FLII - FLII actin remodeling protein Gene

中文名称：FLII 肌动蛋白重塑蛋白

种属: Homo sapiens

同用名: FLI; FLIL; Fli1

基因 ID: 2314 | 基因类型: protein coding

关于 FLII

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:18,244,815-18,259,022 (from NCBI)

This gene has 30 transcripts (splice variants), 1 gene allele, 203 orthologues, 7 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 32.8), spleen (RPKM 32.4) and 25 other tissues.

功能概要

该基因编码的蛋白质具有凝溶胶蛋白样肌动蛋白结合域和 N 末端富含亮氨酸的重复蛋白质相互作用域。该蛋白质类似于参与早期胚胎发生和间接飞行肌肉结构组织的果蝇蛋白质。该基因位于 17 号染色体上的 Smith-Magenis 综合征区域内。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

FLII 基因产物(3)

mRNA	Protein	Name
NM_001256264.2	NP_001243193.1	protein flightless-1 homolog isoform 2
NM_001256265.2	NP_001243194.1	protein flightless-1 homolog isoform 3
NM_002018.4	NP_002009.1	protein flightless-1 homolog isoform 1

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables actin binding	IDA IDA: 通过直接分析推断	9525888	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9671805	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FLII 蛋白结构

LRR_1

LRR_8

LRR_4

Gelsolin

0
200
400
600
800
1000
1200
1269 a.a.

蛋白主名

其他名称

protein flightless-1 homolog

flightless I actin binding protein

FLII 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	FLII	Q13045	LRRFIP2	Homo sapiens	Q9Y608	Anti Tag CoIP	33961781
Intra	FLII	Q13045	LRRFIP1	Homo sapiens	Q32MZ4	Anti Tag CoIP	33961781
Intra	FLII	Q13045	LRRFIP1	Homo sapiens	Q32MZ4	Y2H	10366446

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Smith-Magenis Syndrome

SMS	Chromosome 17p11.2 Deletion Syndrome
17p11.2 Microdeletion Syndrome	17p11.2 Monosomy
Chromosome 17p Deletion Syndrome	Del(17)
P11.2	17p- Syndrome
Deletion 17p Syndrome	Partial Monosomy 17p

Askin'S Tumor

Askin Tumor	Askin Tumour
Askin'S Tumour

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Ewing Sarcoma Of Bone

Ewing'S Sarcoma Of Bone	Bone Ewing Sarcoma
Bone Ewing'S Sarcoma	Bone Localized Ewing Sarcoma
Bone Localized Ewing'S Sarcoma	Ewing'S Sarcoma/Bone Peripheral Primitive Neuroectodermal Tumor
Localized Skeletal Ewing'S Sarcoma	Localized Bone Ewing Sarcoma

Skin Angiosarcoma

Angiosarcoma Of Skin	Hemangiosarcoma Of The Skin
Haemangiosarcoma Of Skin	Lymphangiosarcoma Of Skin
Cutaneous Angiosarcoma	Malignant Haemangioendothelioma Of Skin

Desmoplastic Small Round Cell Tumor

Dsrct	Desmoplastic Small Round-Cell Tumor
Desmoplastic Small Round-Cell Neoplasm

Rhabdomyosarcoma 2

Alveolar Rhabdomyosarcoma	Rhabdomyosarcoma, Alveolar
Rhabdomyosarcoma Alveolar	RMS2
Rmsa	Rhabdomyosarcoma 2, Alveolar
Alveolar Childhood Rhabdomyosarcoma	Arms
Rhabdomyosarcoma, Type 2

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04978	FLII Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	FLII	RGD	RGD:1307590
Macaca mulatta	FLII	VGNC	VGNC:72670
Canis familiaris	FLII	VGNC	VGNC:40899
Bos taurus	FLII	VGNC	VGNC:29032
Felis catus	FLII	VGNC	VGNC:62290
Mus musculus	FLII	MGD	MGI:1342286
Others	FLII	NCBI

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