Tyms - thymidylate synthase Gene

中文名称：胸苷酸合酶

种属: Mus musculus

同用名: Ts

关于 Tyms

功能概要

该基因编码一种酶，该酶使用 5,10-亚甲基四氢叶酸作为辅因子催化脱氧尿苷酸甲基化为脱氧胸苷酸。该功能可维持对 DNA 复制和修复至关重要的胸苷 5-磷酸一磷酸浓度。编码的酶是癌症化学治疗剂的靶标。该基因的大部分转录本缺少 3' UTR（PMID：3022294、3444407）。与基因组中发现的 UAG 和更长的转录本相比，这些转录本中的终止密码子是 UAA，因为 polyA 位点位于终止密码子内（PMID：3444407、2157203）。已在 10 号染色体上鉴定出一个相关的假基因。[RefSeq 提供，2010 年 3 月]

This gene encodes an Enzyme that catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate as a cofactor. This function maintains the thymidine-5-prime monophosphate concentration critical for DNA replication and repair. The encoded Enzyme is a target for Cancer chemotherapeutic agents. The majority of transcripts for this gene lack a 3' UTR (PMID: 3022294, 3444407). The stop codon in these transcripts is UAA, compared to the UAG found in the genome and longer transcripts, as the polyA site is located within the stop codon (PMID: 3444407, 2157203). A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Mar 2010]