ARL2BP - ADP ribosylation factor like GTPase 2 binding protein Gene

中文名称：ADP 核糖基化因子样 GTPase 2 结合蛋白

种属: Homo sapiens

同用名: BART; RP66; BART1

基因 ID: 23568 | 基因类型: protein coding

关于 ARL2BP

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:57,245,259-57,253,635 (from NCBI)

This gene has 4 transcripts (splice variants), 228 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 36.7), fat (RPKM 27.6) and 25 other tissues.

功能概要

ADP-核糖基化因子 (ARF) 样蛋白 (ARL) 包含 Ras 相关 GTP 酶的 ARF 家族中功能不同的一组。由该基因编码的蛋白质以高亲和力与 ARL2.GTP 结合，但不与 ARL2.GDP、活化的 ARF 或 RHO 蛋白质相互作用。在激活 ARL2 后，这种蛋白质或 ARL2 缺乏可检测的膜结合，这表明其作用不同于 ARF 的作用。由于该蛋白与 ARL2.GTP 相互作用但缺乏 ARL2 GTP 酶激活蛋白活性，因此被认为是第一个鉴定出的 ARL2 特异性效应物。[RefSeq 提供，2008 年 7 月]

ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity. [provided by RefSeq, Jul 2008]

ARL2BP 基因产物(1)

mRNA	Protein	Name
NM_012106.4	NP_036238.1	ADP-ribosylation factor-like protein 2-binding protein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	11847227	GOA
enables transcription coactivator activity	IMP IMP: 通过突变表型推断	18234692	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in maintenance of protein location in nucleus	IMP IMP: 通过突变表型推断	18234692	GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein	IMP IMP: 通过突变表型推断	18234692	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in centrosome	IDA IDA: 通过直接分析推断	16525022	GOA
located in midbody	IDA IDA: 通过直接分析推断	16525022	GOA
located in mitochondrial intermembrane space	IDA IDA: 通过直接分析推断	11809823	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARL2BP 蛋白结构

ARL2_Bind_BART

0
100
163 a.a.

蛋白主名

其他名称

ADP-ribosylation factor-like protein 2-binding protein

ADP-ribosylation factor like 2 binding protein

ARL2BP 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ARL2BP	Q9Y2Y0	CFAP20	Homo sapiens	Q9Y6A4	Anti Tag CoIP	33961781
种属内	ARL2BP	Q9Y2Y0	CFAP20	Homo sapiens	Q9Y6A4	Validated Y2H	32296183
种属内	ARL2BP	Q9Y2Y0	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
种属内	ARL2BP	Q9Y2Y0	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
种属内	ARL2BP	Q9Y2Y0	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
种属内	ARL2BP	Q9Y2Y0	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
种属内	ARL2BP	Q9Y2Y0	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
种属内	ARL2BP	Q9Y2Y0	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
种属内	ARL2BP	Q9Y2Y0	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
种属内	ARL2BP	Q9Y2Y0	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
种属内	ARL2BP	Q9Y2Y0	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
种属内	ARL2BP	Q9Y2Y0	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
种属内	ARL2BP	Q9Y2Y0	GSN	Homo sapiens	P06396	Validated Y2H	32814053
种属内	ARL2BP	Q9Y2Y0	GSN	Homo sapiens	P06396	Y2H Array	32814053
种属内	ARL2BP	Q9Y2Y0	ARL3	Homo sapiens	P36405	Y2H Prey Pooling	32296183
种属内	ARL2BP	Q9Y2Y0	ARL3	Homo sapiens	P36405	Y2H Array	32296183
种属内	ARL2BP	Q9Y2Y0	ARL3	Homo sapiens	P36405	Anti Tag CoIP	33961781
种属内	ARL2BP	Q9Y2Y0	ARL2	Homo sapiens	P36404	Validated Y2H	27107012
种属内	ARL2BP	Q9Y2Y0	ARL2	Homo sapiens	P36404	Y2H Array	32296183
种属内	ARL2BP	Q9Y2Y0	ARL2	Homo sapiens	P36404	Anti Tag CoIP	33961781
种属内	ARL2BP	Q9Y2Y0	ARL2	Homo sapiens	P36404	Pull Down	19368893
种属内	ARL2BP	Q9Y2Y0	ARL2	Homo sapiens	P36404	Y2H Array	21988832
种属内	ARL2BP	Q9Y2Y0	ARL2	Homo sapiens	P36404	GMS	19368893
种属内	ARL2BP	Q9Y2Y0	ARL2	Homo sapiens	P36404	X-Ray Diffraction	19368893
种属内	ARL2BP	Q9Y2Y0	ARL2	Homo sapiens	P36404	Y2H Prey Pooling	25416956
种属内	ARL2BP	Q9Y2Y0	ARL2	Homo sapiens	P36404	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ARL2BP 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71660	ARL2BP Protein, Human (GST)	Q9Y2Y0-1 (M1-H163)	≥95%
HY-P76156	ARL2BP Protein, Human (His)	Q9Y2Y0-1 (M1-H163)	≥95%

关联疾病

疾病名称

别名

Retinitis Pigmentosa 82 With Or Without Situs Inversus

Retinitis Pigmentosa With Or Without Situs Inversus	RP82
Retinitis Pigmentosa, With/Without Situs Inversus

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Retinitis Pigmentosa 66

RP66	Retinitis Pigmentosa, Type 66

Ciliary Dyskinesia, Primary, 43

CILD43	Primary Ciliary Dyskinesia 43
Ciliary Dyskinesia, Primary, 43, With Or Without Situs Inversus	Primary Ciliary Dyskinesia 43 With Or Without Situs Inversus
Ciliary Dyskinesia, Primary, 43 With Or Without Situs Inversus

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Retinitis Pigmentosa 74

RP74	Retinitis Pigmentosa, Type 74

Oral Hairy Leukoplakia

Hairy Leukoplakia	Leukoplakia, Hairy
Hairy Leucoplakia

Situs Inversus

Situs Inversus Viscerum	Laterality Sequence
Complete Transposition	Siv

Nasopharyngeal Carcinoma

Malignant Neoplasm Of Nasopharynx	Npc
Nasopharyngeal Cancer	Nasopharyngeal Carcinoma 1
Nasopharynx Carcinoma	Nasopharyngeal Neoplasms
Npca	Carcinoma Of Nasopharynx
Malignant Nasopharyngeal Tumor	Nasopharynx Cancer
Squamous Cell Carcinoma Of The Nasopharynx	Nasopharyngeal Neoplasm
Cancer Of Nasopharynx

Keratinizing Squamous Cell Carcinoma

Squamous Cell Carcinoma, Keratinizing

Keratinizing Epidermoid Carcinoma

Pfeiffer Syndrome

Infectious Mononucleosis	Acs5
Craniofacial-Skeletal-Dermatologic Dysplasia	Acs V
Noack Syndrome	Gammaherpesviral Mononucleosis
Acrocephalosyndactyly Type 5	Pfeiffer Syndrome Type 3
Acrocephalosyndactyly, Type V	Glandular Fever
Pfeiffer Type Acrocephalosyndactyly	Pfeiffer Syndrome Type 2
Acrocephalosyndactylia Type V	Filatov'S Disease
Monocytic Angina	Mononucleosis
Pfeiffer'S Disease	Acsv
Acrocephalosyndactyly, Type 5	Craniofacial-Skeletal-Dermatologic Syndrome
Pfeiffer Syndrome Type 1	Classic Pfeiffer Syndrome
PS	Pfeiffer Syndrome Variant
Dysplasia, Craniofacial-Skeletal-Dermatologic	Pfeiffer
Kissing Disease	Infectious Adenitis
Pfeiffer Disease

Bare Lymphocyte Syndrome, Type I

Hla Class I Deficiency	Mhc Class I Deficiency
Bls, Type I	Bare Lymphocyte Syndrome Type I
Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency	Blsi
Mhc Class 1 Deficiency	Major Histocompatibility Complex Class 1 Deficiency
Bare Lymphocyte Syndrome 1	BLS1
Bls I	Bls Type I
Bl-1	Bare Lymphocyte Syndrome Type 1
Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1	Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens
Bls - [Bare Lymphocyte Syndrome] Nos

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00986	ARL2BP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	ARL2BP	VGNC	VGNC:104681
Mus musculus	ARL2BP	MGD	MGI:1349429
Bos taurus	ARL2BP	VGNC	VGNC:26142
Rattus norvegicus	ARL2BP	RGD	RGD:1561471
Canis familiaris	ARL2BP	VGNC	VGNC:38110
Others	ARL2BP	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ARL2BP - ADP ribosylation factor like GTPase 2 binding protein Gene

关于 ARL2BP

功能概要

ARL2BP 基因产物(1)

ARL2BP 蛋白结构

ARL2BP 蛋白互作信息

重组 ARL2BP 蛋白

关联疾病

直系同源

热门区域

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ARL2BP - ADP ribosylation factor like GTPase 2 binding protein Gene

关于 ARL2BP

功能概要

ARL2BP 基因产物(1)

ARL2BP 蛋白结构

ARL2BP 蛋白互作信息

重组 ARL2BP 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z