652277 MGI
acts upstream of or within positive regulation of interleukin-2 production IGI
IGI: 通过遗传相互作用推断
10072077 MGI
acts upstream of or within positive regulation of lymphocyte differentiation IGI
IGI: 通过遗传相互作用推断
15294943 MGI
acts upstream of or within positive regulation of mitotic cell cycle IGI
IGI: 通过遗传相互作用推断
10072077 MGI
acts upstream of or within positive regulation of multicellular organism growth IGI
IGI: 通过遗传相互作用推断
9630227 MGI
acts upstream of or within positive regulation of multicellular organism growth IMP
IMP: 通过突变表型推断
9630227 MGI
acts upstream of or within positive regulation of natural killer cell differentiation IMP
IMP: 通过突变表型推断
9841920 MGI
acts upstream of or within positive regulation of natural killer cell mediated cytotoxicity IMP
IMP: 通过突变表型推断
9841920 MGI
acts upstream of or within positive regulation of natural killer cell proliferation IMP
IMP: 通过突变表型推断
9841920 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19666510 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
20639532 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
10485657 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
9630227 MGI
acts upstream of or within progesterone metabolic process IGI
IGI: 通过遗传相互作用推断
15471942 MGI
acts upstream of or within regulation of cell adhesion IMP
IMP: 通过突变表型推断
11706048 MGI
acts upstream of or within regulation of epithelial cell differentiation IMP
IMP: 通过突变表型推断
11706048 MGI
involved in regulation of multicellular organism growth IGI
IGI: 通过遗传相互作用推断
18648510 MGI
acts upstream of or within regulation of steroid metabolic process IGI
IGI: 通过遗传相互作用推断
15471942 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
15294943 MGI
acts upstream of or within response to interleukin-15 IMP
IMP: 通过突变表型推断
9841920 MGI
acts upstream of or within response to interleukin-2 IMP
IMP: 通过突变表型推断
9841920 MGI
acts upstream of or within response to interleukin-4 IMP
IMP: 通过突变表型推断
9841920 MGI
acts upstream of or within sex differentiation IMP
IMP: 通过突变表型推断
17412818 MGI
acts upstream of positive effect taurine metabolic process IGI
IGI: 通过遗传相互作用推断
18648510 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
10485657 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
9630227 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12634107 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12147240 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Stat5b 蛋白结构

STAT_int

STAT_int: pfam02865 (1 - 123)

STAT5_CCD

STAT5_CCD: cd16855 (138 - 329)

STAT5_DBD

STAT5_DBD: cd16849 (331 - 488)

SH2_STAT5b

SH2_STAT5b: cd10420 (572 - 716)

  • 0
  • 200
  • 400
  • 600
  • 786 a.a.
蛋白主名 其他名称

signal transducer and activator of transcription 5B

mammary gland factor STAT5B

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Stat5b NCBI NCBI:6777