2. Stem Cell/Wnt JAK/STAT Signaling Apoptosis
  3. STAT Apoptosis
  4. Pomstafib-2

Pomstafib-2 是一种有效的选择性 STAT5b 抑制剂。Pomstafib-2 降低 pSTAT5b 的表达并诱导细胞凋亡 (Apoptosis)。

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Pomstafib-2 Chemical Structure

Pomstafib-2 Chemical Structure

CAS No. : 2332841-83-3

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Pomstafib-2 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pomstafib-2 is a potent and selective STAT5b inhibitor. Pomstafib-2 decreases the expression of pSTAT5b and induces Apoptosis[1][2].

体外研究
(In Vitro)

Pomstafib-2 (compound 8) (0-10 µM; 4 h) decreases the expression of pSTAT5b in a dose-dependent manner in STAT5b-GFP-transfected K562 cells[1].
Pomstafib-2 (0, 10, 20, 40, 60, 80 µM; 48 h) induces apoptosis in a dose-dependent manner in STAT5-dependent K562 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pomstafib-2 相关抗体:

Western Blot Analysis[1]

Cell Line: K562 leukaemia cells
Concentration: 0, 0.3, 1, 3, 10 µM
Incubation Time: 4 h
Result: Decreased the expression of pSTAT5b in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: K562, MDA-MB-231 cells
Concentration: 0, 10, 20, 40, 60, 80 µM
Incubation Time: 48 h
Result: Induced apoptosis in a dose-dependent manner in K562 cells, does not increased the apoptotic rate of STAT5-independent MDA-MB-231 cells.
分子量

1101.03

Formula

C52H66N2O20P2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pomstafib-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomstafib-22332841-83-3Pomstafib2Pomstafib 2STATApoptosisK562MDA-MB-231 cellsapoptosispSTAT5bInhibitorinhibitorinhibit

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