2. Gene
  3. TMEFF2 - transmembrane protein with EGF like and two follistatin like domains 2 Gene

TMEFF2 - transmembrane protein with EGF like and two follistatin like domains 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：具有 EGF 样结构域和两个卵泡抑素样结构域的跨膜蛋白 2

种属: Homo sapiens

同用名: TR; HPP1; TPEF; TR-2; TENB2; CT120.2

基因 ID: 23671 | 基因类型: protein coding

关于 TMEFF2

Cytogenetic location: 2q32.3 Genomic coordinates (GRCh38): 2:191,949,046-192,194,933 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues and 27 paralogues. Biased expression in prostate (RPKM 5.9), brain (RPKM 4.8) and 3 other tissues.

功能概要

该基因编码跨膜蛋白 tomoregulin 家族的成员。这种蛋白质已被证明既可以作为致癌基因又可以作为肿瘤抑制因子，这取决于细胞环境，并且可以调节前列腺癌细胞的侵袭。已经鉴定出这种蛋白质的多种可溶性形式，它们是由可变剪接变体和胞外域脱落引起的。此外，已发现该基因在多种癌症类型中高度甲基化。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 2 月]

This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate Cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple Cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

TMEFF2 基因产物(3)

mRNA Protein Name
NM_001305134.2 NP_001292063.1 tomoregulin-2 isoform 2 precursor
NM_001305145.1 NP_001292074.1 tomoregulin-2 isoform 3 precursor
NM_016192.4 NP_057276.2 tomoregulin-2 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
26402097 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within negative regulation of cell migration IDA
IDA: 通过直接分析推断
24632071 GOA
acts upstream of or within negative regulation of integrin biosynthetic process IMP
IMP: 通过突变表型推断
24632071 GOA
acts upstream of or within negative regulation of stress fiber assembly IDA
IDA: 通过直接分析推断
24632071 GOA
acts upstream of or within wound healing, spreading of cells IDA
IDA: 通过直接分析推断
24632071 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TMEFF2 蛋白结构

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (95 - 135)

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (186 - 227)

hEGF

hEGF: Human growth factor-like EGF (288 - 300)

  • 0
  • 100
  • 200
  • 300
  • 374 a.a.
蛋白主名 其他名称

tomoregulin-2

cancer/testis antigen family 120, member 2

TMEFF2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TMEFF2 Q9UIK5 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
种属内
TMEFF2 Q9UIK5 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
种属内
TMEFF2 Q9UIK5 TRHR Homo sapiens P34981
Y2H Prey Pooling
32296183
种属内
TMEFF2 Q9UIK5 TRHR Homo sapiens P34981
Y2H Array
32296183
种属内
TMEFF2 Q9UIK5 P05067-PRO_0000000090 Homo sapiens P05067-PRO_0000000090
Pull Down
26402097
种属内
TMEFF2 Q9UIK5 P05067-PRO_0000000090 Homo sapiens P05067-PRO_0000000090
Anti Bait CoIP
26402097
种属内
TMEFF2 Q9UIK5 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
种属内
TMEFF2 Q9UIK5 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
种属内
TMEFF2 Q9UIK5 UBIAD1 Homo sapiens Q9Y5Z9
Validated Y2H
32296183
种属内
TMEFF2 Q9UIK5 HSF2BP Homo sapiens O75031
Y2H Array
32296183
种属内
TMEFF2 Q9UIK5 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TMEFF2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700470 TMEFF2/Tomoregulin-2 Protein, Human (HEK293, His) Q9UIK5 (F41-V320) ≥95%

TMEFF2 抗体

目录号 产品名 应用 反应物种
HY-P82290 Tomoregulin 2 Antibody (YA2035) WB, IHC-P, ICC/IF, FC Human

关联疾病

疾病名称 别名
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14642 TMEFF2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990692 Ciduvectamig Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TMEFF2 RGD RGD:1308839
Mus musculus TMEFF2 MGD MGI:1861735
Canis familiaris TMEFF2 VGNC VGNC:47442
Bos taurus TMEFF2 VGNC VGNC:35940
Macaca mulatta TMEFF2 VGNC VGNC:78569
Felis catus TMEFF2 VGNC VGNC:66252
Others TMEFF2 NCBI
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