HAAO - 3-hydroxyanthranilate 3,4-dioxygenase Gene

中文名称：3-羟基邻氨基苯甲酸 3,4-双加氧酶

种属: Homo sapiens

同用名: HAO; 3-HAO; VCRL1; h3HAO

关于 HAAO

功能概要

3-羟基邻氨基苯甲酸 3,4-双加氧酶是一种单体胞质蛋白，属于含有非血红素亚铁的分子内双加氧酶家族。广泛分布于肝、肾等外周器官，在中枢神经系统中也有少量存在。 HAAO 催化从 3-羟基邻氨基苯甲酸合成喹啉酸 (QUIN) 。 QUIN 是一种兴奋性毒素，其毒性由其激活谷氨酸 N-甲基-D-天冬氨酸受体的能力介导。 QUIN 大脑水平升高可能参与神经系统和炎症性疾病的发病机制。 HAAO 已被建议在与 QUIN 组织水平改变相关的疾病中发挥作用。[RefSeq 提供，2008 年 7 月]

3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]