FGB - fibrinogen beta chain Gene

中文名称：纤维蛋白原β链

种属: Homo sapiens

同用名: HEL-S-78p

基因 ID: 2244 | 基因类型: protein coding

关于 FGB

Cytogenetic location: 4q31.3 Genomic coordinates (GRCh38): 4:154,562,980-154,572,807 (from NCBI)

This gene has 7 transcripts (splice variants), 198 orthologues, 25 paralogues and is associated with 6 phenotypes. Restricted expression toward liver (RPKM 2456.5).

功能概要

该基因编码的蛋白质是纤维蛋白原的β成分，纤维蛋白原是一种由三对不同的多肽链组成的血源性糖蛋白。血管损伤后，纤维蛋白原被凝血酶裂解形成纤维蛋白，它是血块中最丰富的成分。此外，纤维蛋白原和纤维蛋白的各种裂解产物调节细胞粘附和扩散，表现出血管收缩和趋化活性，并且是多种细胞类型的有丝分裂原。纤维蛋白原在止血和抗菌宿主防御中起着关键作用。该基因的突变导致多种疾病，包括无纤维蛋白原血症、异常纤维蛋白原血症、低异常纤维蛋白原血症和血栓形成倾向。[RefSeq 提供，2020 年 8 月]

The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by Thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Fibrinogen serves key roles in hemostasis and antimicrobial host defense. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq, Aug 2020]

FGB 基因产物(9)

mRNA	Protein	Name
NM_001184741.1	NP_001171670.1	fibrinogen beta chain isoform 2 preproprotein
NM_001382759.1	NP_001369688.1	fibrinogen beta chain isoform 3 preproprotein
NM_001382760.1	NP_001369689.1	fibrinogen beta chain isoform 4 preproprotein
NM_001382761.1	NP_001369690.1	fibrinogen beta chain isoform 5 preproprotein
NM_001382762.1	NP_001369691.1	fibrinogen beta chain isoform 6 preproprotein
NM_001382763.1	NP_001369692.1	fibrinogen beta chain isoform 7 preproprotein
NM_001382764.1	NP_001369693.1	fibrinogen beta chain isoform 8 preproprotein
NM_001382765.1	NP_001369694.1	fibrinogen beta chain isoform 9 preproprotein
NM_005141.5	NP_005132.2	fibrinogen beta chain isoform 1 preproprotein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
contributes to cell adhesion molecule binding	IDA IDA: 通过直接分析推断	9182580	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12706644	GOA
enables protein-folding chaperone binding	IPI IPI: 通过物理相互作用推断	19996109	GOA
contributes to signaling receptor binding	IDA IDA: 通过直接分析推断	10903502	GOA
enables structural molecule activity	IDA IDA: 通过直接分析推断	8910396	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in blood coagulation, fibrin clot formation	IDA IDA: 通过直接分析推断	16846481	GOA
involved in cell-matrix adhesion	IDA IDA: 通过直接分析推断	10903502	GOA
involved in fibrinolysis	IDA IDA: 通过直接分析推断	16846481	GOA
involved in induction of bacterial agglutination	IDA IDA: 通过直接分析推断	24367264	GOA
involved in negative regulation of endothelial cell apoptotic process	IDA IDA: 通过直接分析推断	10903502	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA IDA: 通过直接分析推断	10903502	GOA
involved in plasminogen activation	IDA IDA: 通过直接分析推断	16846481	GOA
involved in platelet aggregation	IDA IDA: 通过直接分析推断	6281794	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: 通过直接分析推断	10903502	GOA
involved in positive regulation of exocytosis	IDA IDA: 通过直接分析推断	19193866	GOA
involved in positive regulation of heterotypic cell-cell adhesion	IDA IDA: 通过直接分析推断	8100742	GOA
involved in positive regulation of peptide hormone secretion	IDA IDA: 通过直接分析推断	19193866	GOA
involved in positive regulation of protein secretion	IDA IDA: 通过直接分析推断	19193866	GOA
involved in positive regulation of vasoconstriction	IDA IDA: 通过直接分析推断	15739255	GOA
involved in protein polymerization	IDA IDA: 通过直接分析推断	12706644	GOA
involved in protein-containing complex assembly	IDA IDA: 通过直接分析推断	8910396	GOA
involved in response to calcium ion	IDA IDA: 通过直接分析推断	6777381	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell surface	IDA IDA: 通过直接分析推断	6777381	GOA
located in external side of plasma membrane	IDA IDA: 通过直接分析推断	6777381	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	6777381	GOA
part of fibrinogen complex	IDA IDA: 通过直接分析推断	6688356	GOA
located in platelet alpha granule	IDA IDA: 通过直接分析推断	6777381	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FGB 蛋白结构

Fib_alpha

Fibrinogen_C

0
100
200
300
400
491 a.a.

蛋白主名

其他名称

fibrinogen beta chain

beta-fibrinogen

FGB 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	FGB	P02675	P27958-PRO_0000037566	Hepatitis C virus	P27958-PRO_0000037566	BiFC	20162731

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Dysfibrinogenemia, Congenital

Dysfibrinogenemia	Hypodysfibrinogenemia
Familial Dysfibrinogenemia	Familial Hypodysfibrinogenemia
Hypodysfibrinogenemia, Congenital	Dysfibrinogenemia, Familial
Congenital Dysfibrinogenemia	DYSFIBRIN

Afibrinogenemia, Congenital

Congenital Afibrinogenemia	Afibrinogenemia
Factor I Deficiency	Familial Afibrinogenemia
Hypofibrinogenemia, Congenital	Fibrinogen Deficiency
Afibrinogenemia Congenital	CAFBN
Congenital Hypofibrinogenemia	Hypofibrinogenemia
Complement Factor I Deficiency

Hypofibrinogenemia, Familial

Familial Hypofibrinogenemia

Thrombosis

Thrombosis Of Blood Vessel

Pulmonary Embolism

Pulmonary Artery Embolism	Pulmonary Embolus
Pulmonary Emboli

Budd-Chiari Syndrome

Hepatic Vein Thrombosis	Chiari Syndrome
BDCHS	Membranous Obstruction Of The Inferior Vena Cava
Budd-Chiari Syndrome, Somatic	Movc
Budd-Chiari Syndrome, Susceptibility To, Somatic	Budd-Chiari Syndrome, Susceptibility To
Membranous Obstruction Of Inferior Vena Cava	Hepatic Vein Block
Obstruction Of Hepatic Veins	Hepatic Vein Obstruction
Hepatic Venous Block

Thrombophilia

Hypercoagulability State

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Lateral Medullary Syndrome

Posterior Inferior Cerebellar Artery Syndrome	Wallenberg Syndrome
Vertebral Artery Syndrome	Wallenberg'S Syndrome
Pica Syndrome

Familial Hypercholesterolemia

Hyperlipoproteinemia Type Iia	Familial Hyperbetalipoproteinaemia
Familial Hypercholesteremia	Fredrickson Type Iia Hyperlipoproteinemia
Fredrickson Type Iia Lipidaemia	Hyperbetalipoproteinemia
Type Ii Hyperlipidemia	Familial Hypercholesterolæmia
Familial Hypercholesterolaemia	Fh
Hypercholesterolemia Familial	Hyperlipoproteinemia Type Ii
Hypercholesterolemia, Familial

Vascular Disease

Vascular Diseases	Aneurysm
Spinal Cord Ischemia	Vascular Anomaly
Spinal Cord Vascular Diseases	Vascular Tissue Disease

Alopecia-Mental Retardation Syndrome 1

APMR1	Alopecia-Intellectual Disability Syndrome 1
Amr Syndrome	Alopecia-Intellectual Disability Syndrome
Amr Syndrome 1	Alopecia With Severe Intellectual Deficit
Apmr	Alopecia Intellectual Disbility Syndrome 1
Perniola-Krajewska-Carnevale Syndrome	Alopecia - Intellectual Disability Syndrome
Alopecia With Mental Retardation Syndrome 1	Perniola Krajewska Carnevale Syndrome

Cerebral Palsy

Infantile Cerebral Palsy	Mixed Cerebral Palsy
Palsy Cerebral	Palsy, Cerebral
Cerebral Palsy, Mixed

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04879	FGB Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	FGB	MGD	MGI:99501
Canis familiaris	FGB	VGNC	VGNC:54207
Rattus norvegicus	FGB	RGD	RGD:2604
Felis catus	FGB	VGNC	VGNC:62238
Macaca mulatta	FGB	VGNC	VGNC:72641
Bos taurus	FGB	VGNC	VGNC:28963

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FGB - fibrinogen beta chain Gene

关于 FGB

功能概要

FGB 基因产物(9)

FGB 蛋白结构

FGB 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

FGB - fibrinogen beta chain Gene

关于 FGB

功能概要

FGB 基因产物(9)

FGB 蛋白结构

FGB 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z