1. Gene
  2. BOP1 - BOP1 ribosomal biogenesis factor Gene

BOP1 - BOP1 ribosomal biogenesis factor Gene

中文名称:BOP1 核糖体生物发生因子

种属: Homo sapiens

基因 ID: 23246 | 基因类型: protein coding

关于 BOP1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,262,045-144,291,438 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele and 182 orthologues. Ubiquitous expression in testis (RPKM 10.2), appendix (RPKM 9.2) and 25 other tissues.

功能概要

启用 RNA 结合活性。参与细胞周期的调节; p53 类介质调节信号转导;和核糖体大亚基生物发生。位于染色体;核仁;和核质。 PeBoW 复合体的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Enables RNA binding activity. Involved in regulation of cell cycle; regulation of signal transduction by p53 class mediator; and ribosomal large subunit biogenesis. Located in chromosome; nucleolus; and nucleoplasm. Part of PeBoW complex. [provided by Alliance of Genome Resources, Apr 2022]

BOP1 基因产物(1)

mRNA Protein Name
NM_015201.5 NP_056016.1 ribosome biogenesis protein BOP1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16043514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
IMP: 通过突变表型推断
17353269 GOA
involved in regulation of cell cycle IMP
IMP: 通过突变表型推断
16043514 GOA
involved in regulation of signal transduction by p53 class mediator IMP
IMP: 通过突变表型推断
24120868 GOA
involved in ribosomal large subunit assembly IMP
IMP: 通过突变表型推断
24120868 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of PeBoW complex IDA
IDA: 通过直接分析推断
16043514 GOA
part of ribonucleoprotein complex IDA
IDA: 通过直接分析推断
18809582 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

BOP1 蛋白结构

BOP1NT

BOP1NT: BOP1NT (NUC169) domain (144 - 402)

WD40

WD40: WD domain, G-beta repeat (408 - 441)

WD40

WD40: WD domain, G-beta repeat (655 - 689)

WD40

WD40: WD domain, G-beta repeat (720 - 745)

  • 0
  • 200
  • 400
  • 600
  • 746 a.a.
蛋白主名 其他名称

ribosome biogenesis protein BOP1

block of proliferation 1

BOP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
BOP1 Q14137 PES1 Homo sapiens O00541 16043514
种属内
BOP1 Q14137 PES1 Homo sapiens O00541 16043514
种属内
BOP1 Q14137 WDR12 Homo sapiens Q9GZL7 16043514
种属内
BOP1 Q14137 WDR12 Homo sapiens Q9GZL7 16043514
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta BOP1 VGNC VGNC:70315
Felis catus BOP1 VGNC VGNC:60149
Canis familiaris BOP1 VGNC VGNC:38498
Mus musculus BOP1 MGD MGI:1334460
Bos taurus BOP1 VGNC VGNC:26540
Rattus norvegicus BOP1 RGD RGD:1310589