1. Gene
  2. ADGRG3 - adhesion G protein-coupled receptor G3 Gene

ADGRG3 - adhesion G protein-coupled receptor G3 Gene

中文名称:粘附 G 蛋白偶联受体 G3

种属: Homo sapiens

同用名: PB99; GPR97; PGR26

基因 ID: 222487 | 基因类型: protein coding

关于 ADGRG3

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:57,665,629-57,689,378 (from NCBI)

This gene has 7 transcripts (splice variants), 271 orthologues and 42 paralogues. Biased expression in bone marrow (RPKM 59.0), appendix (RPKM 9.5) and 1 other tissue.

功能概要

预计可启用 G 蛋白偶联受体活性。参与 G 蛋白偶联受体信号通路和细胞迁移的调节。位于质膜。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and regulation of cell migration. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ADGRG3 基因产物(2)

mRNA Protein Name
NM_001308360.2 NP_001295289.1 adhesion G protein-coupled receptor G3 isoform 2
NM_170776.5 NP_740746.4 adhesion G protein-coupled receptor G3 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
22575658 GOA
involved in regulation of cell migration IMP
IMP: 通过突变表型推断
24178298 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IMP
IMP: 通过突变表型推断
22575658 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ADGRG3 蛋白结构

GPS

GPS: GPCR proteolysis site, GPS, motif (212 - 255)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (268 - 517)

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  • 500
  • 549 a.a.
蛋白主名 其他名称

adhesion G protein-coupled receptor G3

G protein-coupled receptor 97

ADGRG3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ADGRG3 Q86Y34 TEX264 Homo sapiens Q9Y6I9
Validated Y2H
32296183
Intra ADGRG3 Q86Y34 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra ADGRG3 Q86Y34 C4orf3 Homo sapiens Q8WVX3-2
Validated Y2H
32296183
Intra ADGRG3 Q86Y34 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Intra ADGRG3 Q86Y34 ATP6V0B Homo sapiens Q99437
Validated Y2H
32296183
Intra ADGRG3 Q86Y34 GIMAP5 Homo sapiens Q96F15
Validated Y2H
32296183
Intra ADGRG3 Q86Y34 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Vibratory Urticaria

Vibratory Angioedema

Dermodistortive Urticaria

VBU

Ddu

Angioedema, Vibratory

Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria

BFPP

Cerebellar Ataxia With Neuronal Migration Defect

Congenital Epulis

Gingival Neoplasms

Congenital Epulides

Congenital Gingival Cell Tumor

Congenital Granular Cell Tumor

Neumann Tumor

Epulis

Epulides

Gingival Polyp

Polyp Of Gum

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ADGRG3 RGD RGD:1305674
Macaca mulatta ADGRG3 VGNC VGNC:69606
Canis familiaris ADGRG3 VGNC VGNC:37645
Mus musculus ADGRG3 MGD MGI:1859670
Bos taurus ADGRG3 VGNC VGNC:25667
Felis catus ADGRG3 VGNC VGNC:59635