2. Gene
  3. Phgdh - 3-phosphoglycerate dehydrogenase Gene

Phgdh - 3-phosphoglycerate dehydrogenase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：3-磷酸甘油酸脱氢酶

种属: Mus musculus

同用名: A10; PGD; PGAD; PGDH; SERA; 3PGDH; 3-PGDH; 4930479N23

基因 ID: 236539 | 基因类型: protein coding

关于 Phgdh

Chromosome 3: 98,220,486-98,247,306 reverse strand.GRCm39:CM000996.3

This gene has 4 transcripts (splice variants), 217 orthologues, 3 paralogues and is associated with 56 phenotypes. Broad expression in placenta adult (RPKM 138.), genital fat pad adult (RPKM 127.9) and 25 other tissues.

功能概要

预计该基因编码的蛋白可启动磷酸甘油酸脱氢酶活性。作用于多个过程的上游或内部，包括 G1 到 G0 的过渡；细胞氨基酸代谢过程；和神经系统发育。位于髓鞘内。以多种结构表达，包括消化系统；脑;泌尿生殖系统；外皮系统；和感觉器官。该基因的人类直系同源物与 Neu-Laxova 综合征 1 有关； PHGDH 缺乏症；和氨基酸代谢紊乱。与人 PHGDH（磷酸甘油酸脱氢酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable phosphoglycerate dehydrogenase activity. Acts upstream of or within several processes, including G1 to G0 transition; cellular amino acid metabolic process; and nervous system development. Located in myelin sheath. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 1; PHGDH deficiency; and amino acid metabolic disorder. Orthologous to human PHGDH (phosphoglycerate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

Phgdh 基因产物(1)

mRNA Protein Name
NM_016966.3 NP_058662.2 D-3-phosphoglycerate dehydrogenase
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within G1 to G0 transition IMP
IMP: 通过突变表型推断
19114063 MGI
acts upstream of or within L-serine metabolic process IMP
IMP: 通过突变表型推断
19114063 MGI
acts upstream of or within gamma-aminobutyric acid metabolic process IMP
IMP: 通过突变表型推断
19114063 MGI
acts upstream of or within glial cell development IMP
IMP: 通过突变表型推断
19114063 MGI
acts upstream of or within glutamine metabolic process IMP
IMP: 通过突变表型推断
19114063 MGI
acts upstream of or within glycine metabolic process IMP
IMP: 通过突变表型推断
19114063 MGI
acts upstream of or within neural tube development IMP
IMP: 通过突变表型推断
19114063 MGI
acts upstream of or within neurogenesis IMP
IMP: 通过突变表型推断
19114063 MGI
acts upstream of or within neuron projection development IMP
IMP: 通过突变表型推断
19114063 MGI
acts upstream of or within regulation of gene expression IMP
IMP: 通过突变表型推断
19114063 MGI
acts upstream of or within spinal cord development IMP
IMP: 通过突变表型推断
19114063 MGI
acts upstream of or within taurine metabolic process IMP
IMP: 通过突变表型推断
19114063 MGI
acts upstream of or within threonine metabolic process IMP
IMP: 通过突变表型推断
19114063 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Phgdh 蛋白结构

PGDH_4

PGDH_4: cd12173 (7 - 309)

PGDH_inter

PGDH_inter: cl44735 (329 - 406)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 533 a.a.
蛋白主名 其他名称

D-3-phosphoglycerate dehydrogenase

3-phosphoglycerate dehyrogenase

相关产品

Pre-clinical Phase
生物活性分子 (17)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101966 NCT-503 99.85% 否
HY-100012 CBR-5884 99.02% 否
HY-141412 D-(-)-3-Phosphoglyceric acid disodium Inhibitor ≥98.0% 否
HY-117240 NCT-502 99.72% 否
HY-123269 PKUMDL-WQ-2101 Inhibitor 99.94% 否
HY-126253 BI-4916 98.55% 否
HY-126254 BI-4924 99.55% 否
HY-148570 PHGDH-IN-3 Inhibitor 98.99% 否
HY-121733 PHGDH-inactive 99.93% 否
HY-123418 PKUMDL-WQ-2201 Inhibitor 98.72% 否
HY-RS10433 Phgdh Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-145860 PHGDH-IN-2 / 否
HY-RS10432 PHGDH Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10434 Phgdh Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-125273 DNS-pE / 否
HY-160252 PHGDH-IN-4 Inhibitor / 否
HY-161456 PHGDH-IN-5 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Phgdh NCBI NCBI:26227
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