ENAH - ENAH actin regulator Gene

中文名称：ENAH 肌动蛋白调节因子

种属: Homo sapiens

同用名: ENA; MENA; NDPP1

基因 ID: 55740 | 基因类型: protein coding

关于 ENAH

Cytogenetic location: 1q42.12 Genomic coordinates (GRCh38): 1:225,486,829-225,653,878 (from NCBI)

This gene has 10 transcripts (splice variants), 234 orthologues and 5 paralogues. Ubiquitous expression in gall bladder (RPKM 8.3), prostate (RPKM 7.8) and 24 other tissues.

功能概要

该基因编码启用/血管扩张剂刺激的磷蛋白的成员。该基因家族的成员参与基于肌动蛋白的运动。这种蛋白质参与调节肌动蛋白丝的组装并调节细胞粘附和运动。该基因的交替剪接变体与某些组织中的肿瘤侵袭性相关，这些变体可作为预后标志物。在 3 号染色体上发现了该基因的假基因。[RefSeq 提供，2016 年 9 月]

This gene encodes a member of the enabled/ vasodilator-stimulated phosphoprotein. Members of this gene family are involved in actin-based motility. This protein is involved in regulating the assembly of actin filaments and modulates cell adhesion and motility. Alternate splice variants of this gene have been correlated with tumor invasiveness in certain tissues and these variants may serve as prognostic markers. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2016]

ENAH 基因产物(5)

mRNA	Protein	Name
NM_001008493.3	NP_001008493.1	protein enabled homolog isoform a
NM_001377481.1	NP_001364410.1	protein enabled homolog isoform c
NM_001377482.1	NP_001364411.1	protein enabled homolog isoform d
NM_001377483.1	NP_001364412.1	protein enabled homolog isoform e
NM_018212.6	NP_060682.2	protein enabled homolog isoform b

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables WW domain binding	IPI IPI: 通过物理相互作用推断	17686488	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10801818	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ENAH 蛋白结构

WH1

VASP_tetra

0
100
200
300
400
500
591 a.a.

蛋白主名

其他名称

protein enabled homolog

Mena delta 11a

ENAH 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	ENAH	Q8N8S7	FAT1	Homo sapiens	Q14517	ELISA	16979624
Intra	ENAH	Q8N8S7	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950
Intra	ENAH	Q8N8S7	TERF2IP	Homo sapiens	Q9NYB0	BiFC	21044950

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Gastric Papillary Adenocarcinoma

Papillary Adenocarcinoma Of Stomach

Retinitis Pigmentosa 54

RP54	Retinitis Pigmentosa, Type 54

Gastric Tubular Adenocarcinoma

Tubular Adenocarcinoma Of Stomach

Valproate Embryopathy

Fetal Valproate Syndrome	Fetal Valproic Acid Syndrome
Fvs	Valproic Acid Embryopathy
Fetal Valproate Spectrum Disorder	Valproate Embryopathy, Susceptibility To
Foetal Valproate Syndrome	Foetal Valproic Acid Syndrome
Susceptibility To Valproate Embryopathy	Valproic Acid Antenatal Infection

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04367	ENAH Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	ENAH	VGNC	VGNC:61855
Canis familiaris	ENAH	VGNC	VGNC:40357
Rattus norvegicus	ENAH	RGD	RGD:1307666
Macaca mulatta	ENAH	VGNC	VGNC:99903
Bos taurus	ENAH	VGNC	VGNC:59333
Mus musculus	ENAH	MGD	MGI:108360

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ENAH - ENAH actin regulator Gene

关于 ENAH

功能概要

ENAH 基因产物(5)

ENAH 蛋白结构

ENAH 蛋白互作信息

关联疾病

直系同源

热门区域

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ENAH - ENAH actin regulator Gene

关于 ENAH

功能概要

ENAH 基因产物(5)

ENAH 蛋白结构

ENAH 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z