Stat5b - signal transducer and activator of transcription 5B Gene

中文名称：信号转导和转录激活因子 5 B

种属: Mus musculus

关于 Stat5b

功能概要

该基因编码的蛋白可启动 DNA 结合转录激活剂活性，RNA 聚合酶 II 特异性； RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性；和蛋白质二聚化活性。参与细胞对生长因子刺激的反应；通过 JAK-STAT 的生长激素受体信号通路；和 RNA 聚合酶 II 对转录的正调控。作用于多个过程的上游或内部，包括动物器官发育；积极调节防御反应；和淋巴细胞活化的正调节。位于细胞质和细胞核中。以多种结构表达，包括大脑；泌尿生殖系统；直觉;淋巴系统腺体；以及肝脏和胆道系统。该基因的人类直向同源基因与免疫失调的生长激素不敏感综合征 1 和免疫失调的生长激素不敏感综合征 2 相关。与人类 STAT5B（信号转导和转录激活因子 5B）直系同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in cellular response to growth factor stimulus; growth hormone receptor signaling pathway via JAK-STAT; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; positive regulation of defense response; and positive regulation of lymphocyte activation. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in growth hormone insensitivity syndrome with immune dysregulation 1 and growth hormone insensitivity syndrome with immune dysregulation 2. Orthologous to human STAT5B (signal transducer and activator of transcription 5B). [provided by Alliance of Genome Resources, Apr 2022]