2. Gene
  3. SEC61G - SEC61 translocon subunit gamma Gene

SEC61G - SEC61 translocon subunit gamma Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SEC61 易位子亚基γ

种属: Homo sapiens

同用名: SSS1

基因 ID: 23480 | 基因类型: protein coding

关于 SEC61G

Cytogenetic location: 7p11.2 Genomic coordinates (GRCh38): 7:54,752,253-54,759,211 (from NCBI)

This gene has 7 transcripts (splice variants) and 250 orthologues. Ubiquitous expression in colon (RPKM 71.5), prostate (RPKM 56.4) and 25 other tissues.

功能概要

Sec61 复合体是内质网 (ER) 膜蛋白质易位装置的核心组成部分。 Sec61 复合物的寡聚体形成一个跨膜通道，蛋白质在此跨膜通道转运并整合到 ER 膜中。该复合物由三种膜蛋白组成——α、β 和γ。该基因编码γ-亚基蛋白。已经鉴定出编码相同蛋白质的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

SEC61G 基因产物(2)

mRNA Protein Name
NM_001012456.2 NP_001012474.1 protein transport protein Sec61 subunit gamma
NM_014302.4 NP_055117.1 protein transport protein Sec61 subunit gamma
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables ribosome binding IDA
IDA: 通过直接分析推断
32820719 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
22375059 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SEC61G 蛋白结构

SecE

SecE: SecE/Sec61-gamma subunits of protein translocation complex (12 - 66)

  • 0
  • 68 a.a.
蛋白主名 其他名称

protein transport protein Sec61 subunit gamma

SEC61 translocon gamma subunit

SEC61G 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SEC61G P60059 SFTPC Homo sapiens P11686
Y2H Array
25416956
Intra SEC61G P60059 SFTPC Homo sapiens P11686
Y2H Prey Pooling
25416956
Intra SEC61G P60059 LRRC25 Homo sapiens Q8N386
Y2H Prey Pooling
32296183
Intra SEC61G P60059 LRRC25 Homo sapiens Q8N386
Validated Y2H
32296183
Intra SEC61G P60059 LRRC25 Homo sapiens Q8N386
Y2H Array
32296183
Intra SEC61G P60059 LCN2 Homo sapiens P80188
Y2H Prey Pooling
32296183
Intra SEC61G P60059 LCN2 Homo sapiens P80188
Validated Y2H
32296183
Intra SEC61G P60059 LCN2 Homo sapiens P80188
Y2H Array
32296183
Intra SEC61G P60059 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra SEC61G P60059 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra SEC61G P60059 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra SEC61G P60059 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra SEC61G P60059 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra SEC61G P60059 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra SEC61G P60059 PEX12 Homo sapiens O00623
Y2H Array
32296183
Intra SEC61G P60059 PEX12 Homo sapiens O00623
Y2H Prey Pooling
32296183
Intra SEC61G P60059 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra SEC61G P60059 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra SEC61G P60059 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra SEC61G P60059 TMEM51 Homo sapiens Q9NW97
Validated Y2H
32296183
Intra SEC61G P60059 TMEM51 Homo sapiens Q9NW97
Y2H Array
32296183
Intra SEC61G P60059 TMEM51 Homo sapiens Q9NW97
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Childhood Ependymoma
Autosomal Dominant Severe Congenital Neutropenia

Severe Congenital Neutropenia Autosomal Dominant

Neutropenia, Congenital, Severe, Autosomal Dominant
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12623 SEC61G Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus SEC61G VGNC VGNC:49154
Mus musculus SEC61G MGD MGI:1202066
Rattus norvegicus SEC61G RGD RGD:1596170
Macaca mulatta SEC61G VGNC VGNC:108436
Canis familiaris SEC61G VGNC VGNC:49617
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