2. Gene
  3. PUM2 - pumilio RNA binding family member 2 Gene

PUM2 - pumilio RNA binding family member 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：pumilio RNA 结合家族成员 2

种属: Homo sapiens

同用名: PUMH2; PUML2

基因 ID: 23369 | 基因类型: protein coding

关于 PUM2

Cytogenetic location: 2p24.1 Genomic coordinates (GRCh38): 2:20,248,691-20,352,253 (from NCBI)

This gene has 10 transcripts (splice variants), 204 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 13.0), lymph node (RPKM 9.6) and 25 other tissues.

功能概要

该基因编码的蛋白质属于 RNA 结合蛋白家族。编码的蛋白质在胚胎发育和细胞分化过程中起翻译抑制因子的作用。这种蛋白质也被认为是脂肪来源干细胞中细胞增殖的正调节剂。交替剪接导致多个转录本变体。[RefSeq 提供，2013 年 9 月]

This gene encodes a protein that belongs to a family of RNA-binding proteins. The encoded protein functions as a translational repressor during embryonic development and cell differentiation. This protein is also thought to be a positive regulator of cell proliferation in adipose-derived stem cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

PUM2 基因产物(15)

mRNA Protein Name
NM_001282752.3 NP_001269681.1 pumilio homolog 2 isoform 2
NM_001282790.2 NP_001269719.1 pumilio homolog 2 isoform 3
NM_001282791.2 NP_001269720.1 pumilio homolog 2 isoform 4
NM_001352917.3 NP_001339846.1 pumilio homolog 2 isoform 5
NM_001352918.2 NP_001339847.1 pumilio homolog 2 isoform 1
NM_001352919.3 NP_001339848.1 pumilio homolog 2 isoform 1
NM_001352920.3 NP_001339849.1 pumilio homolog 2 isoform 6
NM_001352923.3 NP_001339852.1 pumilio homolog 2 isoform 6
NM_001352925.3 NP_001339854.1 pumilio homolog 2 isoform 3
NM_001352926.2 NP_001339855.1 pumilio homolog 2 isoform 3
NM_001352927.3 NP_001339856.1 pumilio homolog 2 isoform 3
NM_001352928.3 NP_001339857.1 pumilio homolog 2 isoform 3
NM_001352929.3 NP_001339858.1 pumilio homolog 2 isoform 4
NM_001352930.3 NP_001339859.1 pumilio homolog 2 isoform 7
NM_015317.5 NP_056132.1 pumilio homolog 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
26724866 GOA
enables mRNA 3'-UTR binding IDA
IDA: 通过直接分析推断
18776931 GOA
enables miRNA binding IDA
IDA: 通过直接分析推断
28431233 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12511597 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in miRNA processing IMP
IMP: 通过突变表型推断
28431233 GOA
involved in positive regulation of RIG-I signaling pathway IDA
IDA: 通过直接分析推断
25340845 GOA
involved in positive regulation of miRNA-mediated gene silencing IMP
IMP: 通过突变表型推断
22345517 GOA
acts upstream of or within post-transcriptional regulation of gene expression IDA
IDA: 通过直接分析推断
25100735 GOA
acts upstream of positive effect post-transcriptional regulation of gene expression IMP
IMP: 通过突变表型推断
28431233 GOA
involved in regulation of chromosome segregation IDA
IDA: 通过直接分析推断
26724866 GOA
involved in regulation of mRNA stability IDA
IDA: 通过直接分析推断
26724866 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic stress granule IDA
IDA: 通过直接分析推断
25340845 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
19168546 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PUM2 蛋白结构

PUF

PUF: Pumilio-family RNA binding repeat (727 - 760)

PUF

PUF: Pumilio-family RNA binding repeat (763 - 791)

PUF

PUF: Pumilio-family RNA binding repeat (799 - 830)

PUF

PUF: Pumilio-family RNA binding repeat (835 - 862)

PUF

PUF: Pumilio-family RNA binding repeat (871 - 904)

PUF

PUF: Pumilio-family RNA binding repeat (907 - 939)

PUF

PUF: Pumilio-family RNA binding repeat (942 - 971)

PUF

PUF: Pumilio-family RNA binding repeat (990 - 1019)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1064 a.a.
蛋白主名 其他名称

pumilio homolog 2

pumilio-2

PUM2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Cross PUM2 Q8TB72 ORF Human immunodeficiency virus Q9Q2G4
Pull Down
22190034
Intra PUM2 Q8TB72 DAZ1 Homo sapiens Q9NQZ3
Anti Tag CoIP
12511597
Intra PUM2 Q8TB72 DAZ1 Homo sapiens Q9NQZ3
Y2H
12511597
Intra PUM2 Q8TB72 BOLL Homo sapiens Q8N9W6
Affinity Chrom
15806553
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Testis Seminoma

Seminoma Of Testis

Seminoma Testis

Testicular Seminoma Pure

Seminoma
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11462 PUM2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PUM2 VGNC VGNC:64437
Rattus norvegicus PUM2 RGD RGD:1311024
Mus musculus PUM2 MGD MGI:1931751
Macaca mulatta PUM2 VGNC VGNC:76480
Bos taurus PUM2 VGNC VGNC:33570
Canis familiaris PUM2 VGNC VGNC:45207
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