2. Gene
  3. PHLPP2 - PH domain and leucine rich repeat protein phosphatase 2 Gene

PHLPP2 - PH domain and leucine rich repeat protein phosphatase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：PH 结构域和富亮氨酸的重复蛋白磷酸酶 2

种属: Homo sapiens

同用名: PPM3B; PHLPPL

基因 ID: 23035 | 基因类型: protein coding

关于 PHLPP2

Cytogenetic location: 16q22.2 Genomic coordinates (GRCh38): 16:71,644,924-71,724,701 (from NCBI)

This gene has 7 transcripts (splice variants), 186 orthologues and 31 paralogues. Broad expression in small intestine (RPKM 11.5), colon (RPKM 5.9) and 22 other tissues.

功能概要

预测启用蛋白质丝氨酸/苏氨酸磷酸酶活性。预计参与信号转导。位于多个细胞成分中，包括细胞间桥；有丝分裂纺锤体;和核质。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable protein serine/threonine Phosphatase activity. Predicted to be involved in signal transduction. Located in several cellular components, including intercellular bridge; mitotic spindle; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PHLPP2 基因产物(2)

mRNA Protein Name
NM_001289003.1 NP_001275932.1 PH domain leucine-rich repeat-containing protein phosphatase 2 isoform 2
NM_015020.3 NP_055835.2 PH domain leucine-rich repeat-containing protein phosphatase 2 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18162466 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PHLPP2 蛋白结构

LRR_1

LRR_1: Leucine Rich Repeat (324 - 344)

LRR_1

LRR_1: Leucine Rich Repeat (346 - 367)

LRR_8

LRR_8: Leucine rich repeat (572 - 632)

LRR_8

LRR_8: Leucine rich repeat (645 - 703)

PP2C

PP2C: Protein phosphatase 2C (849 - 1026)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1323 a.a.
蛋白主名 其他名称

PH domain leucine-rich repeat-containing protein phosphatase 2

protein phosphatase, Mg2+/Mn2+ dependent 3B

PHLPP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PHLPP2 Q6ZVD8 NHERF1 Homo sapiens O14745
Filter Binding
21804599
种属内
PHLPP2 Q6ZVD8 NHERF1 Homo sapiens O14745
Anti Tag CoIP
27880917
种属内
PHLPP2 Q6ZVD8 NHERF1 Homo sapiens O14745
Pull Down
21804599
种属内
PHLPP2 Q6ZVD8 NHERF1 Homo sapiens O14745
Anti Tag CoIP
19615732
种属内
PHLPP2 Q6ZVD8 PRKCB Homo sapiens P05771-2
Cosedimentation
18162466
种属间: 跨种属相互作用 种属内: 同种属相互作用

PHLPP2 抗体

目录号 产品名 应用 反应物种
HY-P81348 PHLPP2 Antibody (YA1093) IHC-P Human

关联疾病

疾病名称 别名
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Optic Atrophy 8

OPA8
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-19820A NSC45586 sodium ≥98.0% 否
HY-19820 NSC45586 / 否
HY-RS10448 PHLPP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PHLPP2 VGNC VGNC:44505
Bos taurus PHLPP2 VGNC VGNC:32841
Felis catus PHLPP2 VGNC VGNC:97553
Macaca mulatta PHLPP2 VGNC VGNC:81494
Rattus norvegicus PHLPP2 RGD RGD:1562857
Mus musculus PHLPP2 MGD MGI:2444928
Others PHLPP2 NCBI
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