FAT1 - FAT atypical cadherin 1 Gene

中文名称：FAT 非典型钙粘蛋白 1

种属: Homo sapiens

同用名: FAT; ME5; CDHF7; CDHR8; hFat1

基因 ID: 2195 | 基因类型: protein coding

关于 FAT1

Cytogenetic location: 4q35.2 Genomic coordinates (GRCh38): 4:186,587,794-186,726,696 (from NCBI)

This gene has 11 transcripts (splice variants), 241 orthologues, 6 paralogues and is associated with 162 phenotypes. Broad expression in colon (RPKM 17.7), kidney (RPKM 13.3) and 21 other tissues.

功能概要

该基因是果蝇脂肪基因的直向同源基因，该基因编码的肿瘤抑制因子对于控制果蝇发育过程中的细胞增殖至关重要。该基因产物是钙粘蛋白超家族的成员，钙粘蛋白超家族是一组完整的膜蛋白，其特征在于存在钙粘蛋白型重复序列。除了含有 34 个串联钙粘蛋白型重复序列外，该基因产物还有 5 个表皮生长因子 (EGF) 样重复序列和 1 个层粘连蛋白 AG 结构域。该基因在许多胎儿上皮细胞中以高水平表达。其产物可能作为粘附分子和/或信号受体发挥作用，并且可能在发育过程和细胞通讯中起重要作用。存在源自替代剪接和/或替代启动子使用的转录变体，但尚未对其进行充分描述。[RefSeq 提供，2008 年 7 月]

This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]

FAT1 基因产物(1)

mRNA	Protein	Name
NM_005245.4	NP_005236.2	protocadherin Fat 1 precursor

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16979624	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell-cell junction	IDA IDA: 通过直接分析推断	15148305	GOA
located in nucleus	IDA IDA: 通过直接分析推断	15922730	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	15922730	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	15922730	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FAT1 蛋白结构

Cadherin

Laminin_G_2

EGF

EGF_CA

0
800
1600
2400
3200
4000
4588 a.a.

蛋白主名

其他名称

protocadherin Fat 1

FAT tumor suppressor 1

FAT1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FAT1	Q14517	ENAH	Homo sapiens	Q8N8S7	ELISA	16979624
种属间	FAT1	Q14517	Homer3	Mus musculus	Q99JP6	Pull Down	16979624
种属内	FAT1	Q14517	HOMER3	Homo sapiens	Q9NSC5	ELISA	16979624

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Myasthenic Syndrome, Congenital, 12

Congenital Myasthenic Syndrome 12	CMS12
Myasthenic Syndrome, Congenital, With Tubular Aggregates 1	Cmsta1
Myasthenia, Congenital, 12, With Tubular Aggregates	Congenital Myasthenia 12 With Tubular Aggregates
Limb-Girdle Myasthenia With Tubular Aggregates	Myasthenia, Congenital, With Tubular Aggregates 1
Myasthenic Syndrome, Congenital, With Tubular Aggregates, 1

Nephrotic Syndrome, Type 1

Finnish Congenital Nephrosis	NPHS1
Cnf	Finnish Congenital Nephrotic Syndrome
Nephrotic Syndrome Type 1	Nephrosis, Congenital
Congenital Nephrotic Syndrome	Nephrotic Syndrome, Congenital
Congenital Nephrotic Syndrome Finnish Type	Congenital Nephrotic Syndrome 1
Nephrosis 1, Congenital, Finnish Type	Congenital Nephrotic Syndrome, Finnish Type
Nephrotic Syndrome 1	Congenital Nephrotic Syndrome Of The Finnish Type

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome	Ns - [Nephrotic Syndrome]
Nephrosis Syndrome	Nephrosis Nos
Glomerular Lesion Nephrosis

Squamous Cell Carcinoma

Epidermoid Carcinoma	Squamous Cell Cancer
Carcinoma, Squamous Cell	Squamous Cell Skin Cancer
Malignant Squamous Cell Tumor	Squamous Carcinoma
Squamous Cell Epithelioma	Carcinoma Squamous Cell
Neoplasms, Squamous Cell	Squamous Cell Carcinoma - Category
Malignant Squamous Cell Neoplasm	Squamous Cell Carcinoma Of Skin

Plasma Cell Neoplasm

Plasma Cell Dyscrasia	Paraproteinemias
Plasma Cell Tumour	Plasmacytic Tumor
Multiple Myeloma	Plasmacytoma
Plasma Cell Tumours	Plasma Cells Dyscrasia

Endocervical Adenocarcinoma

Endocervical Carcinoma

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Spinocerebellar Ataxia 45

SCA45

Spinocerebellar Ataxia Type 45

Cervical Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Cervix Uteri

Squamous Cell Carcinoma Of Cervix

Gastric Fundus Cancer

Gastric Fundus Carcinoma	Ca Fundus - Stomach
Malignant Neoplasm Of Fundus Of Stomach	Malignant Tumor Of Fundus Of Stomach
Cancer Of Fundus Of Stomach	Carcinoma Of Fundus Of Stomach
Malignant Neoplasm Of Gastric Fundus

Uterine Corpus Endometrial Carcinoma

Lung Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Lung	Squamous Cell Lung Carcinoma
Epidermoid Cell Carcinoma Of The Lung	Squamous Cell Lung Cancer

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Van Maldergem Syndrome

Van Maldergem Wetzburger Verloes Syndrome	Cerebro-Facio-Articular Syndrome
Cerebro-Facio-Articular Syndrome Of Van Maldergem	Cerebrofacioarticular Syndrome
Cerebro Facio Articular Syndrome	Van Maldergem-Wetzburger-Verloes Syndrome

Bladder Urothelial Carcinoma

Bladder Transitional Cell Carcinoma	Transitional Cell Carcinoma Of Bladder
Transitional Cell Carcinoma Of The Bladder	Urinary Bladder Urothelial Carcinoma
Urothelial Bladder Carcinoma	Carcinoma Transitional Cell Bladder
Tcc - [Transitional Cell Carcinoma] Of Bladder

Facioscapulohumeral Muscular Dystrophy 1

Facioscapulohumeral Muscular Dystrophy	Fshd
Landouzy-Dejerine Muscular Dystrophy	Muscular Dystrophy, Facioscapulohumeral
FSHD1	Fshd1a
Muscular Dystrophy, Facioscapulohumeral, Type 1a	Facioscapulohumeral Muscular Dystrophy Type 1a
Fsh Muscular Dystrophy	Facioscapulohumeral Muscular Dystrophy 1a
Facioscapulohumeral Atrophy	Facioscapulohumeral Myopathy
Muscular Dystrophy, Facioscapulohumeral, Type 1	Facioscapulohumeral Muscular Dystrophy Type 1
Landouzy Dejerine Muscular Dystrophy	Muscular Dystrophy, Landouzy-Dejerine
Fshmd1a	Facio-Scapulo-Humeral Dystrophy
Facioscapulohumeral Type Progressive Muscular Dystrophy	Facioscapuloperoneal Muscular Dystrophy
Facioscapulohumeral Dystrophy	Fsh Dystrophy
Landouzy-Dejerine Dystrophy	Landouzy-Dejerine Myopathy
Fmd	Facioscapulohumeral Muscular Dystrophy-1a
Muscular Dystrophy Facioscapulohumeral	Dystrophy, Muscular, Facioscapulohumeral
Dystrophy, Muscular, Facioscapulohumeral, Type 1	Landouzy-Dejerine Disease
Landouzy-Déjerine Atrophy	Facioscapulohumeral Muscle Dystrophy
Fmd - [Facioscapulohumeral Muscular Dystrophy]	Fsh - [Facioscapulohumeral Muscular Dystrophy]
Fshd - [Facioscapulohumeral Muscular Dystrophy]	Landouzy-Déjerine Dystrophy Or Facioscapulohumeral Atrophy
Landouzy-Déjérine Muscular Dystrophy

Spinocerebellar Ataxia, Autosomal Recessive 17

Autosomal Recessive Spinocerebellar Ataxia 17	SCAR17
Autosomal Recessive Cerebellar Ataxia Due To Cwf19l1 Deficiency	Spinocerebellar Ataxia Autosomal Recessive Type 17
Spinocerebellar Ataxia, Autosomal Recessive, 17	Ataxia, Spinocerebellar, Autosomal Recessive, Type 17

Anus Basaloid Carcinoma

Basaloid Carcinoma Of The Anus

Anal Basaloid Carcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-115319	CP-24879 hydrochloride		98.00%	否
HY-124141	Myristelaidic acid		≥98.0%	否
HY-135297	Mono-and diglycerides		97.50%	否
HY-B1567	Bromocyclen		/	否
HY-RS04760	FAT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W753983	Pyruvic acid-13C3		/	否
HY-168386	1,2-Dipalmitoyl-3-Myristoyl-rac-glycerol		/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	FAT1	MGD	MGI:109168
Canis familiaris	FAT1	VGNC	VGNC:40742
Felis catus	FAT1	VGNC	VGNC:62157
Rattus norvegicus	FAT1	RGD	RGD:621254
Bos taurus	FAT1	VGNC	VGNC:52771
Macaca mulatta	FAT1	VGNC	VGNC:72617
Others	FAT1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FAT1 - FAT atypical cadherin 1 Gene

关于 FAT1

功能概要

FAT1 基因产物(1)

FAT1 蛋白结构

FAT1 蛋白互作信息

关联疾病

直系同源

热门区域

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FAT1 - FAT atypical cadherin 1 Gene

关于 FAT1

功能概要

FAT1 基因产物(1)

FAT1 蛋白结构

FAT1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z