UBR4 - ubiquitin protein ligase E3 component n-recognin 4 Gene

中文名称：泛素蛋白连接酶 E3 组分 n-识别素 4

种属: Homo sapiens

同用名: p600; ZUBR1; RBAF600

基因 ID: 23352 | 基因类型: protein coding

关于 UBR4

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,074,510-19,210,266 (from NCBI)

This gene has 17 transcripts (splice variants) and 228 orthologues. Ubiquitous expression in testis (RPKM 21.2), bone marrow (RPKM 14.0) and 25 other tissues.

功能概要

由该基因编码的蛋白质是一种 E3 泛素蛋白连接酶，它与细胞核中的视网膜母细胞瘤相关蛋白和细胞质中的钙结合钙调蛋白相互作用。编码的蛋白质似乎是细胞质中的细胞骨架成分和细胞核中染色质支架的一部分。此外，该蛋白是人乳头瘤病毒 16 型 E7 癌蛋白的靶标。[RefSeq 提供，2010 年 8 月]

The protein encoded by this gene is an E3 ubiquitin-protein Ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound Calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]

UBR4 基因产物(1)

mRNA	Protein	Name
NM_020765.3	NP_065816.2	E3 ubiquitin-protein ligase UBR4

UBR4 蛋白结构

zf-UBR

E3_UbLigase_R4

0
800
1600
2400
3200
4000
4800
5183 a.a.

蛋白主名

其他名称

E3 ubiquitin-protein ligase UBR4

N-recognin-4

UBR4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	UBR4	Q5T4S7	E7	Human papillomavirus	P06464	CoIP	16061792
种属间	UBR4	Q5T4S7	E7	Human papillomavirus	P03129	CoIP	16061792
种属间	UBR4	Q5T4S7	E7	Human papillomavirus	P03129	Anti Bait CoIP	16061792
种属间	UBR4	Q5T4S7	E7	Human papillomavirus	P03129	Affinity Chrom	16061792

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Rift Valley Fever

Rfv - [Rift Valley Fever]

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Episodic Ataxia, Type 8

Episodic Ataxia Type 8	EA8
Episodic Ataxia With Slurred Speech

Episodic Ataxia, Type 4

Episodic Ataxia Type 4	Periodic Vestibulocerebellar Ataxia
Patx	EA4
Ataxia, Periodic Vestibulocerebellar

Johanson-Blizzard Syndrome

JBS	Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia, And Congenital Deafness
Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia And Congenital Deafness	Johanson Blizzard Syndrome

Episodic Ataxia, Type 3

Episodic Ataxia Type 3	EA3
Ataxia, Episodic, With Vertigo And Tinnitus	Episodic Ataxia-Vertigo-Tinnitus-Myokymia Syndrome

Episodic Ataxia, Type 7

Episodic Ataxia Type 7

EA7

Episodic Ataxia, Type 5

Episodic Ataxia Type 5	EA5
Episodic Ataxia 5	Ea-5
Ataxia, Episodic, Type 5

Severe Congenital Neutropenia 4

Autosomal Recessive Severe Congenital Neutropenia Due To G6pc3 Deficiency	Scn4
Severe Congenital Neutropenia-Pulmonary Hypertension-Superficial Venous Angiectasis Syndrome	Dursun Syndrome
Severe Congenital Neutropenia Type 4

Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis	Epidermodysplasia Verruciformis, Susceptibility To, 1
Lutz-Lewandowsky Epidermodysplasia Verruciformis	EV1
Lewandowsky-Lutz Syndrome	Ev

Episodic Ataxia

Isaacs Syndrome	Neuromyotonia
Isaacs' Syndrome	Acquired Neuromyotonia
Continuous Muscle Fiber Activity Syndrome	Quantal Squander Syndrome
Isaacs-Mertens Syndrome	Ea Syndrome
Episodic Ataxia Syndrome	Isaac Syndrome
Isaac'S-Merten'S Syndrome	Isaac-Mertens Syndrome
Peripheral Nerve Hyperexcitability	Ea
Peripheral Nerve Hyperexcitability Syndrome	Ataxia, Episodic
Isaacs Neuromyotonia	Continuous Muscle Fibre Activity

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15389	UBR4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	UBR4	RGD	RGD:1563121
Mus musculus	UBR4	MGD	MGI:1916366
Felis catus	UBR4	VGNC	VGNC:66787
Macaca mulatta	UBR4	VGNC	VGNC:79845
Bos taurus	UBR4	VGNC	VGNC:36618
Canis familiaris	UBR4	VGNC	VGNC:48091

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

UBR4 - ubiquitin protein ligase E3 component n-recognin 4 Gene

关于 UBR4

功能概要

UBR4 基因产物(1)

UBR4 蛋白结构

UBR4 蛋白互作信息

关联疾病

直系同源

热门区域

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UBR4 - ubiquitin protein ligase E3 component n-recognin 4 Gene

关于 UBR4

功能概要

UBR4 基因产物(1)

UBR4 蛋白结构

UBR4 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z