FLOT1 - flotillin 1 Gene

中文名称：flotillin 1

种属: Homo sapiens

基因 ID: 10211 | 基因类型: protein coding

关于 FLOT1

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:30,727,709-30,742,687 (from NCBI)

This gene has 12 transcripts (splice variants), 1 gene allele, 279 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 66.3), heart (RPKM 56.6) and 25 other tissues.

功能概要

该基因编码一种定位于小窝的蛋白质，小窝是内细胞膜上的小区域。这种蛋白质在囊泡运输和细胞形态学中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 1 月]

This gene encodes an protein that localizes to the caveolae, which are small domains on the inner cell membranes. This protein plays a role in vesicle trafficking and cell morphology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

FLOT1 基因产物(2)

mRNA	Protein	Name
NM_001318875.2	NP_001305804.1	flotillin-1 isoform 2
NM_005803.4	NP_005794.1	flotillin-1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protease binding	IPI IPI: 通过物理相互作用推断	24612608	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15469992	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to exogenous dsRNA	IMP IMP: 通过突变表型推断	25204797	GOA
involved in dsRNA transport	IMP IMP: 通过突变表型推断	25204797	GOA
involved in extracellular matrix disassembly	IMP IMP: 通过突变表型推断	21119006	GOA
involved in intracellular signal transduction	IMP IMP: 通过突变表型推断	21399631	GOA
involved in plasma membrane raft assembly	IMP IMP: 通过突变表型推断	21399631	GOA
acts upstream of positive effect plasma membrane raft organization	IMP IMP: 通过突变表型推断	25204797	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: 通过突变表型推断	23319823	GOA
involved in positive regulation of cell junction assembly	IMP IMP: 通过突变表型推断	24046456	GOA
involved in positive regulation of cell-cell adhesion mediated by cadherin	IMP IMP: 通过突变表型推断	24046456	GOA
involved in positive regulation of cytokine production	IMP IMP: 通过突变表型推断	25204797	GOA
involved in positive regulation of endocytosis	IMP IMP: 通过突变表型推断	21399631	GOA
involved in positive regulation of heterotypic cell-cell adhesion	IMP IMP: 通过突变表型推断	25204797	GOA
involved in positive regulation of interferon-beta production	IMP IMP: 通过突变表型推断	25204797	GOA
involved in positive regulation of myoblast fusion	IMP IMP: 通过突变表型推断	24046456	GOA
involved in positive regulation of protein binding	IMP IMP: 通过突变表型推断	24046456	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: 通过突变表型推断	25204797	GOA
involved in positive regulation of skeletal muscle tissue development	IMP IMP: 通过突变表型推断	24046456	GOA
involved in positive regulation of toll-like receptor 3 signaling pathway	IMP IMP: 通过突变表型推断	25204797	GOA
involved in protein localization to plasma membrane	IMP IMP: 通过突变表型推断	24046456	GOA
involved in protein stabilization	IMP IMP: 通过突变表型推断	25204797	GOA
involved in regulation of neurotransmitter uptake	IDA IDA: 通过直接分析推断	21399631	GOA
involved in regulation of neurotransmitter uptake	IMP IMP: 通过突变表型推断	21399631	GOA
involved in regulation of receptor internalization	IMP IMP: 通过突变表型推断	21399631	GOA
NOT involved in regulation of toll-like receptor 4 signaling pathway	IMP IMP: 通过突变表型推断	25204797	GOA
involved in response to endoplasmic reticulum stress	IMP IMP: 通过突变表型推断	25204797	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of COP9 signalosome	IDA IDA: 通过直接分析推断	18850735	GOA
located in adherens junction	IDA IDA: 通过直接分析推断	24046456	GOA
NOT located in apical plasma membrane	IDA IDA: 通过直接分析推断	23983584	GOA
located in basolateral plasma membrane	IDA IDA: 通过直接分析推断	23983584	GOA
located in cell-cell contact zone	IDA IDA: 通过直接分析推断	23983584	GOA
located in cell-cell junction	IDA IDA: 通过直接分析推断	25468996	GOA
located in centriolar satellite	IDA IDA: 通过直接分析推断	18000879	GOA
colocalizes with cortical actin cytoskeleton	IDA IDA: 通过直接分析推断	24046456	GOA
located in cytoplasmic vesicle	IDA IDA: 通过直接分析推断	23983584	GOA
is active in dopaminergic synapse	IDA IDA: 通过直接分析推断	21399631	GOA
is active in dopaminergic synapse	IMP IMP: 通过突变表型推断	21399631	GOA
located in early endosome	IDA IDA: 通过直接分析推断	21399631	GOA
located in endosome	IDA IDA: 通过直接分析推断	20682791	GOA
part of flotillin complex	IDA IDA: 通过直接分析推断	21399631	GOA
located in lamellipodium	IDA IDA: 通过直接分析推断	24046456	GOA
located in membrane raft	IDA IDA: 通过直接分析推断	15469992	GOA
located in microtubule organizing center	IDA IDA: 通过直接分析推断	18000879	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	21399631	GOA
located in plasma membrane	IMP IMP: 通过突变表型推断	21696602	GOA
located in uropod	IDA IDA: 通过直接分析推断	21696602	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FLOT1 蛋白结构

Band_7

0
100
200
300
400
427 a.a.

蛋白主名

其他名称

flotillin-1

integral membrane component of caveolae

FLOT1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FLOT1	O75955	CCDC102B	Homo sapiens	Q68D86	Validated Y2H	32296183
种属内	FLOT1	O75955	COX5B	Homo sapiens	P10606	Validated Y2H	32296183
种属内	FLOT1	O75955	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
种属内	FLOT1	O75955	FLOT2	Homo sapiens	Q14254	PLA	24167781
种属内	FLOT1	O75955	FLOT2	Homo sapiens	Q14254	IF	24809731
种属内	FLOT1	O75955	EMP3	Homo sapiens	P54852	PLA	30614533
种属内	FLOT1	O75955	EMP3	Homo sapiens	P54852	BiFC	30614533
种属内	FLOT1	O75955	HTT	Homo sapiens	P42858	Y2H Array	32814053
种属内	FLOT1	O75955	HTT	Homo sapiens	P42858	Validated Y2H	32814053
种属内	FLOT1	O75955	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
种属内	FLOT1	O75955	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	32296183
种属内	FLOT1	O75955	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
种属内	FLOT1	O75955	APP	Homo sapiens	P05067	Anti Bait CoIP	16480949
种属内	FLOT1	O75955	APP	Homo sapiens	P05067	Y2H	16480949

种属间: 跨种属相互作用 种属内: 同种属相互作用

FLOT1 抗体

目录号	产品名	应用	反应物种
HY-P80675	Flotillin 1 Antibody (YA760)	WB	Mouse, Rat

关联疾病

疾病名称

别名

Mycobacterium Marinum

Mycobacterium Marinum Infection	Fish Tank Granuloma
M. Marinum

Open-Angle Glaucoma

Glaucoma Simplex	Pigmentary Glaucoma
Wide-Angle Glaucoma	Glaucoma, Open-Angle
Open Angle Glaucoma	Glaucoma Open-Angle
Chronic Simple Glaucoma	Coag - [Chronic Open-Angle Glaucoma]
Csg - [Chronic Simple Glaucoma]	Poag - [Primary Open-Angle Glaucoma]
Oag - [Open-Angle Glaucoma]	Chronic Glaucoma
Chronic Open Angle Glaucoma	Simple Glaucoma
Chronic Noncongestive Glaucoma	Ltg - [Low Tension Glaucoma]
Noncongestive Glaucoma	Nonobstructive Glaucoma
Normal Pressure Glaucoma	Primary Low Tension Glaucoma
Low-Tension Glaucoma	Residual Stage Low Tension Glaucoma
Open Cleft Glaucoma

Cortical Dysplasia, Complex, With Other Brain Malformations 6

Complex Cortical Dysplasia With Other Brain Malformations 6	CDCBM6
Cdcbm56	Dysplasia ,Cortical, Complex, With Other Brain Malformations, Type 6

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04982	FLOT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	FLOT1	RGD	RGD:70991
Felis catus	FLOT1	VGNC	VGNC:62294
Macaca mulatta	FLOT1	VGNC	VGNC:72674
Bos taurus	FLOT1	VGNC	VGNC:29036
Canis familiaris	FLOT1	VGNC	VGNC:40903
Mus musculus	FLOT1	MGD	MGI:1100500

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FLOT1 - flotillin 1 Gene

关于 FLOT1

功能概要

FLOT1 基因产物(2)

FLOT1 蛋白结构

FLOT1 蛋白互作信息

FLOT1 抗体

关联疾病

直系同源

热门区域

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FLOT1 - flotillin 1 Gene

关于 FLOT1

功能概要

FLOT1 基因产物(2)

FLOT1 蛋白结构

FLOT1 蛋白互作信息

FLOT1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z