2. Gene
  3. Tgfbr1 - transforming growth factor, beta receptor I Gene

Tgfbr1 - transforming growth factor, beta receptor I Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：转化生长因子， β 受体 I

种属: Mus musculus

同用名: ALK5; ESK2; Alk-5; TGFR-1; TbetaRI; TbetaR-I

基因 ID: 21812 | 基因类型: protein coding

关于 Tgfbr1

Chromosome 4: 47,353,222-47,414,931 forward strand.GRCm39:CM000997.3

This gene has 5 transcripts (splice variants), 236 orthologues, 11 paralogues and is associated with 33 phenotypes. Broad expression in CNS E11.5 (RPKM 19.6), placenta adult (RPKM 12.8) and 25 other tissues.

功能概要

该基因编码转化生长因子 β (TGF-β) 受体蛋白家族的成员。这些蛋白质包含 TGF-β 信号转导通路的一个组成部分，该通路将细胞外信号转导为基因表达变化，以调节广泛的细胞反应，包括增殖、迁移、分化和凋亡。该基因的纯合基因敲除小鼠表现出受损的血管生成和胚胎致死率。可变剪接导致多个转录本变体。 [RefSeq 提供，2015 年 8 月]

This gene encodes a member of the transforming growth factor beta (TGF-beta) receptor family of proteins. These proteins comprise one component of the TGF-beta signaling pathway, which transduces extracellular signals into gene expression changes to regulate a wide range of cellular responses, including proliferation, migration, differentiation and Apoptosis. Homozygous knockout mice for this gene exhibit impaired angiogenesis and embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Tgfbr1 基因产物(3)

mRNA Protein Name
NM_001312868.1 NP_001299797.1 TGF-beta receptor type-1 isoform 2 precursor
NM_009370.3 NP_033396.1 TGF-beta receptor type-1 isoform 1 precursor
NM_001312869.1 NP_001299798.1 TGF-beta receptor type-1 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SMAD binding IDA
IDA: 通过直接分析推断
12773577 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12773577 MGI
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
25065622 MGI
enables transforming growth factor beta binding IPI
IPI: 通过物理相互作用推断
17878231 MGI
enables transforming growth factor beta receptor activity IDA
IDA: 通过直接分析推断
15820682 MGI
enables transforming growth factor beta receptor activity IGI
IGI: 通过遗传相互作用推断
17878231 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within angiogenesis IMP
IMP: 通过突变表型推断
11285230 MGI
involved in angiogenesis involved in coronary vascular morphogenesis IMP
IMP: 通过突变表型推断
18718461 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: 通过遗传相互作用推断
16845371 MGI
acts upstream of apoptotic process IMP
IMP: 通过突变表型推断
16806156 MGI
acts upstream of or within artery morphogenesis IMP
IMP: 通过突变表型推断
17078885 MGI
acts upstream of or within blastocyst development IDA
IDA: 通过直接分析推断
9921650 MGI
involved in cellular response to transforming growth factor beta stimulus IDA
IDA: 通过直接分析推断
19494318 MGI
acts upstream of or within collagen fibril organization IMP
IMP: 通过突变表型推断
15993878 MGI
involved in coronary artery morphogenesis IMP
IMP: 通过突变表型推断
18718461 MGI
acts upstream of or within embryo development IMP
IMP: 通过突变表型推断
14729481 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IMP
IMP: 通过突变表型推断
16806156 MGI
acts upstream of or within endothelial cell migration IMP
IMP: 通过突变表型推断
11285230 MGI
acts upstream of endothelial cell proliferation IGI
IGI: 通过遗传相互作用推断
21832243 MGI
involved in epicardium morphogenesis IMP
IMP: 通过突变表型推断
18718461 MGI
acts upstream of filopodium assembly IMP
IMP: 通过突变表型推断
16806156 MGI
acts upstream of or within germ cell migration IMP
IMP: 通过突变表型推断
15993878 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
17078885 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
11285230 MGI
acts upstream of or within kidney development IGI
IGI: 通过遗传相互作用推断
16845371 MGI
acts upstream of or within lens development in camera-type eye IMP
IMP: 通过突变表型推断
11641223 MGI
acts upstream of or within male gonad development IMP
IMP: 通过突变表型推断
23342175 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
16806156 MGI
involved in negative regulation of chondrocyte differentiation IMP
IMP: 通过突变表型推断
19494318 MGI
acts upstream of or within negative regulation of endothelial cell proliferation IGI
IGI: 通过遗传相互作用推断
21832243 MGI
acts upstream of or within neuron fate commitment IMP
IMP: 通过突变表型推断
15744664 MGI
acts upstream of or within parathyroid gland development IMP
IMP: 通过突变表型推断
17078885 MGI
acts upstream of or within pharyngeal system development IMP
IMP: 通过突变表型推断
17078885 MGI
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
24835278 MGI
involved in positive regulation of epithelial to mesenchymal transition IGI
IGI: 通过遗传相互作用推断
18718461 MGI
involved in positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation IMP
IMP: 通过突变表型推断
18718461 MGI
acts upstream of or within positive regulation of filopodium assembly IMP
IMP: 通过突变表型推断
16806156 MGI
involved in positive regulation of stress fiber assembly IGI
IGI: 通过遗传相互作用推断
18718461 MGI
involved in positive regulation of tight junction disassembly IGI
IGI: 通过遗传相互作用推断
18718461 MGI
acts upstream of or within post-embryonic development IMP
IMP: 通过突变表型推断
16806156 MGI
NOT involved in proepicardium development IMP
IMP: 通过突变表型推断
18718461 MGI
involved in regulation of cardiac muscle cell proliferation IMP
IMP: 通过突变表型推断
18718461 MGI
acts upstream of or within regulation of gene expression IMP
IMP: 通过突变表型推断
16806156 MGI
acts upstream of or within regulation of protein binding IMP
IMP: 通过突变表型推断
16601693 MGI
involved in response to cholesterol IDA
IDA: 通过直接分析推断
17878231 MGI
acts upstream of or within roof of mouth development IGI
IGI: 通过遗传相互作用推断
16845371 MGI
acts upstream of or within roof of mouth development IMP
IMP: 通过突变表型推断
16806156 MGI
acts upstream of or within skeletal system development IGI
IGI: 通过遗传相互作用推断
16845371 MGI
acts upstream of or within skeletal system morphogenesis IGI
IGI: 通过遗传相互作用推断
16845371 MGI
acts upstream of or within thymus development IMP
IMP: 通过突变表型推断
17078885 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
14580334 MGI
involved in transforming growth factor beta receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
18718461 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
11285230 MGI
involved in ventricular compact myocardium morphogenesis IMP
IMP: 通过突变表型推断
18718461 MGI
involved in ventricular septum morphogenesis IMP
IMP: 通过突变表型推断
18718461 MGI
involved in ventricular trabecula myocardium morphogenesis IMP
IMP: 通过突变表型推断
18718461 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endosome IDA
IDA: 通过直接分析推断
21266196 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Tgfbr1 蛋白结构

Activin_recp

Activin_recp: pfam01064 (29 - 105)

TGF_beta_GS

TGF_beta_GS: pfam08515 (175 - 202)

STKc_TGFbR1_ACVR1b_ACVR1c

STKc_TGFbR1_ACVR1b_ACVR1c: cd14143 (208 - 495)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 503 a.a.
蛋白主名 其他名称

TGF-beta receptor type-1

TGF-beta receptor type I

transforming growth factor-beta receptor type I

重组 Tgfbr1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72454 TGFBR1/ALK-5 Protein, Mouse (HEK293, Fc) Q64729 (L30-E125) ≥95%

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-136244 PF-06952229 Inhibitor 99.92% Phase 1
Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-123900 AZ12799734 Inhibitor 98.07% 否
HY-122856 AZ12601011 Inhibitor 99.88% 否
HY-129171 TGFBR1-IN-1 Inhibitor / 否
HY-RS14444 TGFBR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14445 Tgfbr1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14446 TGFBR1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tgfbr1 NCBI NCBI:7046
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