2. Gene
  3. SPIDR - scaffold protein involved in DNA repair Gene

SPIDR - scaffold protein involved in DNA repair Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：参与 DNA 修复的支架蛋白

种属: Homo sapiens

同用名: ODG9; KIAA0146

基因 ID: 23514 | 基因类型: protein coding

关于 SPIDR

Cytogenetic location: 8q11.21 Genomic coordinates (GRCh38): 8:47,260,878-47,736,306 (from NCBI)

This gene has 28 transcripts (splice variants), 173 orthologues and is associated with 2 phenotypes. Ubiquitous expression in lung (RPKM 8.1), thyroid (RPKM 7.9) and 25 other tissues.

功能概要

参与多个过程，包括细胞对喜树碱的反应；细胞对羟基脲的反应；和双链断裂修复的调节。位于核染色体和核质中。 [由基因组资源联盟提供，2022 年 4 月]

Involved in several processes, including cellular response to camptothecin; cellular response to hydroxyurea; and regulation of double-strand break repair. Located in nuclear chromosome and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SPIDR 基因产物(33)

mRNA Protein Name
NM_001080394.4 NP_001073863.1 DNA repair-scaffolding protein isoform 1
NM_001282916.1 NP_001269845.1 DNA repair-scaffolding protein isoform 2
NM_001282919.1 NP_001269848.1 DNA repair-scaffolding protein isoform 3
NM_001352931.1 NP_001339860.1 DNA repair-scaffolding protein isoform 4
NM_001352932.1 NP_001339861.1 DNA repair-scaffolding protein isoform 5
NM_001352933.1 NP_001339862.1 DNA repair-scaffolding protein isoform 6
NM_001352934.1 NP_001339863.1 DNA repair-scaffolding protein isoform 8
NM_001352935.1 NP_001339864.1 DNA repair-scaffolding protein isoform 9
NM_001352936.1 NP_001339865.1 DNA repair-scaffolding protein isoform 10
NM_001352937.1 NP_001339866.1 DNA repair-scaffolding protein isoform 11
NM_001352938.1 NP_001339867.1 DNA repair-scaffolding protein isoform 12
NM_001352939.1 NP_001339868.1 DNA repair-scaffolding protein isoform 12
NM_001352940.1 NP_001339869.1 DNA repair-scaffolding protein isoform 12
NM_001352941.1 NP_001339870.1 DNA repair-scaffolding protein isoform 13
NM_001352942.1 NP_001339871.1 DNA repair-scaffolding protein isoform 14
NM_001352943.1 NP_001339872.1 DNA repair-scaffolding protein isoform 15
NM_001352944.1 NP_001339873.1 DNA repair-scaffolding protein isoform 16
NM_001352945.1 NP_001339874.1 DNA repair-scaffolding protein isoform 17
NM_001352946.1 NP_001339875.1 DNA repair-scaffolding protein isoform 18
NM_001352947.1 NP_001339876.1 DNA repair-scaffolding protein isoform 18
NM_001352948.1 NP_001339877.1 DNA repair-scaffolding protein isoform 18
NM_001352949.1 NP_001339878.1 DNA repair-scaffolding protein isoform 19
NM_001352950.1 NP_001339879.1 DNA repair-scaffolding protein isoform 20
NM_001352951.1 NP_001339880.1 DNA repair-scaffolding protein isoform 21
NM_001352952.1 NP_001339881.1 DNA repair-scaffolding protein isoform 22
NM_001352953.1 NP_001339882.1 DNA repair-scaffolding protein isoform 22
NM_001352955.1 NP_001339884.1 DNA repair-scaffolding protein isoform 22
NM_001352956.1 NP_001339885.1 DNA repair-scaffolding protein isoform 22
NM_001352957.1 NP_001339886.1 DNA repair-scaffolding protein isoform 23
NM_001352958.1 NP_001339887.1 DNA repair-scaffolding protein isoform 24
NM_001352959.1 NP_001339888.1 DNA repair-scaffolding protein isoform 25
NM_001352960.1 NP_001339889.1 DNA repair-scaffolding protein isoform 26
NM_001352961.1 NP_001339890.1 DNA repair-scaffolding protein isoform 7
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
23509288 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
23509288 GOA
involved in cellular response to camptothecin IDA
IDA: 通过直接分析推断
23509288 GOA
involved in cellular response to hydroxyurea IDA
IDA: 通过直接分析推断
23509288 GOA
involved in cellular response to ionizing radiation IDA
IDA: 通过直接分析推断
23509288 GOA
involved in double-strand break repair via homologous recombination IMP
IMP: 通过突变表型推断
23509288 GOA
involved in positive regulation of double-strand break repair IMP
IMP: 通过突变表型推断
23509288 GOA
involved in positive regulation of protein-containing complex assembly IDA
IDA: 通过直接分析推断
23509288 GOA
involved in regulation of double-strand break repair via homologous recombination IDA
IDA: 通过直接分析推断
23754376 GOA
involved in regulation of establishment of protein localization to chromosome IDA
IDA: 通过直接分析推断
23509288 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nuclear chromosome IDA
IDA: 通过直接分析推断
23509288 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SPIDR 蛋白结构

DUF4502

DUF4502: Domain of unknown function (DUF4502) (11 - 369)

DUF4503

DUF4503: Domain of unknown function (DUF4503) (521 - 909)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 915 a.a.
蛋白主名 其他名称

DNA repair-scaffolding protein

scaffolding protein involved in DNA repair

SPIDR 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SPIDR Q14159 RAD51 Homo sapiens Q06609
Anti Bait CoIP
23509288
Intra SPIDR Q14159 SWSAP1 Homo sapiens Q6NVH7
Y3H
31665741
Intra SPIDR Q14159 ZSWIM7 Homo sapiens Q19AV6
Y3H
31665741
Intra SPIDR Q14159 BLM Homo sapiens P54132
Pull Down
23509288
Intra SPIDR Q14159 BLM Homo sapiens P54132
Anti Tag CoIP
23509288
Intra SPIDR Q14159 BLM Homo sapiens P54132
Anti Bait CoIP
23509288
Intra SPIDR Q14159 FIGNL1 Homo sapiens Q6PIW4
Y3H
31665741
Intra SPIDR Q14159 FIGNL1 Homo sapiens Q6PIW4
Y2H
31665741
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ovarian Dysgenesis 9

ODG9
46,Xx Sex Reversal 1

46,Xx Testicular Disorder Of Sex Development

46,Xx Gonadal Dysgenesis

SRXX1

46,Xx Gonadal Dysgenesis, Complete, Sry-Positive

46,Xx Testicular Dsd

Xx Male Syndrome

46,Xx Complete Gonadal Dysgenesis

46,Xx Pure Gonadal Dysgenesis

Follicular Stimulating Hormone-Resistant Ovaries

Hypergonadotropic Ovarian Dysgenesis

Ovotesticular Disorder Of Sex Development

46,Xx Sex Reversal, Sry-Positive

Xx Male, Sry-Positive

46xx Sex Reversal 1

46, Xx Gonadal Sex Reversal

Xx Sex Reversal

46,Xx Ovarian Dysgenesis

Fsh-Ro

Xx Female Gonadal Dysgenesis

Xx-Gd

46,Xx Ovotesticular Disorder Of Sex Development

46,Xx Ovotesticular Dsd

De La Chapelle Syndrome

Xx, Male Syndrome

46,Xx Gonadal Dysgenesis Complete Sry-Positive

46,Xx Sex Reversal Sry-Positive

46,Xx True Hermaphroditism Sry-Positive

Ovotesticular Dsd

Xx Male Sry-Positive

Ovotesticular Disorders Of Sex Development

46, Xx Testicular Disorders Of Sex Development

Resistant Ovary Syndrome

Dysgenetic Ovaries

Fsh-Ro - [Follicular Stimulating Hormone-Resistant Ovaries]

True Hermaphroditism

Ovotestis

True Hermaphrodite
Genetic Non-Acquired Premature Ovarian Failure
Uterine Hypoplasia
Gonadal Dysgenesis

Gonadal Dysgenesis Syndrome

Turner Syndrome
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13674 SPIDR Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SPIDR VGNC VGNC:46741
Mus musculus SPIDR MGD MGI:1924834
Bos taurus SPIDR VGNC VGNC:35216
Rattus norvegicus SPIDR RGD RGD:1566036
Felis catus SPIDR VGNC VGNC:81682
Macaca mulatta SPIDR VGNC VGNC:84118
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z