2. Gene
  3. PHLPP1 - PH domain and leucine rich repeat protein phosphatase 1 Gene

PHLPP1 - PH domain and leucine rich repeat protein phosphatase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：PH 结构域和富亮氨酸的重复蛋白磷酸酶 1

种属: Homo sapiens

同用名: SCOP; PHLPP; PPM3A; PLEKHE1

基因 ID: 23239 | 基因类型: protein coding

关于 PHLPP1

Cytogenetic location: 18q21.33 Genomic coordinates (GRCh38): 18:62,715,541-62,980,433 (from NCBI)

This gene has 7 transcripts (splice variants), 246 orthologues and 31 paralogues. Broad expression in brain (RPKM 17.2), testis (RPKM 8.3) and 25 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸磷酸酶家族的一个成员。编码的蛋白质通过使丝氨酸/苏氨酸激酶 Akt 去磷酸化和失活来促进细胞凋亡，并在多种类型的癌症中发挥肿瘤抑制因子的作用。该基因表达增加还可能通过干扰 Akt 介导的胰岛素信号传导在肥胖和 2 型糖尿病中发挥作用。[RefSeq 提供，2011 年 12 月]

This gene encodes a member of the serine/threonine Phosphatase family. The encoded protein promotes Apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of Cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated Insulin signaling. [provided by RefSeq, Dec 2011]

PHLPP1 基因产物(1)

mRNA Protein Name
NM_194449.4 NP_919431.2 PH domain leucine-rich repeat-containing protein phosphatase 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18162466 GOA
enables protein serine/threonine phosphatase activity IDA
IDA: 通过直接分析推断
28147277 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
17386267 GOA
involved in regulation of JNK cascade IDA
IDA: 通过直接分析推断
17386267 GOA
involved in regulation of MAPK cascade IMP
IMP: 通过突变表型推断
24530606 GOA
involved in regulation of apoptotic process IDA
IDA: 通过直接分析推断
20513427 GOA
involved in regulation of p38MAPK cascade IDA
IDA: 通过直接分析推断
17386267 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PHLPP1 蛋白结构

LRR_1

LRR_1: Leucine Rich Repeat (692 - 709)

LRR_8

LRR_8: Leucine rich repeat (714 - 771)

LRR_1

LRR_1: Leucine Rich Repeat (918 - 939)

LRR_8

LRR_8: Leucine rich repeat (1014 - 1072)

PP2C

PP2C: Protein phosphatase 2C (1177 - 1415)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1717 a.a.
蛋白主名 其他名称

PH domain leucine-rich repeat-containing protein phosphatase 1

PH domain-containing family E member 1

PHLPP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PHLPP1 O60346 SCRIB Homo sapiens Q14160
Anti Tag CoIP
19615732
种属内
PHLPP1 O60346 SCRIB Homo sapiens Q14160
Anti Bait CoIP
21701506
种属内
PHLPP1 O60346 PRKCB Homo sapiens P05771-2
Cosedimentation
18162466
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Uterine Corpus Endometrial Carcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-19820A NSC45586 sodium ≥98.0% 否
HY-19820 NSC45586 / 否
HY-RS10447 PHLPP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PHLPP1 VGNC VGNC:44504
Bos taurus PHLPP1 VGNC VGNC:32840
Macaca mulatta PHLPP1 VGNC VGNC:81493
Rattus norvegicus PHLPP1 RGD RGD:621308
Felis catus PHLPP1 VGNC VGNC:107716
Mus musculus PHLPP1 MGD MGI:2138327
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