2. Gene
  3. FLOT2 - flotillin 2 Gene

FLOT2 - flotillin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：弗洛替林 2

种属: Homo sapiens

同用名: ESA; ECS1; ESA1; ECS-1; M17S1

基因 ID: 2319 | 基因类型: protein coding

关于 FLOT2

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,879,339-28,897,733 (from NCBI)

This gene has 12 transcripts (splice variants), 279 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 42.8), spleen (RPKM 42.2) and 25 other tissues.

功能概要

小窝是内细胞膜上参与囊泡运输和信号转导的小区域。该基因编码一种与细胞膜穴样内陷相关的完整膜蛋白，该蛋白被认为在神经元信号传导中发挥作用。[RefSeq 提供，2008 年 7 月]

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in Neuronal Signaling. [provided by RefSeq, Jul 2008]

FLOT2 基因产物(2)

mRNA Protein Name
NM_001330170.2 NP_001317099.1 flotillin-2 isoform 2
NM_004475.3 NP_004466.2 flotillin-2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17113085 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of amyloid precursor protein catabolic process IMP
IMP: 通过突变表型推断
24612608 GOA
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
24612608 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
23319823 GOA
involved in positive regulation of establishment of T cell polarity IMP
IMP: 通过突变表型推断
21696602 GOA
involved in protein localization to plasma membrane IMP
IMP: 通过突变表型推断
24612608 GOA
involved in protein localization to plasma membrane raft IMP
IMP: 通过突变表型推断
21696602 GOA
involved in protein stabilization IMP
IMP: 通过突变表型推断
24612608 GOA
NOT involved in regulation of heterotypic cell-cell adhesion IMP
IMP: 通过突变表型推断
25204797 GOA
involved in regulation of myoblast differentiation IEP
IEP: 通过表达模式推断
25105415 GOA
NOT involved in regulation of toll-like receptor 3 signaling pathway IMP
IMP: 通过突变表型推断
25204797 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in adherens junction IDA
IDA: 通过直接分析推断
24046456 GOA
NOT located in apical plasma membrane IDA
IDA: 通过直接分析推断
23983584 GOA
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
23983584 GOA
located in caveola IDA
IDA: 通过直接分析推断
24013648 GOA
located in cell-cell contact zone IDA
IDA: 通过直接分析推断
23983584 GOA
colocalizes with cortical actin cytoskeleton IDA
IDA: 通过直接分析推断
24046456 GOA
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
23983584 GOA
located in endocytic vesicle IDA
IDA: 通过直接分析推断
20682791 GOA
located in endosome IDA
IDA: 通过直接分析推断
20682791 GOA
part of flotillin complex IDA
IDA: 通过直接分析推断
21696602 GOA
located in lamellipodium IDA
IDA: 通过直接分析推断
24046456 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
21119006 GOA
located in plasma membrane IMP
IMP: 通过突变表型推断
21696602 GOA
located in uropod IDA
IDA: 通过直接分析推断
21696602 GOA
located in vesicle IDA
IDA: 通过直接分析推断
21119006 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FLOT2 蛋白结构

Band_7

Band_7: SPFH domain / Band 7 family (6 - 188)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 428 a.a.
蛋白主名 其他名称

flotillin-2

Flotillin 2 (epidermal surface antigen 1)

FLOT2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FLOT2 Q14254 FLOT1 Homo sapiens O75955
Confocal
24167781
种属内
FLOT2 Q14254 FLOT1 Homo sapiens O75955
Crosslink
30021884
种属内
FLOT2 Q14254 FLOT1 Homo sapiens O75955
Far-WB
17113085
种属内
FLOT2 Q14254 SNCG Homo sapiens Q6FHG5
Anti Bait CoIP
25229320
种属间: 跨种属相互作用 种属内: 同种属相互作用

FLOT2 抗体

目录号 产品名 应用 反应物种
HY-P81694 Flotillin 2 Antibody (YA1439) WB, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04983 FLOT2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus FLOT2 RGD RGD:70993
Mus musculus FLOT2 MGD MGI:103309
Bos taurus FLOT2 VGNC VGNC:29037
Felis catus FLOT2 VGNC VGNC:62295
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