2. Gene
  3. LRRFIP2 - LRR binding FLII interacting protein 2 Gene

LRRFIP2 - LRR binding FLII interacting protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：LRR 结合 FLII 相互作用蛋白 2

种属: Homo sapiens

同用名: HUFI-2

基因 ID: 9209 | 基因类型: protein coding

关于 LRRFIP2

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:37,052,626-37,176,360 (from NCBI)

This gene has 20 transcripts (splice variants), 214 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 17.9), heart (RPKM 16.5) and 25 other tissues.

功能概要

由该基因编码的蛋白质与 MyD88 一起结合到 toll 样受体 4 (TLR4) 的胞质尾部，从而激活核因子 kappa B 信号转导。泛素样蛋白 FAT10 阻止编码蛋白与 TLR4 的相互作用，从而使核因子 kappa B 信号通路失活。此外，这种蛋白质可以通过将 Caspase-1 抑制剂 Flightless-I 募集到炎性体复合体来下调 NLRP3 炎性体。[RefSeq 提供，2017 年 1 月]

The protein encoded by this gene, along with MyD88, binds to the cytosolic tail of Toll-like Receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the Caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]

LRRFIP2 基因产物(19)

mRNA Protein Name
NM_001134369.2 NP_001127841.1 leucine-rich repeat flightless-interacting protein 2 isoform k
NM_001282691.1 NP_001269620.1 leucine-rich repeat flightless-interacting protein 2 isoform d
NM_001348297.1 NP_001335226.1 leucine-rich repeat flightless-interacting protein 2 isoform b
NM_001348298.1 NP_001335227.1 leucine-rich repeat flightless-interacting protein 2 isoform c
NM_001348299.1 NP_001335228.1 leucine-rich repeat flightless-interacting protein 2 isoform e
NM_001348300.1 NP_001335229.1 leucine-rich repeat flightless-interacting protein 2 isoform e
NM_001348301.1 NP_001335230.1 leucine-rich repeat flightless-interacting protein 2 isoform f
NM_001348302.1 NP_001335231.1 leucine-rich repeat flightless-interacting protein 2 isoform f
NM_001348303.1 NP_001335232.1 leucine-rich repeat flightless-interacting protein 2 isoform g
NM_001348304.1 NP_001335233.1 leucine-rich repeat flightless-interacting protein 2 isoform h
NM_001348305.1 NP_001335234.1 leucine-rich repeat flightless-interacting protein 2 isoform i
NM_001348306.1 NP_001335235.1 leucine-rich repeat flightless-interacting protein 2 isoform i
NM_001348307.1 NP_001335236.1 leucine-rich repeat flightless-interacting protein 2 isoform i
NM_001348308.1 NP_001335237.1 leucine-rich repeat flightless-interacting protein 2 isoform j
NM_001348309.1 NP_001335238.1 leucine-rich repeat flightless-interacting protein 2 isoform j
NM_001348310.1 NP_001335239.1 leucine-rich repeat flightless-interacting protein 2 isoform k
NM_001348311.1 NP_001335240.1 leucine-rich repeat flightless-interacting protein 2 isoform l
NM_006309.4 NP_006300.1 leucine-rich repeat flightless-interacting protein 2 isoform a
NM_017724.2 NP_060194.1 leucine-rich repeat flightless-interacting protein 2 isoform l
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables LRR domain binding IPI
IPI: 通过物理相互作用推断
10366446 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10366446 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LRRFIP2 蛋白结构

LRRFIP

LRRFIP: LRRFIP family (31 - 112)

LRRFIP

LRRFIP: LRRFIP family (292 - 459)

LRRFIP

LRRFIP: LRRFIP family (458 - 646)

  • 0
  • 200
  • 400
  • 600
  • 721 a.a.
蛋白主名 其他名称

leucine-rich repeat flightless-interacting protein 2

LRR FLII-interacting protein 2

LRRFIP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra LRRFIP2 Q9Y608 ATPAF2 Homo sapiens Q8N5M1
Y2H Array
31515488
Intra LRRFIP2 Q9Y608 ATPAF2 Homo sapiens Q8N5M1
Y2H Prey Pooling
25416956
Intra LRRFIP2 Q9Y608 ATPAF2 Homo sapiens Q8N5M1
Y2H Array
25416956
Intra LRRFIP2 Q9Y608 FLII Homo sapiens Q13045
Y2H
10366446
Intra LRRFIP2 Q9Y608 DVL3 Homo sapiens Q92997
Anti Tag CoIP
15677333
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer

Hereditary Nonpolyposis Colorectal Cancer

Hereditary Nonpolyposis Colorectal Carcinoma

Hereditary Nonpolyposis Colorectal Neoplasms

Familial Nonpolyposis Colon Cancer

Hnpcc

Coca 1

Hereditary Defective Mismatch Repair Syndrome

Hereditary Non-Polyposis Colon Cancer

Hereditary Non-Polyposis Colon Cancer Syndrome

Hereditary Non-Polyposis Colorectal Cancer

Hereditary Non-Polyposis Colorectal Cancer Syndrome

Hereditary Nonpolyposis Colon Cancer Syndrome

Hereditary Nonpolyposis Colorectal Cancer Syndrome

Hereditary Nonpolyposis Colorectal Neoplasm

Hnpcc - Hereditary Nonpolyposis Colon Cancer

Cancer Family Syndrome

Familial Nonpolyposis Colorectal Cancer

Colon Cancer, Familial Nonpolyposis

Colorectal Neoplasms, Hereditary Nonpolyposis

Cancer, Colorectal, Nonpolyposis, Hereditary

Colorectal Cancer, Hereditary Nonpolyposis, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07831 LRRFIP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus LRRFIP2 VGNC VGNC:31035
Rattus norvegicus LRRFIP2 RGD RGD:1306234
Canis familiaris LRRFIP2 VGNC VGNC:42820
Macaca mulatta LRRFIP2 VGNC VGNC:74449
Mus musculus LRRFIP2 MGD MGI:1918518
Felis catus LRRFIP2 VGNC VGNC:68094
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