2. Gene
  3. Tlr6 - toll-like receptor 6 Gene

Tlr6 - toll-like receptor 6 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：Toll 样受体 6

种属: Mus musculus

基因 ID: 21899 | 基因类型: protein coding

关于 Tlr6

Chromosome 5: 65,109,374-65,117,440 reverse strand.GRCm39:CM000998.3

This gene has 3 transcripts (splice variants), 190 orthologues, 23 paralogues and is associated with 9 phenotypes. Broad expression in spleen adult (RPKM 3.6), colon adult (RPKM 1.8) and 17 other tissues.

功能概要

该基因编码的蛋白可启动二酰基脂肽结合活性。参与多个过程，包括生物合成过程的正向调节；调节细胞因子的产生；和 toll 样受体信号通路。 Toll 样受体 2-Toll 样受体 6 蛋白复合物的一部分。在大脑皮层和端脑中表达。该基因的人类直系同源物与曲霉病有关；哮喘;感染性心内膜炎;鼻炎;和肺结核。与人类 TLR6（toll 样受体 6）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables diacyl Lipopeptide binding activity. Involved in several processes, including positive regulation of biosynthetic process; regulation of cytokine production; and Toll-like Receptor signaling pathway. Part of Toll-like Receptor 2-Toll-like receptor 6 protein complex. Is expressed in cerebral cortex and telencephalon. Human ortholog(s) of this gene implicated in aspergillosis; asthma; infective endocarditis; rhinitis; and tuberculosis. Orthologous to human TLR6 (toll like receptor 6). [provided by Alliance of Genome Resources, Apr 2022]

Tlr6 基因产物(6)

mRNA Protein Name
NM_001359180.2 NP_001346109.2 toll-like receptor 6 precursor
NM_001384171.1 NP_001371100.1 toll-like receptor 6 precursor
NM_011604.5 NP_035734.4 toll-like receptor 6 precursor
NM_001359180.2 NP_001346109.2 toll-like receptor 6 precursor
NM_001384171.1 NP_001371100.1 toll-like receptor 6 precursor
NM_011604.5 NP_035734.4 toll-like receptor 6 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables diacyl lipopeptide binding IDA
IDA: 通过直接分析推断
19931471 MGI
enables lipopeptide binding IMP
IMP: 通过突变表型推断
11431423 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
19931471 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in MyD88-dependent toll-like receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
20037584 MGI
involved in TRIF-dependent toll-like receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
20037584 MGI
involved in cellular response to oxidised low-density lipoprotein particle stimulus IGI
IGI: 通过遗传相互作用推断
20037584 MGI
involved in negative regulation of tumor necrosis factor production IGI
IGI: 通过遗传相互作用推断
22198949 MGI
involved in positive regulation of NLRP3 inflammasome complex assembly IDA
IDA: 通过直接分析推断
23812099 MGI
involved in positive regulation of cytokine production involved in inflammatory response IGI
IGI: 通过遗传相互作用推断
20037584 MGI
involved in positive regulation of extrinsic apoptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
20037584 MGI
involved in positive regulation of gene expression IGI
IGI: 通过遗传相互作用推断
20037584 MGI
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
20037584 MGI
involved in positive regulation of inflammatory response IGI
IGI: 通过遗传相互作用推断
20037584 MGI
involved in positive regulation of interleukin-1 beta production IDA
IDA: 通过直接分析推断
23812099 MGI
involved in positive regulation of macrophage activation IGI
IGI: 通过遗传相互作用推断
20037584 MGI
involved in positive regulation of nitric oxide biosynthetic process IGI
IGI: 通过遗传相互作用推断
20037584 MGI
involved in positive regulation of reactive oxygen species biosynthetic process IMP
IMP: 通过突变表型推断
20037584 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Toll-like receptor 2-Toll-like receptor 6 protein complex IDA
IDA: 通过直接分析推断
19931471 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Tlr6 蛋白结构

LRR_RI

LRR_RI: sd00033 (35 - 52)

PLN00113

PLN00113: cl33413 (38 - 528)

LRR_1

LRR_1: sd00031 (53 - 76)

LRR_8

LRR_8: pfam13855 (75 - 132)

LRR_1

LRR_1: sd00031 (77 - 100)

LRR_1

LRR_1: sd00031 (101 - 121)

LRR_1

LRR_1: sd00031 (122 - 146)

LRR_RI

LRR_RI: sd00033 (172 - 194)

LRR_RI

LRR_RI: sd00033 (195 - 218)

LRR_RI

LRR_RI: sd00033 (278 - 302)

LRR_RI

LRR_RI: sd00033 (303 - 331)

LRR_RI

LRR_RI: sd00033 (332 - 353)

LRR_RI

LRR_RI: sd00033 (378 - 403)

LRR_RI

LRR_RI: sd00033 (404 - 428)

LRR_RI

LRR_RI: sd00033 (429 - 450)

LRR_RI

LRR_RI: sd00033 (451 - 473)

LRR_RI

LRR_RI: sd00033 (474 - 496)

LRR_RI

LRR_RI: sd00033 (498 - 519)

LRRCT

LRRCT: smart00082 (528 - 582)

TIR

TIR: smart00255 (640 - 779)

  • 0
  • 200
  • 400
  • 600
  • 795 a.a.
蛋白主名 其他名称

toll-like receptor 6

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P2036A FSL-1 TFA Agonist 99.65% 否
HY-P2036 FSL-1 Agonist / 否
HY-P10586 Macrophage-activating lipopeptide 2 Activator / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tlr6 NCBI NCBI:10333
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