ETV5 - ETS variant transcription factor 5 Gene

中文名称：ETS 变体转录因子 5

种属: Homo sapiens

同用名: ERM

基因 ID: 2119 | 基因类型: protein coding

关于 ETV5

Cytogenetic location: 3q27.2 Genomic coordinates (GRCh38): 3:186,046,314-186,109,089 (from NCBI)

This gene has 14 transcripts (splice variants), 131 orthologues, 28 paralogues and is associated with 62 phenotypes. Broad expression in brain (RPKM 25.8), adrenal (RPKM 22.0) and 23 other tissues.

功能概要

启用 DNA 结合转录激活因子活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 转录调节区序列特异性 DNA 结合活性。参与细胞对氧化应激的反应； RNA 聚合酶 II 对转录的负调控；和 RNA 聚合酶 II 对转录的正调控。位于核质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in cellular response to oxidative stress; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ETV5 基因产物(1)

mRNA	Protein	Name
NM_004454.3	NP_004445.1	ETS translocation variant 5

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: 通过突变表型推断	15857832	GOA
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	19443906	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: 通过突变表型推断	15857832	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17126306	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	19443906	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to oxidative stress	IDA IDA: 通过直接分析推断	19443906	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	17126306	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	15857832	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	19443906	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ETV5 蛋白结构

ETS_PEA3_N

Ets

0
100
200
300
400
510 a.a.

蛋白主名

其他名称

ETS translocation variant 5

ets-related molecule

ETV5 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ETV5	P41161	COP1	Homo sapiens	Q8NHY2	BioID	35140242
种属内	ETV5	P41161	COP1	Homo sapiens	Q8NHY2	Affinity Chrom	35140242
种属内	ETV5	P41161	COP1	Homo sapiens	Q8NHY2	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Acoustic Neuroma

Neurofibromatosis Type 2	Vestibular Schwannoma
Acoustic Neurinoma	Bilateral Acoustic Neurofibromatosis
Nf2	Acoustic Neurilemoma
Cerebellopontine Angle Tumor	Neurofibromatosis Central Type
Neurofibromatosis Type Ii	Vestibular Neurilemmoma
Acoustic Tumor	Neurinoma Of The Acoustic Nerve
Acoustic Neurinoma Bilateral	Acoustic Schwannomas Bilateral
Banf	Central Neurofibromatosis
Familial Acoustic Neuromas	Neurofibromatosis 2
Neurofibromatosis Type 2 Merlin	Schwannoma, Acoustic, Bilateral
Neuroma Acoustic	Neuroma, Acoustic
Familial Acoustic Neuroma	Familial Vestibular Schwannoma
Neurofibromatosis, Central Type	Nf2 - [Neurofibromatosis Type 2]

Charcot-Marie-Tooth Disease, Axonal, Type 2dd

CMT2DD	Charcot-Marie-Tooth Neuropathy, Type 2dd
Charcot-Marie-Tooth Disease Type 2dd	Atp1a1-Related Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Atp1a1-Related Cmt2	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2dd
Charcot-Marie-Tooth Disease 2dd

Lacrimoauriculodentodigital Syndrome

Ladd Syndrome	Levy-Hollister Syndrome
Lacrimo-Auriculo-Dento-Digital Syndrome	LADD
Lacrimoauriculodento-Digital Syndrome	Levy Hollister Syndrome
Lard Syndrome	Lacrimoauriculoradiodental Syndrome
LADDS	Congenital Duodenal Obstruction Due To Malrotation Of Intestine

Renal Hypodysplasia/Aplasia 1

Renal Agenesis	Renal Adysplasia
Renal Aplasia	RHDA1
Hereditary Renal Aplasia	Hra
Hereditary Urogenital Adysplasia	Hypodysplasia/Aplasia, Renal, Type 1
Congenital Absence Of Kidneys Syndrome	Congenital Absence Of Kidney
Aplastic Kidney

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Cakut

Renal Or Urinary Tract Malformation	Congenital Anomalies Of Kidney And Urinary Tract
Congenital Anomaly Of Kidney And Urinary Tract	Congenital Anomalies Of The Kidney And Urinary Tract
Kidney And Urinary Tract, Anomalies, Congenital	Renal Hypodysplasia, Nonsyndromic, 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04568	ETV5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	ETV5	VGNC	VGNC:40499
Rattus norvegicus	ETV5	RGD	RGD:1309590
Mus musculus	ETV5	MGD	MGI:1096867
Felis catus	ETV5	VGNC	VGNC:61985
Macaca mulatta	ETV5	VGNC	VGNC:72443
Bos taurus	ETV5	VGNC	VGNC:28631

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ETV5 - ETS variant transcription factor 5 Gene

关于 ETV5

功能概要

ETV5 基因产物(1)

ETV5 蛋白结构

ETV5 蛋白互作信息

关联疾病

直系同源

热门区域

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ETV5 - ETS variant transcription factor 5 Gene

关于 ETV5

功能概要

ETV5 基因产物(1)

ETV5 蛋白结构

ETV5 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z