FGR - FGR proto-oncogene, Src family tyrosine kinase Gene

中文名称：FGR 原癌基因，Src 家族酪氨酸激酶

种属: Homo sapiens

同用名: SRC2; c-fgr; c-src2; p55-Fgr; p58-Fgr; p55c-fgr; p58c-fgr

基因 ID: 2268 | 基因类型: protein coding

关于 FGR

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:27,612,064-27,635,185 (from NCBI)

This gene has 7 transcripts (splice variants), 189 orthologues and 32 paralogues. Biased expression in bone marrow (RPKM 57.8), spleen (RPKM 29.9) and 6 other tissues.

功能概要

该基因是蛋白酪氨酸激酶 (PTK) Src 家族的成员。编码的蛋白质包含用于豆蔻酰化和棕榈酰化的 N 末端位点、PTK 结构域以及 SH2 和 SH3 结构域，它们分别参与介导与含磷酸酪氨酸和富含脯氨酸的基序的蛋白质-蛋白质相互作用。该蛋白质定位于质膜褶皱处，并作为由 beta-2 整合素信号转导通路触发的细胞迁移和粘附的负调节剂发挥作用。感染 Epstein-Barr 病毒会导致该基因的过度表达。已经鉴定出编码相同蛋白质的多个可变剪接变体。[RefSeq 提供，2008 年 7 月]

This gene is a member of the Src family of Protein Tyrosine Kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 Integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

FGR 基因产物(3)

mRNA	Protein	Name
NM_001042729.2	NP_001036194.1	tyrosine-protein kinase Fgr
NM_001042747.2	NP_001036212.1	tyrosine-protein kinase Fgr
NM_005248.3	NP_005239.1	tyrosine-protein kinase Fgr

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables Fc-gamma receptor I complex binding	IDA IDA: 通过直接分析推断	8327512	GOA
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: 通过直接分析推断	8327512	GOA
enables phosphotyrosine residue binding	IPI IPI: 通过物理相互作用推断	20624904	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16273093	GOA
enables protein tyrosine kinase activity	EXP EXP: 通过实验结果推断	10861086	GOA
enables protein tyrosine kinase activity	IDA IDA: 通过直接分析推断	7519620	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in integrin-mediated signaling pathway	IMP IMP: 通过突变表型推断	7519620	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: 通过直接分析推断	7519620	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: 通过突变表型推断	10739672	GOA
involved in protein autophosphorylation	IDA IDA: 通过直接分析推断	2181286	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
colocalizes with cytoskeleton	IDA IDA: 通过直接分析推断	8603737	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FGR 蛋白结构

SH3_1

SH2

Pkinase_Tyr

0
100
200
300
400
500
529 a.a.

蛋白主名

其他名称

tyrosine-protein kinase Fgr

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog

FGR 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FGR	P09769	MET	Homo sapiens	P08581	FPS	24728074
种属内	FGR	P09769	KIT	Homo sapiens	P10721	FPS	24728074
种属内	FGR	P09769	EGFR	Homo sapiens	P00533	Lumier	24658140
种属内	FGR	P09769	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
种属内	FGR	P09769	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	22939624
种属内	FGR	P09769	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
种属内	FGR	P09769	AR	Homo sapiens	P10275	FPS	24728074
种属内	FGR	P09769	ERBB2	Homo sapiens	P04626	Protein Array	16273093
种属内	FGR	P09769	ALOX5	Homo sapiens	P09917	Protein Kinase Assay	24860872

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Placental Insufficiency

Uteroplacental Vascular Insufficiency

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Cd45 Deficiency

Co-Trimoxazole Allergy

Bactrim Allergy	Cotrimoxazol Allergy
Tmp/Smx Allergy	Trimethoprim/Sulfamethoxazole Allergy

Pfeiffer Syndrome

Infectious Mononucleosis	Acs5
Craniofacial-Skeletal-Dermatologic Dysplasia	Acs V
Noack Syndrome	Gammaherpesviral Mononucleosis
Acrocephalosyndactyly Type 5	Pfeiffer Syndrome Type 3
Acrocephalosyndactyly, Type V	Glandular Fever
Pfeiffer Type Acrocephalosyndactyly	Pfeiffer Syndrome Type 2
Acrocephalosyndactylia Type V	Filatov'S Disease
Monocytic Angina	Mononucleosis
Pfeiffer'S Disease	Acsv
Acrocephalosyndactyly, Type 5	Craniofacial-Skeletal-Dermatologic Syndrome
Pfeiffer Syndrome Type 1	Classic Pfeiffer Syndrome
PS	Pfeiffer Syndrome Variant
Dysplasia, Craniofacial-Skeletal-Dermatologic	Pfeiffer
Kissing Disease	Infectious Adenitis
Pfeiffer Disease

Pre-Eclampsia

Preeclampsia	Gestational Hypertension
Hypertension Induced By Pregnancy	Pre-Eclamptic Toxaemia
Pregnancy Associated Hypertension	Proteinuric Hypertension Of Pregnancy
Hypertension, Pregnancy-Induced, Susceptibility To	Preeclampsia/Eclampsia
Pregnancy Toxemia	Toxaemia Of Pregnancy
Gestational Proteinuric Hypertension	Pregnancy-Induced Hypertension
Toxemia Of Pregnancy	Preeclampsia, Susceptibility To
Transient Hypertension Of Pregnancy	Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria
Gestational Hypertension Nos	Mild Proteinuric Hypertension Of Pregnancy
Pih - [Pregnancy-Induced Hypertension]	Pregnancy-Induced Hypertension Nos
Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria	Pe - [Pre-Eclampsia]
Pre-Eclampsia Nos	Pre-Eclamptic Nos
Pregnancy Pre-Eclampsia	Puerperal Pre-Eclampsia
Pre-Eclampsia Toxaemia	Toxaemia In Pregnancy
Pet - [Pre-Eclamptic Toxaemia]	Maternal Toxaemia

Preterm Premature Rupture Of The Membranes

Preterm Premature Rupture Of Membranes	PPROM
Preterm Premature Rupture Of The Membranes, Susceptibility To	Pprom - [Preterm Premature Rupture Of Membranes]
Preterm Rupture Of Membranes

Oligohydramnios

Oligohydramnios - Delivered	Antepartum Oligohydramnios
Delivered Oligohydramnios	Oligohydramnios, Antepartum Condition Or Complication
Deficient Liquor	Oligohydramnios, Unspecified Trimester
Reduced Liquor Volume

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-10230	Midostaurin		99.91%	是

目录号	产品名	作用方式	纯度	Phase
HY-10234	Saracatinib		99.92%	Phase 3
HY-15322	PRT062607	Inhibitor	97.13%	Phase 2
HY-10186	TG 100801	Inhibitor	98.61%	Phase 2
HY-10187	TG 100801 Hydrochloride	Inhibitor	/	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-15141	Staurosporine		99.98%	否
HY-112852	TL02-59		99.84%	否
HY-10185	TG 100572 Hydrochloride	Inhibitor	98.96%	否
HY-10234A	Saracatinib difumarate	Inhibitor	99.24%	是
HY-10230S	Midostaurin-d5	Inhibitor	≥98.0%	否
HY-10184	TG 100572	Inhibitor	/	否
HY-112852A	TL02-59 dihydrochloride		/	否
HY-145373	BMS-986143	Inhibitor	/	否
HY-RS04929	FGR Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	FGR	VGNC	VGNC:40866
Bos taurus	FGR	VGNC	VGNC:28994
Mus musculus	FGR	MGD	MGI:95527
Rattus norvegicus	FGR	RGD	RGD:621319
Macaca mulatta	FGR	VGNC	VGNC:72658
Felis catus	FGR	VGNC	VGNC:62262
Others	FGR	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FGR - FGR proto-oncogene, Src family tyrosine kinase Gene

关于 FGR

功能概要

FGR 基因产物(3)

FGR 蛋白结构

FGR 蛋白互作信息

关联疾病

直系同源

热门区域

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FGR - FGR proto-oncogene, Src family tyrosine kinase Gene

关于 FGR

功能概要

FGR 基因产物(3)

FGR 蛋白结构

FGR 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z